MIR137 polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex | |
Liu Shu; Li Ang; Liu Yong; Li Jin; Wang Meng; Sun Yuqing; Qin Wen; Yu Chunshui; Jiang Tianzi; Liu Bing | |
发表期刊 | Psychological Medicine |
2019 | |
期号 | 无页码:无 |
摘要 | Background. Genome-wide association studies (GWAS) have consistently revealed that a variant of microRNA 137 (MIR137) shows a quite significant association with schizophrenia. Identifying the network of genes regulated by MIR137 could provide insights into the biological processes underlying schizophrenia. In addition, DLPFC functional connectivity, a robust correlate of MIR137, may provide plausible endophenotypes. However, the regulatory role of the MIR137 gene network in the disrupted functional connectivity remains unclear. Here, we tested the effects of the MIR137 regulated genes on the risk for schizophrenia and DLPFC functional connectivity. |
关键词 | Dorsolateral Prefrontal Cortex Functional Connectivity Microrna-137 Polygenic Risk Score Schizophrenia |
收录类别 | SCI |
语种 | 英语 |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/23895 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
通讯作者 | Liu Bing |
作者单位 | 1.Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences 2.University of Chinese Academy of Sciences 3.CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences 4.Department of Radiology, Tianjin Medical University General Hospital 5.Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China 6.Queensland Brain Intute, University of Queensland |
推荐引用方式 GB/T 7714 | Liu Shu,Li Ang,Liu Yong,et al. MIR137 polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex[J]. Psychological Medicine,2019(无):无. |
APA | Liu Shu.,Li Ang.,Liu Yong.,Li Jin.,Wang Meng.,...&Liu Bing.(2019).MIR137 polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex.Psychological Medicine(无),无. |
MLA | Liu Shu,et al."MIR137 polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex".Psychological Medicine .无(2019):无. |
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