CASIA OpenIR
Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study
Zhang, Miao1; Wang, Shengpei2,3; Hu, Di1; Kang, Huiying1; Ouyang, Minhui4; Zhang, Yonghong5; Rao, Bo1; Huang, Hao4,6; Peng, Yun1
Source PublicationNEURORADIOLOGY
ISSN0028-3940
2019
Volume61Issue:1Pages:63-70
Corresponding AuthorPeng, Yun(ppengyun@yahoo.com)
AbstractPurposePrevious studies have investigated the brain structural abnormalities in children with type I Gaucher disease (GD). The purpose of our study is to investigate the topological efficiency of the brain functional network in children with type 1 GD.MethodsTwenty-two children diagnosed with type 1 GD and 22 sex- and age-matched healthy controls (HCs) underwent resting-state functional MRI (rs-fMRI) examination. For longitudinal study, the GD patients underwent rs-fMRI examination again after 4.6years. Graph theoretical analysis was used to assess the brain network topological properties at the global and regional levels.ResultsCompared with the HCs, the children with type 1 GD showed a decreased efficiency in functional segregation with a decreased (normalized clustering coefficient). In addition, the balance between functional segregation and integration was disrupted with decreased small-worldness (sigma). At the regional level, the children with type 1 GD showed significantly decreased nodal degree and efficiency in the right precentral gyrus (PreCG.R) and left postcentral gyrus (PoCG.L). The significantly altered , sigma, and nodal degree in the PreCG.R and PoCG.L were negatively correlated with the disease duration. No significant alterations in the global and regional topological properties were identified in these patients over time.ConclusionCompared with that of the HCs, the efficiency of the brain functional network in the children with type 1 GD was disrupted, and regional involvement was located in motor- and sensory-related regions. The efficiency of the brain functional network in these patients remained stable over time.
KeywordGaucher disease Children Resting-state functional MRI Brain functional networks Graph theory
DOI10.1007/s00234-018-2104-3
WOS KeywordCONNECTIVITY NETWORKS ; PERIPHERAL NEUROPATHY ; ORGANIZATION ; DIAGNOSIS ; TOPOLOGY
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81671651]
Funding OrganizationNational Natural Science Foundation of China
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectClinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000456076500012
PublisherSPRINGER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/25342
Collection中国科学院自动化研究所
Corresponding AuthorPeng, Yun
Affiliation1.Capital Med Univ, Natl Ctr Childrens Hlth, Beijing Childrens Hosp, Dept Radiol, Beijing 100045, Peoples R China
2.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Childrens Hosp Philadelphia, Dept Radiol, Philadelphia, PA 19104 USA
5.Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Hematol Oncol Ctr, Beijing 100045, Peoples R China
6.Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA
Recommended Citation
GB/T 7714
Zhang, Miao,Wang, Shengpei,Hu, Di,et al. Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study[J]. NEURORADIOLOGY,2019,61(1):63-70.
APA Zhang, Miao.,Wang, Shengpei.,Hu, Di.,Kang, Huiying.,Ouyang, Minhui.,...&Peng, Yun.(2019).Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study.NEURORADIOLOGY,61(1),63-70.
MLA Zhang, Miao,et al."Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study".NEURORADIOLOGY 61.1(2019):63-70.
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