Cortical thinning and flattening in schizophrenia and their unaffected parents
Yan, Jing1; Cui, Yue2,3; Li, Qianqian1; Tian, Lin4,5; Liu, Bing2,3; Jiang, Tianzi2,3; Zhang, Dai1,6,7; Yan, Hao1
Corresponding AuthorZhang, Dai( ; Yan, Hao(
AbstractBackground: Schizophrenia is a neurodevelopmental disorder with high heritability. Widespread cortical thinning has been identified in schizophrenia, suggesting that it is a result of cortical development deficit. However, the findings of other cortical morphological indexes of patients are inconsistent, and the research on their relationship with genetic risk factors for schizophrenia is rare. Methods: In order to investigate cortical morphology deficits and their disease-related genetic liability in schizophrenia, we analyzed a sample of 33 patients with schizophrenia, 60 biological parents of the patients, as well as 30 young controls for patients and 28 elderly controls for parents with age, sex and education level being well-matched. We calculated vertex-wise measurements of cortical thickness, surface area, local gyrification index, sulcal depth, and their correlation with the clinical and cognitive characteristics. Results: Widespread cortical thinning of the fronto-temporo-parietal region, sulcal flattening of the insula and gyrification reduction of the frontal cortex were observed in schizophrenia patients. Conjunction analysis revealed that patients with schizophrenia and their parents shared significant cortical thinning of bilateral prefrontal and insula, left lateral occipital and fusiform regions (Monte Carlo correction, P<0.05), as well as a trend-level sulcal depth reduction mainly in bilateral insula and occipital cortex. We observed comprehensive cognitive deficits in patients and similar impairment in the speed of processing of their unaffected parents Significant associations between lower processing speed and thinning of the frontal cortex and flattening of the parahippocampal gyms were found in patients and their parents, respectively. However, no significant correlation between abnormal measurements of cortical morphology and clinical characteristics was found. Conclusion: The results suggest that cortical morphology may be susceptible to a genetic risk of schizophrenia and could underlie the cognitive dysfunction in patients and their unaffected relatives. The abnormalities shared with unaffected parents allow us to better understand the disease-specific genetic effect on cortical development.
Keywordschizophrenia first-degree relatives cortical thickness sulcus depth insula speed of processing
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81370032] ; National Natural Science Foundation of China[81771443] ; National Natural Science Foundation of China[91432304] ; National Natural Science Foundation of China[31771076]
Funding OrganizationNational Natural Science Foundation of China
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000464704700001
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Document Type期刊论文
Corresponding AuthorZhang, Dai; Yan, Hao
Affiliation1.Peking Univ, Natl Clin Res Ctr Mental Disorders, NHC Key Lab Mental Hlth, Inst Mental Hlth,Hosp 6, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Nanjing Med Univ, Dept Psychiat, Wuxi Mental Hlth Ctr, Wuxi 214151, Peoples R China
5.Nanjing Med Univ, Wuxi Tongren Int Rehabil Hosp, Wuxi Mental Hlth Ctr, Wuxi 214151, Peoples R China
6.Peking Univ, Peking Tsinghua Joint Ctr Life Sci, Beijing 100871, Peoples R China
7.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Yan, Jing,Cui, Yue,Li, Qianqian,et al. Cortical thinning and flattening in schizophrenia and their unaffected parents[J]. NEUROPSYCHIATRIC DISEASE AND TREATMENT,2019,15:935-946.
APA Yan, Jing.,Cui, Yue.,Li, Qianqian.,Tian, Lin.,Liu, Bing.,...&Yan, Hao.(2019).Cortical thinning and flattening in schizophrenia and their unaffected parents.NEUROPSYCHIATRIC DISEASE AND TREATMENT,15,935-946.
MLA Yan, Jing,et al."Cortical thinning and flattening in schizophrenia and their unaffected parents".NEUROPSYCHIATRIC DISEASE AND TREATMENT 15(2019):935-946.
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