PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model

doi:10.1186/s12885-018-4412-8

	PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model
	Li, Yuan 1,2; Du, Yang3 ; Sun, Ting 1,2; Xue, Huadan 1,2; Jin, Zhengyu 1,2; Tian, Jie 3
发表期刊	BMC CANCER
ISSN	1471-2407
	2018-06-19
卷号	18 页码:7
通讯作者	Jin, Zhengyu(jin_zhengyu@163.com) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要	Background: Blockade of PD-1 receptor may provide proof of concepts for the activity of an immune-modulation approach for the treatment of breast cancer (BC). Zoledronic acid (ZA) has been proven to inhibit angiogenesis, invasion, and adhesion of tumor cells. The aim of this study was to investigate the potential of monoclonal antibody against T cell checkpoint PD-1 in combination with chemotherapeutic drug ZA in BC mouse model. Methods: The 4 T1-fLuc mouse BC model was used in this study. The anti-tumor efficacy of anti-PD-1 antibody alone or in combination with ZA was monitored by measuring bioluminescence imaging (BLI) and tumor volume. At the end of study, the flow cytometry was used to determine the immune cell population in tumors after different treatment. Results: The results showed that mice treated with the combination therapy of anti-PD-1 antibody plus ZA exhibited better antitumor response compared to untreated controls or single therapy with no obvious toxicity. Conclusion: Our study provides preclinical evidence for the enhanced BC treatment benefit through targeting co-signal molecules by combining anti-PD-1 antibody plus ZA treatment.
关键词	PD-1 Zoledronic acid Breast cancer Therapy Checkpoint inhibitior
DOI	10.1186/s12885-018-4412-8
关键词[WOS]	CHECKPOINT INHIBITORS ; PHASE-3 TRIAL ; OPEN-LABEL ; METASTASES ; ANTIBODY ; THERAPY ; LIGAND ; SAFETY
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81171390] ; Key Projects in the National Science & Technology Pillar Program[2012BAI23B06] ; Strategic Priority Research Program from Chinese Academy of Sciences[XDB02060010] ; International Innovation Team of CAS[20140491524] ; Beijing Municipal Science & Technology Commission[Z161100002616022] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81171390] ; Key Projects in the National Science & Technology Pillar Program[2012BAI23B06] ; Strategic Priority Research Program from Chinese Academy of Sciences[XDB02060010] ; International Innovation Team of CAS[20140491524] ; Beijing Municipal Science & Technology Commission[Z161100002616022]
项目资助者	National Natural Science Foundation of China ; Key Projects in the National Science & Technology Pillar Program ; Strategic Priority Research Program from Chinese Academy of Sciences ; International Innovation Team of CAS ; Beijing Municipal Science & Technology Commission
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000435892200004
出版者	BIOMED CENTRAL LTD
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/23180
专题	中国科学院分子影像重点实验室
通讯作者	Jin, Zhengyu; Tian, Jie
作者单位	1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, 1 Shuaifuyuan, Beijing 100730, Peoples R China 2.Peking Union Med Coll, 1 Shuaifuyuan, Beijing 100730, Peoples R China 3.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging CAS, 95 ZhongGuanCun East Rd, Beijing 100190, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Li, Yuan,Du, Yang,Sun, Ting,et al. PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model[J]. BMC CANCER,2018,18:7.
APA	Li, Yuan,Du, Yang,Sun, Ting,Xue, Huadan,Jin, Zhengyu,&Tian, Jie.(2018).PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model.BMC CANCER,18,7.
MLA	Li, Yuan,et al."PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model".BMC CANCER 18(2018):7.

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