Radiomics Analysis of DTI Data to Assess Vision Outcome After Intravenous Methylprednisolone Therapy in Neuromyelitis Optic Neuritis

doi:10.1002/jmri.26326

	Radiomics Analysis of DTI Data to Assess Vision Outcome After Intravenous Methylprednisolone Therapy in Neuromyelitis Optic Neuritis
	Tian, Yuan 1,4; Liu, Zhenyu2 ; Tang, Zhenchao 2,5; Li, Mingge 1; Lou, Xin 1; Dong, Enqing 5; Liu, Gang 1; Wang, Yulin 1; Wang, Yan 1; Bian, Xiangbin 1; Wei, Shihui 3; Tian, Jie 2,6; Ma, Lin 1
发表期刊	JOURNAL OF MAGNETIC RESONANCE IMAGING
ISSN	1053-1807
	2019-05-01
卷号	49 期号:5 页码:1365-1373
通讯作者	Wei, Shihui(weishihui706@hotmail.com) ; Tian, Jie(jie.tian@ia.ac.cn) ; Ma, Lin(cjr.malin@vip.163.com)
摘要	Background Neuromyelitis optica-optic neuritis (NMO-ON) patients are routinely treated with intravenous methylprednisolone (IVMP). For the patients nonresponsive to IVMP, more effective but aggressive therapy of plasma exchange (PE) should be employed instead of IVMP in the first line. Purpose To assess the visual outcomes of NMO-ON patients after IVMP by radiomics analysis of whole brain diffusion tensor imaging (DTI) data. Study Type Retrospective. Population In all, 57 NMO-ON patients receiving IVMP therapy for 3 days. Field Strength/Sequence 3.0T; DTI images acquired by a single-shot echo planar image sequence; T-1 images acquired by 3D fast spoiled gradient echo (3D-FSPGR) MRI. Assessment In all, 200 DTI measures were extracted from the DTI data and employed as features to construct a radiomics assessment model for visual outcomes of NMO-ON patients after IVMP. The assessment performance was evaluated by area under the receiver operating characteristic curve (AUC), classification accuracy (ACC), sensitivity, specificity, and positive and negative predicted values (PPV and NPV). The selected DTI measures would reveal the white matter impairments related to visual recovery of NMO-ON patients. Statistical Tests The relationship between the selected DTI measures and the clinical visual characteristics were investigated by Pearson correlation, Spearman's rank correlation, and one-way analysis of variance analysis. Results The radiomics model obtained an ACC of 73.68% (P = 0.002), AUC of 0.7931, sensitivity of 0.6207, specificity of 0.8571, PPV of 0.8182, and NPV of 0.6857 in assessing visual outcomes of the NMO-ON patients after IVMP treatment. The selected DTI measures revealed white matter impairments related to the visual outcomes in the white matter tracts of vision-relevant regions, motor-related regions, and corpus callosum. The white matter impairments were found significantly correlated with the disease duration and the length of lesions in the optic nerve. Data Conclusion Radiomics analysis of DTI data has great potential in assessing visual outcomes of NMO-ON patients after IVMP therapy.
关键词	neuromyelitis optica optic neuritis intravenous methylprednisolone radiomics white matter visual outcomes
DOI	10.1002/jmri.26326
关键词[WOS]	WHITE-MATTER ; DIFFUSION ; DAMAGE ; NERVE
收录类别	SCI
语种	英语
资助项目	309th Hospital of Chinese People's Liberation Army[2014ZD-003] ; Beijing Municipal Science & Technology Commission[Z161100002616022] ; Beijing Municipal Science & Technology Commission[Z171100000117023] ; National Natural Science Foundation of China[81772012] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501549] ; National Natural Science Foundation of China[81227901] ; National Key Research and Development Plan of China[2016YFC0103001] ; National Key Research and Development Plan of China[2017YFA0205200] ; National Key Research and Development Plan of China[2017YFA0205200] ; National Key Research and Development Plan of China[2016YFC0103001] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81501549] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81772012] ; Beijing Municipal Science & Technology Commission[Z171100000117023] ; Beijing Municipal Science & Technology Commission[Z161100002616022] ; 309th Hospital of Chinese People's Liberation Army[2014ZD-003]
项目资助者	National Key Research and Development Plan of China ; National Natural Science Foundation of China ; Beijing Municipal Science & Technology Commission ; 309th Hospital of Chinese People's Liberation Army
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000464390200015
出版者	WILEY
七大方向——子方向分类	医学影像处理与分析
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/24955
专题	中国科学院分子影像重点实验室
通讯作者	Wei, Shihui; Tian, Jie; Ma, Lin
作者单位	1.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Dept Ophthalmol, Beijing, Peoples R China 4.Chinese Peoples Liberat Army, Hosp 309, Dept Radiol, Beijing, Peoples R China 5.Shandong Univ, Sch Mech Elect & Informat Engn, Weihai, Shandong, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China
通讯作者单位	中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Tian, Yuan,Liu, Zhenyu,Tang, Zhenchao,et al. Radiomics Analysis of DTI Data to Assess Vision Outcome After Intravenous Methylprednisolone Therapy in Neuromyelitis Optic Neuritis[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2019,49(5):1365-1373.
APA	Tian, Yuan.,Liu, Zhenyu.,Tang, Zhenchao.,Li, Mingge.,Lou, Xin.,...&Ma, Lin.(2019).Radiomics Analysis of DTI Data to Assess Vision Outcome After Intravenous Methylprednisolone Therapy in Neuromyelitis Optic Neuritis.JOURNAL OF MAGNETIC RESONANCE IMAGING,49(5),1365-1373.
MLA	Tian, Yuan,et al."Radiomics Analysis of DTI Data to Assess Vision Outcome After Intravenous Methylprednisolone Therapy in Neuromyelitis Optic Neuritis".JOURNAL OF MAGNETIC RESONANCE IMAGING 49.5(2019):1365-1373.