Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Optimization and Design of Magnetic Ferrite Nanoparticles with Uniform Tumor Distribution for Highly Sensitive MRI/MPI Performance and Improved Magnetic Hyperthermia Therapy | |
Du, Yang1,2![]() ![]() | |
发表期刊 | NANO LETTERS
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ISSN | 1530-6984 |
2019-06-01 | |
卷号 | 19期号:6页码:3618-3626 |
通讯作者 | Liang, Xing-Jie(liangxj@nanoctr.cn) ; Tian, Jie(jie.tian@ia.ac.cn) |
摘要 | Two major technical challenges of magnetic hyperthermia are quantitative assessment of agent distribution during and following administration and achieving uniform heating of the tumor at the desired temperature without damaging the surrounding tissues. In this study, we developed a multimodal MRI/MPI theranostic agent with active biological targeting for improved magnetic hyperthermia therapy (MHT). First, by systematically elucidating the magnetic nanoparticle magnetic characteristics and the magnetic resonance imaging (MRI) and magnetic particle imaging (MPI) signal enhancement effects, which are based on the magnetic anisotropy, size, and type of nanoparticles, we found that 18 nm iron oxide NPs (IOs) could be used as superior nanocrystallines for high performance of MRI/MPI contrast agents in vitro. To improve the delivery uniformity, we then targeted tumors with the 18 nm IOs using a tumor targeting peptide, CREKA. Both MRI and MPI signals showed that the targeting agent improves the intratumoral delivery uniformity of nanoparticles in a 4T1 orthotopic mouse breast cancer model. Lastly, the in vivo antitumor MHT effect was evaluated, and the data showed that the improved targeting and delivery uniformity enables more effective magnetic hyperthermia cancer ablation than otherwise identical, nontargeting IOs. This preclinical study of image-guided MHT using cancer-targeting IOs and a novel MPI system paves the way for new MHT strategies. |
关键词 | Magnetic hyperthermia therapy (MHT) magnetic resonance imaging (MRI) magnetic particle imaging (MPI) magnetic ferrite nanoparticles (MFNPs) theranostics |
DOI | 10.1021/acs.nanolett.9b00630 |
关键词[WOS] | IRON-OXIDE NANOPARTICLES ; MRI ; NANOMATERIALS ; ENHANCEMENT ; NANORINGS ; PLATFORM ; AGENT ; MPI ; T-1 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Natural Science Foundation[31430031] ; Natural Science Foundation[31630027] ; Beijing Municipal Science and Technology Commission[Z171100000117023] ; Beijing Municipal Science and Technology Commission[Z161100002616022] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Chinese Academy of Sciences[GJJSTD20170004] ; NSFC-DFG project[31761133013] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81871514] ; Ministry of Science and Technology of China[2017YFA0700401] ; Ministry of Science and Technology of China[2017YFA0205200] ; Ministry of Science and Technology of China[2017YFA0205200] ; Ministry of Science and Technology of China[2017YFA0700401] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81470083] ; NSFC-DFG project[31761133013] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Beijing Municipal Science and Technology Commission[Z161100002616022] ; Beijing Municipal Science and Technology Commission[Z171100000117023] ; Natural Science Foundation[31630027] ; Natural Science Foundation[31430031] |
项目资助者 | Ministry of Science and Technology of China ; National Natural Science Foundation of China ; NSFC-DFG project ; Chinese Academy of Sciences ; Beijing Municipal Science and Technology Commission ; Natural Science Foundation |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
WOS记录号 | WOS:000471834900029 |
出版者 | AMER CHEMICAL SOC |
七大方向——子方向分类 | 其他 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/26003 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Liang, Xing-Jie; Tian, Jie |
作者单位 | 1.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11,First North Rd, Beijing 100190, Peoples R China 4.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100190, Peoples R China 5.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710126, Shaanxi, Peoples R China |
第一作者单位 | 中国科学院自动化研究所 |
通讯作者单位 | 中国科学院自动化研究所 |
推荐引用方式 GB/T 7714 | Du, Yang,Liu, Xiaoli,Liang, Qian,et al. Optimization and Design of Magnetic Ferrite Nanoparticles with Uniform Tumor Distribution for Highly Sensitive MRI/MPI Performance and Improved Magnetic Hyperthermia Therapy[J]. NANO LETTERS,2019,19(6):3618-3626. |
APA | Du, Yang,Liu, Xiaoli,Liang, Qian,Liang, Xing-Jie,&Tian, Jie.(2019).Optimization and Design of Magnetic Ferrite Nanoparticles with Uniform Tumor Distribution for Highly Sensitive MRI/MPI Performance and Improved Magnetic Hyperthermia Therapy.NANO LETTERS,19(6),3618-3626. |
MLA | Du, Yang,et al."Optimization and Design of Magnetic Ferrite Nanoparticles with Uniform Tumor Distribution for Highly Sensitive MRI/MPI Performance and Improved Magnetic Hyperthermia Therapy".NANO LETTERS 19.6(2019):3618-3626. |
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