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| Development and validation of an individualized nomogram to identify occult peritoneal metastasis in patients with advanced gastric cancer | |
Dong, D.1,2,3 ; Tang, L.2; Li, Z. -Y4; Fang, M-J1,3; Gao, J-B5; Shan, X-H6; Ying, X-J4; Sun, Y-S2; Fu, J.2; Wang, X-X6; Li, L-M5; Li, Z-H7; Zhang, D-F7; Zhang, Y.4; Li, Z-M4; Shan, F.4; Bu, Z-D4; Tian, J.1,3,8; Ji, J-F4
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| Source Publication | ANNALS OF ONCOLOGY
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| ISSN | 0923-7534 |
| 2019-03-01 | |
| Volume | 30Issue:3Pages:431-438 |
| Corresponding Author | Tian, J.(jie.tian@ia.ac.cn) ; Ji, J-F(jijiafu@hsc.pku.edu.cn) |
| Abstract | Background Occult peritoneal metastasis (PM) in advanced gastric cancer (AGC) patients is highly possible to be missed on computed tomography (CT) images. Patients with occult PMs are subject to late detection or even improper surgical treatment. We therefore aimed to develop a radiomic nomogram to preoperatively identify occult PMs in AGC patients. Patients and methods A total of 554 AGC patients from 4 centers were divided into 1 training, 1 internal validation, and 2 external validation cohorts. All patients' PM status was firstly diagnosed as negative by CT, but later confirmed by laparoscopy (PM-positive n=122, PM-negative n=432). Radiomic signatures reflecting phenotypes of the primary tumor (RS1) and peritoneum region (RS2) were built as predictors of PM from 266 quantitative image features. Individualized nomograms of PM status incorporating RS1, RS2, or clinical factors were developed and evaluated regarding prediction ability. Results RS1, RS2, and Lauren type were significant predictors of occult PM (all P<0.05). A nomogram of these three factors demonstrated better diagnostic accuracy than the model with RS1, RS2, or clinical factors alone (all net reclassification improvement P<0.05). The area under curve yielded was 0.958 [95% confidence interval (CI) 0.923-0.993], 0.941 (95% CI 0.904-0.977), 0.928 (95% CI 0.886-0.971), and 0.920 (95% CI 0.862-0.978) for the training, internal, and two external validation cohorts, respectively. Stratification analysis showed that this nomogram had potential generalization ability. Conclusion CT phenotypes of both primary tumor and nearby peritoneum are significantly associated with occult PM status. A nomogram of these CT phenotypes and Lauren type has an excellent prediction ability of occult PM, and may have significant clinical implications on early detection of occult PM for AGC. |
| Keyword | occult peritoneal metastasis radiomic nomogram advanced gastric cancer |
| DOI | 10.1093/annonc/mdz001 |
| WOS Keyword | BORRMANN TYPE ; RADIOMICS ; CHEMOTHERAPY ; CT |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2017YFC1308700] ; National Key R&D Program of China[2017YFC1309100] ; National Key R&D Program of China[2016YFC0103803] ; National Key R&D Program of China[2017YFA0700401] ; National Natural Science Foundation of China[81771924] ; National Natural Science Foundation of China[81501616] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81671851] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[61622117] ; Beijing Natural Science Foundation[L182061] ; Beijing Natural Science Foundation[Z180001] ; Beijing Municipal Science and Technology Commission[Z171100000117023] ; Beijing Municipal Science and Technology Commission[Z161100002616022] ; Instrument Developing Project of the Chinese Academy of Sciences[YZ201502] ; Youth Innovation Promotion Association CAS[2017175] |
| Funding Organization | National Key R&D Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Municipal Science and Technology Commission ; Instrument Developing Project of the Chinese Academy of Sciences ; Youth Innovation Promotion Association CAS |
| WOS Research Area | Oncology |
| WOS Subject | Oncology |
| WOS ID | WOS:000465084000017 |
| Publisher | OXFORD UNIV PRESS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/24933 |
| Collection | 中国科学院自动化研究所 |
| Corresponding Author | Tian, J.; Ji, J-F |
| Affiliation | 1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China 2.Peking Univ, Key Lab Carcinogenesis & Translat Res, Canc Hosp & Inst, Minist Educ,Radiol Dept, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Peking Univ, Key Lab Carcinogenesis & Translat Res, Gastrointestinal Canc Ctr, Minist Educ,Canc Hosp & Inst, 52 Fu Cheng Rd, Beijing 100142, Peoples R China 5.Zhengzhou Univ, Dept Radiol, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China 6.Jiangsu Univ, Dept Radiol, Affiliated Peoples Hosp, Zhenjiang, Jiangsu, Peoples R China 7.Kunming Med Univ, Yunnan Canc Hosp, Dept Radiol, Affiliated Hosp 3, Kunming, Yunnan, Peoples R China 8.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing, Peoples R China |
| First Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Dong, D.,Tang, L.,Li, Z. -Y,et al. Development and validation of an individualized nomogram to identify occult peritoneal metastasis in patients with advanced gastric cancer[J]. ANNALS OF ONCOLOGY,2019,30(3):431-438. |
| APA | Dong, D..,Tang, L..,Li, Z. -Y.,Fang, M-J.,Gao, J-B.,...&Ji, J-F.(2019).Development and validation of an individualized nomogram to identify occult peritoneal metastasis in patients with advanced gastric cancer.ANNALS OF ONCOLOGY,30(3),431-438. |
| MLA | Dong, D.,et al."Development and validation of an individualized nomogram to identify occult peritoneal metastasis in patients with advanced gastric cancer".ANNALS OF ONCOLOGY 30.3(2019):431-438. |
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