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Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity
Liu Shu1,2; Li Ang1,2; Liu Yong1,2,3; Yan Hao4,5; Wang Meng1,2; Sun Yuqing1,2; Fan Lingzhong1,2; Song Ming1,2; Xu Kaibin1,2; Chen Jun6; Chen Yunchun7; Wang Huaning7; Guo Hua8; Wan Ping8; Lv Luxian9,10; Yang Yongfeng9,10; Li Peng4,5; Lu Lin4,5; Yan Jun4,5; Wang Huiling6,11; Zhang Hongxing9,10,12; Wu Huawang13; Ning Yuping13; Zhang Dai4,5,14; Jiang Tianzi1,2,3,15,16; Liu Bing1,2,3
发表期刊The British Journal of Psychiatry
2019-06-06
期号2019页码:1-8
摘要

Background
Schizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure and function are a plausible neurobiological characterisation of schizophrenia. However, the polygenic effects of schizophrenia on these imaging endophenotypes have not yet been fully elucidated.
Aims
To investigate the effects of polygenic risk for schizophrenia on the brain grey matter volume and functional connectivity, which are disrupted in schizophrenia.
Method
Genomic and neuroimaging data from a large sample of Han Chinese patients with schizophrenia (N = 509) and healthy controls (N = 502) were included in this study. We examined grey matter volume and functional connectivity via structural and functional magnetic resonance imaging, respectively. Using the data from a recent meta-analysis of a genome-wide association study that comprised a large number of Chinese people, we calculated a polygenic risk score (PGRS) for each participant.

Results
The imaging genetic analysis revealed that the individual PGRS showed a significantly negative correlation with the hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity, both of which were lower in the people with schizophrenia than in the controls. We also found that the observed neuroimaging measures showed weak but similar changes in unaffected first-degree relatives of patients with schizophrenia.
Conclusions
These findings suggested that genetically influenced brain grey matter volume and functional connectivity may provide important clues for understanding the pathological mechanisms of schizophrenia and for the early diagnosis of schizophrenia

关键词Schizophrenia Polygenic Risk Score Hippocampus Rey Matter Volume Functional Connectivity
DOI10.1192/bjp.2019.127
收录类别SCI
语种英语
七大方向——子方向分类脑网络分析
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/23894
专题脑图谱与类脑智能实验室_脑网络组研究
通讯作者Liu Bing
作者单位1.Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences
2.University of Chinese Academy of Sciences
3.CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation
4.Peking University Sixth Hospital /Institute of Mental Health
5.Key Laboratory of Mental Health, Ministry of Health (Peking University)
6.Department of Radiology, Renmin Hospital of Wuhan University
7.Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University
8.Zhumadian Psychiatric Hospital
9.Department of Psychiatry, Henan Mental Hospital ,The Second Affiliated Hospital of Xinxiang Medical University
10.Henan Key Lab of Biological Psychiatry, Xinxiang Medical University
11.Department of Psychiatry, Renmin Hospital of Wuhan University
12.Department of Psychology, Xinxiang Medical University
13.Guangzhou Brain Hospital, The Affiliated Brain Hospital of Guangzhou Medical University
14.Center for Life Sciences/ PKU-IDG/McGovern Institute for Brain Research, Peking University
15.Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China
16.Queensland Brain Institute, University of Queensland
第一作者单位模式识别国家重点实验室
通讯作者单位模式识别国家重点实验室
推荐引用方式
GB/T 7714
Liu Shu,Li Ang,Liu Yong,等. Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity[J]. The British Journal of Psychiatry,2019(2019):1-8.
APA Liu Shu.,Li Ang.,Liu Yong.,Yan Hao.,Wang Meng.,...&Liu Bing.(2019).Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity.The British Journal of Psychiatry(2019),1-8.
MLA Liu Shu,et al."Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity".The British Journal of Psychiatry .2019(2019):1-8.
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