Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

doi:10.1021/acsnano.8b06399

	Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics
	Wang, Shuaifei 1; Li, Fangyuan 1; Qiao, Ruirui 4; Hu, Xi 1; Liao, Honrei 1; Chen, Lumin 6; Wu, Jiahe 1; Wu, Haibin 1; Zhao, Meng 1,2; Liu, Jianan 9; Chen, Rui7 ; Ma, Xibo8 ; Kim, Dokyoon 9; Sun, Jihong 6; Davis, Thomas P.4,5; Chen, Chunying 7; Tian, Jie 8; Hyeon, Taeghwan 9,10; Ling, Daishun 1,2,3
发表期刊	ACS NANO
ISSN	1936-0851
	2018-12-01
卷号	12 期号:12 页码:12380-12392
通讯作者	Ling, Daishun(lingds@zju.edu.cn)
摘要	Ferroptosis, an iron-based cell-death pathway, has recently attracted great attention owing to its effectiveness in killing cancer cells. Previous investigations focused on the development of iron-based nanomaterials to induce ferroptosis in cancer cells by the up-regulation of reactive oxygen species (ROS) generated by the well-known Fenton reaction. Herein, we report a ferroptosis-inducing agent based on arginine-rich manganese silicate nanobubbles (AMSNs) that possess highly efficient glutathione (GSH) depletion ability and thereby induce ferroptosis by the inactivation of glutathione-dependent peroxidases 4 (GPX4). The AMSNs were synthesized via a one-pot reaction with arginine (Arg) as the surface ligand for tumor homing. Subsequently, a significant tumor suppression effect can be achieved by GSH depletion-induced ferroptosis. Moreover, the degradation of AMSNs during the GSH depletion contributed to T-1-weighted magnetic resonance imaging (MRI) enhancement as well as on-demand chemotherapeutic drug release for synergistic cancer therapy. We anticipate that the GSH-depletion-induced ferroptosis strategy by using manganese-based nanomaterials would provide insights in designing nanomedicines for tumor-targeted theranostics.
关键词	nanobubbles glutathione GPX4 ferroptosis theranostics
DOI	10.1021/acsnano.8b06399
关键词[WOS]	CANCER-CELLS ; OXIDE NANOPARTICLES ; GLUTATHIONE LEVELS ; CONTRAST ; THERAPY ; DEATH ; ACTIVATION ; GENERATION ; BIOLOGY ; PATHWAY
收录类别	SCI
语种	英语
资助项目	Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology[CE140100036] ; Research Center Program for the Institute of Basic Science[IBS-R006-D1] ; Fundamental Research Funds for the Central Universities[2017XZZX001-04] ; Fundamental Research Funds for the Central Universities[2018QNA7020] ; Thousand Talents Program for Distinguished Young Scholars ; National Natural Science Foundation of China[81430040] ; National Natural Science Foundation of China[21777036] ; National Natural Science Foundation of China[81471739] ; National Natural Science Foundation of China[51703195] ; National Natural Science Foundation of China[51611540345] ; National Natural Science Foundation of China[51503180] ; National Natural Science Foundation of China[31822019] ; National Key Research and Development Program of China[2016YFA0201600] ; National Key Research and Development Program of China[2016YFA0100900] ; National Key Research and Development Program of China[2016YFA0203600] ; National Key Research and Development Program of China[2016YFA0203600] ; National Key Research and Development Program of China[2016YFA0100900] ; National Key Research and Development Program of China[2016YFA0201600] ; National Natural Science Foundation of China[31822019] ; National Natural Science Foundation of China[51503180] ; National Natural Science Foundation of China[51611540345] ; National Natural Science Foundation of China[51703195] ; National Natural Science Foundation of China[81471739] ; National Natural Science Foundation of China[21777036] ; National Natural Science Foundation of China[81430040] ; Thousand Talents Program for Distinguished Young Scholars ; Fundamental Research Funds for the Central Universities[2018QNA7020] ; Fundamental Research Funds for the Central Universities[2017XZZX001-04] ; Research Center Program for the Institute of Basic Science[IBS-R006-D1] ; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology[CE140100036]
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Thousand Talents Program for Distinguished Young Scholars ; Fundamental Research Funds for the Central Universities ; Research Center Program for the Institute of Basic Science ; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000454567500061
出版者	AMER CHEMICAL SOC
引用统计	被引频次：296[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/25638
专题	中国科学院分子影像重点实验室
通讯作者	Ling, Daishun
作者单位	1.Zhejiang Univ, Inst Pharmaceut, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China 2.Zhejiang Univ, Hangzhou Inst Innovat Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China 3.Zhejiang Univ, Key Lab Biomed Engn, Minist Educ, Coll Biomed Engn & Instrument Sci, Hangzhou 310058, Zhejiang, Peoples R China 4.Monash Univ, ARC Ctr Excellence Convergent Bionano Sci & Techn, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia 5.Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England 6.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Hangzhou 310058, Zhejiang, Peoples R China 7.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 8.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 9.Inst for Basic Sci Korea, Ctr Nanoparticle Res, Seoul 08826, South Korea 10.Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 08826, South Korea
推荐引用方式 GB/T 7714	Wang, Shuaifei,Li, Fangyuan,Qiao, Ruirui,et al. Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics[J]. ACS NANO,2018,12(12):12380-12392.
APA	Wang, Shuaifei.,Li, Fangyuan.,Qiao, Ruirui.,Hu, Xi.,Liao, Honrei.,...&Ling, Daishun.(2018).Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics.ACS NANO,12(12),12380-12392.
MLA	Wang, Shuaifei,et al."Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics".ACS NANO 12.12(2018):12380-12392.