CASIA OpenIR  > 中国科学院分子影像重点实验室
PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model
Li Yuan; Du Yang; Sun Ting; Xue Huadan; Jin Zhengyu; Tian Jie
Source PublicationBMC Cancer
2018-06-19
Volume18Issue:1Pages:669
Abstract

Background: Blockade of PD-1 receptor may provide proof of concepts for the activity of an immune-modulation approach for the treatment of breast cancer (BC). Zoledronic acid (ZA) has been proven to inhibit angiogenesis, invasion, and adhesion of tumor cells. The aim of this study was to investigate the potential of monoclonal antibody againstT cell checkpoint PD-1 in combination with chemotherapeutic drug ZA in BC mouse model.

Methods: The4T1-fLuc mouse BC model was used in this study. The anti-tumor efficacy of anti-PD-1 antibody alone or in combination with ZA was monitored by measuring bioluminescence imaging (BLI) and tumor volume. At the end of study, the flow cytometry was used to determine the immune cell population in tumors after different treatment.

KeywordPd-1, Zoledronic Acid, Breast Cancer, Therapy, Checkpoint Inhibitior
Language英语
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/23180
Collection中国科学院分子影像重点实验室
Corresponding AuthorJin Zhengyu; Tian Jie
Recommended Citation
GB/T 7714
Li Yuan,Du Yang,Sun Ting,et al. PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model[J]. BMC Cancer,2018,18(1):669.
APA Li Yuan,Du Yang,Sun Ting,Xue Huadan,Jin Zhengyu,&Tian Jie.(2018).PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model.BMC Cancer,18(1),669.
MLA Li Yuan,et al."PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model".BMC Cancer 18.1(2018):669.
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