EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer

doi:10.1039/c8nr05803b

	EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer
	Li, Yuan 1,2,3,4; Du, Yang3,5 ; Liang, Xiaolong 2,6; Sun, Ting 1,2,3; Xue, Huadan 1,2; Tian, Jie 3,5; Jin, Zhengyu 1,2
发表期刊	NANOSCALE
ISSN	2040-3364
	2018-09-21
卷号	10 期号:35 页码:16738-16749
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Jin, Zhengyu(zhengyu_jin1960@126.com)
摘要	Epidermal growth factor receptor (EGFR) is a major target for the treatment of colorectal cancers (CRCs), and programmed death ligand-1(PD-L1) is an attractive target for CRC immunotherapy. Herein, we report the synthesis of porphyrin-containing liposomal nanohybrid cerasomes decorated with cetuximab, an anti-EGFR antibody, and conjugated with IRDye800CW and MRI contrast DOTA-Gd, to enable in vivo tumor detection and photodynamic therapy (PDT). Moreover, PD-L1 was added for adjuvant therapy. The antitumor efficacy of PDT combined with PD-L1 immunotherapy was assessed. EGFR-targeted nanoparticles showed the targeted imaging of tumors. EGFR-targeted PDT combined with PD-L1 immunotherapy was more effective against tumor growth than simultaneous albeit nontargeted nanoparticle delivery with laser irradiation plus PD-L1 immunotherapy. Thus, EGFR-targeted nanoparticles exhibited significant potential toward dual-modality imaging-guided precise PDT, combined with immunotherapy.
DOI	10.1039/c8nr05803b
关键词[WOS]	TUMOR-INFILTRATING LYMPHOCYTES ; CELL LUNG-CANCER ; PHOTODYNAMIC THERAPY ; BREAST-CANCER ; NANOPARTICLES ; COMBINATION ; CHEMOTHERAPY ; NIVOLUMAB ; EFFICACY
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81571810] ; National Natural Science Foundation of China[81771846] ; Chinese Academy of Sciences[XDB02060010] ; International Innovation Team of CAS[20140491524] ; Beijing Municipal Science & Technology Commission[Z161100002616022] ; Peking University Third Hospital[BYSY2015023] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81571810] ; National Natural Science Foundation of China[81771846] ; Chinese Academy of Sciences[XDB02060010] ; International Innovation Team of CAS[20140491524] ; Beijing Municipal Science & Technology Commission[Z161100002616022] ; Peking University Third Hospital[BYSY2015023]
项目资助者	National Natural Science Foundation of China ; Chinese Academy of Sciences ; International Innovation Team of CAS ; Beijing Municipal Science & Technology Commission ; Peking University Third Hospital
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:000448419900041
出版者	ROYAL SOC CHEMISTRY
引用统计	被引频次：58[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/22579
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Jin, Zhengyu
作者单位	1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, 1 Shuaifuyuan, Beijing 100730, Peoples R China 2.Peking Union Med Coll, 1 Shuaifuyuan, Beijing 100730, Peoples R China 3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, 95 ZhongGuanCun East Rd, Beijing 100190, Peoples R China 4.Peking Univ, Dept Radiol, Hosp 3, Beijing 100191, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 6.Peking Univ, Dept Ultrasound, Hosp 3, Beijing 100191, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Li, Yuan,Du, Yang,Liang, Xiaolong,et al. EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer[J]. NANOSCALE,2018,10(35):16738-16749.
APA	Li, Yuan.,Du, Yang.,Liang, Xiaolong.,Sun, Ting.,Xue, Huadan.,...&Jin, Zhengyu.(2018).EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer.NANOSCALE,10(35),16738-16749.
MLA	Li, Yuan,et al."EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer".NANOSCALE 10.35(2018):16738-16749.