Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study

doi:10.1007/s00234-018-2104-3

	Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study
	Zhang, Miao 1; Wang, Shengpei2,3 ; Hu, Di 1; Kang, Huiying 1; Ouyang, Minhui 4; Zhang, Yonghong 5; Rao, Bo 1; Huang, Hao 4,6; Peng, Yun 1
发表期刊	NEURORADIOLOGY
ISSN	0028-3940
	2019
卷号	61 期号:1 页码:63-70
通讯作者	Peng, Yun(ppengyun@yahoo.com)
摘要	PurposePrevious studies have investigated the brain structural abnormalities in children with type I Gaucher disease (GD). The purpose of our study is to investigate the topological efficiency of the brain functional network in children with type 1 GD.MethodsTwenty-two children diagnosed with type 1 GD and 22 sex- and age-matched healthy controls (HCs) underwent resting-state functional MRI (rs-fMRI) examination. For longitudinal study, the GD patients underwent rs-fMRI examination again after 4.6years. Graph theoretical analysis was used to assess the brain network topological properties at the global and regional levels.ResultsCompared with the HCs, the children with type 1 GD showed a decreased efficiency in functional segregation with a decreased (normalized clustering coefficient). In addition, the balance between functional segregation and integration was disrupted with decreased small-worldness (sigma). At the regional level, the children with type 1 GD showed significantly decreased nodal degree and efficiency in the right precentral gyrus (PreCG.R) and left postcentral gyrus (PoCG.L). The significantly altered , sigma, and nodal degree in the PreCG.R and PoCG.L were negatively correlated with the disease duration. No significant alterations in the global and regional topological properties were identified in these patients over time.ConclusionCompared with that of the HCs, the efficiency of the brain functional network in the children with type 1 GD was disrupted, and regional involvement was located in motor- and sensory-related regions. The efficiency of the brain functional network in these patients remained stable over time.
关键词	Gaucher disease Children Resting-state functional MRI Brain functional networks Graph theory
DOI	10.1007/s00234-018-2104-3
关键词[WOS]	CONNECTIVITY NETWORKS ; PERIPHERAL NEUROPATHY ; ORGANIZATION ; DIAGNOSIS ; TOPOLOGY
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81671651] ; National Natural Science Foundation of China[81671651]
项目资助者	National Natural Science Foundation of China
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000456076500012
出版者	SPRINGER
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/25342
专题	脑图谱与类脑智能实验室_神经计算与脑机交互
通讯作者	Peng, Yun
作者单位	1.Capital Med Univ, Natl Ctr Childrens Hlth, Beijing Childrens Hosp, Dept Radiol, Beijing 100045, Peoples R China 2.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Childrens Hosp Philadelphia, Dept Radiol, Philadelphia, PA 19104 USA 5.Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Hematol Oncol Ctr, Beijing 100045, Peoples R China 6.Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA
推荐引用方式 GB/T 7714	Zhang, Miao,Wang, Shengpei,Hu, Di,et al. Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study[J]. NEURORADIOLOGY,2019,61(1):63-70.
APA	Zhang, Miao.,Wang, Shengpei.,Hu, Di.,Kang, Huiying.,Ouyang, Minhui.,...&Peng, Yun.(2019).Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study.NEURORADIOLOGY,61(1),63-70.
MLA	Zhang, Miao,et al."Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study".NEURORADIOLOGY 61.1(2019):63-70.