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PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model
Li Yuan; Du Yang; Sun Ting; Xue Huadan; Jin Zhengyu; Tian Jie
发表期刊BMC Cancer
2018-06-19
卷号18期号:1页码:669
摘要

Background: Blockade of PD-1 receptor may provide proof of concepts for the activity of an immune-modulation approach for the treatment of breast cancer (BC). Zoledronic acid (ZA) has been proven to inhibit angiogenesis, invasion, and adhesion of tumor cells. The aim of this study was to investigate the potential of monoclonal antibody againstT cell checkpoint PD-1 in combination with chemotherapeutic drug ZA in BC mouse model.

Methods: The4T1-fLuc mouse BC model was used in this study. The anti-tumor efficacy of anti-PD-1 antibody alone or in combination with ZA was monitored by measuring bioluminescence imaging (BLI) and tumor volume. At the end of study, the flow cytometry was used to determine the immune cell population in tumors after different treatment.

关键词Pd-1, Zoledronic Acid, Breast Cancer, Therapy, Checkpoint Inhibitior
语种英语
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/23180
专题中国科学院分子影像重点实验室
通讯作者Jin Zhengyu; Tian Jie
推荐引用方式
GB/T 7714
Li Yuan,Du Yang,Sun Ting,et al. PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model[J]. BMC Cancer,2018,18(1):669.
APA Li Yuan,Du Yang,Sun Ting,Xue Huadan,Jin Zhengyu,&Tian Jie.(2018).PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model.BMC Cancer,18(1),669.
MLA Li Yuan,et al."PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model".BMC Cancer 18.1(2018):669.
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