High-efficiency fluorescent and magnetic multimodal probe for long-term monitoring and deep penetration imaging of tumors

doi:10.1039/c9tb00638a

	High-efficiency fluorescent and magnetic multimodal probe for long-term monitoring and deep penetration imaging of tumors
	Meng, Lingchen 1; Ma, Xibo2,3 ; Jiang, Shan 1; Ji, Guang 1; Han, Wenkun 1; Xu, Bin 1; Tian, Jie 2,3; Tian, Wenjing 1
发表期刊	JOURNAL OF MATERIALS CHEMISTRY B
ISSN	2050-750X
	2019-09-21
卷号	7 期号:35 页码:5345-5351
通讯作者	Tian, Jie() ; Tian, Wenjing(wjtian@jlu.edu.cn)
摘要	High-quality multimodal imaging requires exogenous contrast agents with high sensitivity, spatial-temporal resolution, and high penetration depth for the accurate diagnosis and surveillance of cancer. Herein, we design a highly efficient fluorescent and magnetic multimodal probe by doping fluorescent molecule 2-(4-bromophenyl)-3-(4-(4-(diphenylamino)styryl)phenyl)fumaronitrile (TB) with near-infrared (NIR) fluorescent emission (714 nm) and superparamagnetic iron oxide (SPIO) into a polystyrene-polyethylene glycol (PS-PEG) matrix to form TB/SPIO@PS-PEG nanoparticles (TSP NPs). The as-prepared TSP NPs exhibit red aggregation-induced emission (AIE) with a maximum wavelength at 655 nm and high fluorescence quantum yield (QY) of 14.6%, facilitating the improvement of sensitivity and signal-to-background ratio for fluorescence molecular imaging (FMI). Phase behavior investigation of the TB/SPIO@PS-PEG probe system by Flory-Huggins lattice theory elucidates the highly efficient fluorescence of the multimodal probe, originating from the poor miscibility between TB and SPIO. Meanwhile, the TSP NPs possess good superparamagnetism and relaxivity and can thus be used as appropriate magnetic contrast agents for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI). In addition, the good biocompatibility and photostability of the TSP NPs make them suitable for long-term monitoring. In vivo fluorescence imaging results indicate that the TSP NPs can facilitate monitoring of subcutaneous tumor growth for more than 24 days in a real-time manner. Multimodal imaging consisting of FMI, MRI, and MPI reveals that TSP NPs can monitor a liver tumor in situ with almost unlimited depth in tissues and high temporal-spatial resolution. As a multimodal probe, the TSP NPs manifest obvious synergistic advantages of long-term monitoring and high penetration depth and hold great prospects in tumor imaging.
DOI	10.1039/c9tb00638a
关键词[WOS]	AGGREGATION-INDUCED EMISSION ; TURN-ON DETECTION ; NANOPARTICLES ; MISCIBILITY ; AGENT
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of China[21835001] ; Natural Science Foundation of China[21674041] ; Natural Science Foundation of China[51773080] ; Natural Science Foundation of China[51573068] ; Natural Science Foundation of China[21221063] ; Natural Science Foundation of China[81871442] ; National Key Research programs of China[2016YFA0100900] ; National Key Research programs of China[2016YFA0100902] ; National Key Research programs of China[2017YFA0205200] ; Program for Changbaishan Scholars of Jilin Province ; ''Talents Cultivation Program'' of Jilin University ; Jilin Province project[20160101305JC] ; Natural Science Foundation of China[21835001] ; Natural Science Foundation of China[21674041] ; Natural Science Foundation of China[51773080] ; Natural Science Foundation of China[51573068] ; Natural Science Foundation of China[21221063] ; Natural Science Foundation of China[81871442] ; National Key Research programs of China[2016YFA0100900] ; National Key Research programs of China[2016YFA0100902] ; National Key Research programs of China[2017YFA0205200] ; Program for Changbaishan Scholars of Jilin Province ; ''Talents Cultivation Program'' of Jilin University ; Jilin Province project[20160101305JC]
项目资助者	Natural Science Foundation of China ; National Key Research programs of China ; Program for Changbaishan Scholars of Jilin Province ; ''Talents Cultivation Program'' of Jilin University ; Jilin Province project
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:000486046100007
出版者	ROYAL SOC CHEMISTRY
七大方向——子方向分类	其他
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/27285
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Tian, Wenjing
作者单位	1.Jilin Univ, State Key Lab Supramol Struct & Mat, Changchun 130012, Jilin, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Meng, Lingchen,Ma, Xibo,Jiang, Shan,et al. High-efficiency fluorescent and magnetic multimodal probe for long-term monitoring and deep penetration imaging of tumors[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(35):5345-5351.
APA	Meng, Lingchen.,Ma, Xibo.,Jiang, Shan.,Ji, Guang.,Han, Wenkun.,...&Tian, Wenjing.(2019).High-efficiency fluorescent and magnetic multimodal probe for long-term monitoring and deep penetration imaging of tumors.JOURNAL OF MATERIALS CHEMISTRY B,7(35),5345-5351.
MLA	Meng, Lingchen,et al."High-efficiency fluorescent and magnetic multimodal probe for long-term monitoring and deep penetration imaging of tumors".JOURNAL OF MATERIALS CHEMISTRY B 7.35(2019):5345-5351.