| Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder | |
Yang, Yongfeng1,2,3; Liu, Shu4,5 ; Jiang, Xiaoyan1; Yu, Hongyan2; Ding, Shuang2,3; Lu, Yanli2,3; Li, Wenqiang2,3; Zhang, Hongxing2,3; Liu, Bing4,5,6; Cui, Yue4,5,6; Fan, Lingzhong4,5,6; Jiang, Tianzi1,4,5,6,7; Lv, Luxian2,3
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| 发表期刊 | FRONTIERS IN PSYCHIATRY
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| ISSN | 1664-0640 |
| 2019-02-19 | |
| 卷号 | 10页码:10 |
| 通讯作者 | Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) ; Lv, Luxian(lvx928@126.com) |
| 摘要 | Objectives: Schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD) are serious mental disorders with distinct diagnostic criteria. They share common clinical and biological features. However, there are still only few studies on the common and specific brain imaging changes associated with the three mental disorders. Therefore, the aim of this study was to identify the common and specific functional activity and connectivity changes in SZ, MDD, and BD. Methods: A total of 271 individuals underwent functional magnetic resonance imaging: SZ (n = 64), MDD (n= 73), BD (n = 41), and healthy controls (n = 93). The symptoms of SZ patients were evaluated by the Positive and Negative Syndrome Scale. The Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were used to evaluate the symptoms of MDD patients. The BDI, BAI, and Young Mania Rating Scale were used to evaluate the symptoms of MDD and BD patients. In addition, we compared the fALFF and functional connectivity between the three mental disorders and healthy controls using two sample t-tests. Results: Significantly decreased functional activity was found in the right superior frontal gyrus, middle cingulate gyrus, left middle frontal gyrus, and decreased functional connectivity (FC) of the insula was found in SZ, MDD, and BD. Specific fALFF changes, mainly in the ventral lateral pre-frontal cortex, striatum, and thalamus were found for SZ, in the left motor cortex and parietal lobe for MDD, and the dorsal lateral pre-frontal cortex, orbitofrontal cortex, and posterior cingulate cortex in BD. Conclusion: Our findings of common abnormalities in SZ, MDD, and BD provide evidence that salience network abnormality may play a critical role in the pathogenesis of these three mental disorders. Meanwhile, our findings also indicate that specific alterations in SZ, MDD, and BD provide neuroimaging evidence for the differential diagnosis of the three mental disorders. |
| 关键词 | schizophrenia major depressive disorder bipolar disorder magnetic resonance imaging functional activity |
| DOI | 10.3389/fpsyt.2019.00052 |
| 关键词[WOS] | LOW-FREQUENCY FLUCTUATION ; ANTERIOR CINGULATE CORTEX ; DEFAULT MODE NETWORK ; GLOBAL SIGNAL ; PREFRONTAL CORTEX ; CONNECTIVITY ; AMPLITUDE ; SCALE ; NEUROANATOMY ; RELIABILITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[81671330] ; National Key Research and Development Program of China[2016YFC0904301] ; National Key Research and Development Program of China[2016YFC1307001] ; Medical Science and Technology Research Project of Henan Province[201702131] ; Medical Science and Technology Research Project of Henan Province[2018020373] ; Open Project Program of the Henan Key Lab of Biological Psychiatry[ZDSYS2015001] ; High Scientific and Technological Research Fund of Xinxiang Medical University[2017ZDCG-04] ; Training plan for young excellent teachers in Colleges and Universities of Henan[2016GGJS-106] ; Xinxiang Medical University ; National Natural Science Foundation of China[81671330] ; National Key Research and Development Program of China[2016YFC0904301] ; National Key Research and Development Program of China[2016YFC1307001] ; Medical Science and Technology Research Project of Henan Province[201702131] ; Medical Science and Technology Research Project of Henan Province[2018020373] ; Open Project Program of the Henan Key Lab of Biological Psychiatry[ZDSYS2015001] ; High Scientific and Technological Research Fund of Xinxiang Medical University[2017ZDCG-04] ; Training plan for young excellent teachers in Colleges and Universities of Henan[2016GGJS-106] ; Xinxiang Medical University |
| 项目资助者 | National Natural Science Foundation of China ; National Key Research and Development Program of China ; Medical Science and Technology Research Project of Henan Province ; Open Project Program of the Henan Key Lab of Biological Psychiatry ; High Scientific and Technological Research Fund of Xinxiang Medical University ; Training plan for young excellent teachers in Colleges and Universities of Henan ; Xinxiang Medical University |
| WOS研究方向 | Psychiatry |
| WOS类目 | Psychiatry |
| WOS记录号 | WOS:000459124800001 |
| 出版者 | FRONTIERS MEDIA SA |
| 七大方向——子方向分类 | 脑网络分析 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/25043 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 通讯作者 | Jiang, Tianzi; Lv, Luxian |
| 作者单位 | 1.Univ Elect Sci & Technol China, Key Lab Neuroinformat, Minist Educ, Sch Life Sci & Technol, Chengdu, Sichuan, Peoples R China 2.Xinxiang Med Univ, Dept Psychiat, Henan Mental Hosp, Affiliated Hosp 2, Xinxiang, Peoples R China 3.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China 4.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 5.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia |
| 通讯作者单位 | 模式识别国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yang, Yongfeng,Liu, Shu,Jiang, Xiaoyan,et al. Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder[J]. FRONTIERS IN PSYCHIATRY,2019,10:10. |
| APA | Yang, Yongfeng.,Liu, Shu.,Jiang, Xiaoyan.,Yu, Hongyan.,Ding, Shuang.,...&Lv, Luxian.(2019).Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder.FRONTIERS IN PSYCHIATRY,10,10. |
| MLA | Yang, Yongfeng,et al."Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder".FRONTIERS IN PSYCHIATRY 10(2019):10. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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