Improved Red Emission and Short-Wavelength Infrared Luminescence under 808 nm Laser for Tumor Theranostics

doi:10.1021/acsbiomaterials.9b00688

CASIA OpenIR

	Improved Red Emission and Short-Wavelength Infrared Luminescence under 808 nm Laser for Tumor Theranostics
	Lv, Ruichan 1; Feng, Miao 1; Liu, Jun 1; Jiang, Xue 1; Yuan, Huijuan 1; Yan, Ruyu 1; Tian, Jie 1,2
发表期刊	ACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN	2373-9878
	2019-09-01
卷号	5 期号:9 页码:4683-4691
通讯作者	Lv, Ruichan(rclv@xidian.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要	In this research, a multimodal imaging platform guided photodynamic theranostics under 808 nm was designed using a NaErF4:Tm@NaYF4:Yb@NaLuF4:Nd,Yb-ZnPc structure. Unlike conventional codoped Yb3+/Er3+ system, Er3+ ions as activator and sensitizer were used to improve the up-conversion energy transfer processes. Furthermore, higher energy transfer processes between Er3+ ions could be obtained through doped 1% Tm3+ ions as an energy trapping center in the NaErF4. This platform could emit much brighter upconversion luminescence (UCL) (124-fold enhancement for red emission) and short wavelength infrared (SWIR) emission under single 808 nm laser excitation. Importantly, the SWIR imaging with higher resolution and better signal-to-noise ratio can pass the blood-brain barrier to see the brain vessels. Because of the enhanced red emission, the UCL nanoparticles were combined with ZnPc agent to exhibit photodynamic therapy (PDT) effect, and its distribution and excretion could be detected by the photoacoustic (PA) imaging under single near-infrared (NIR) laser. Thus, this platform could be used as multimodal imaging (SWIR, PA, CT, and UCL) guided PDT agent under single 808 nm laser.
关键词	up conversion luminescence short wavelength infrared photoacoustic multimodal imaging lanthanide nanoparticles
DOI	10.1021/acsbiomaterials.9b00688
关键词[WOS]	UP-CONVERSION NANOPARTICLES ; PHOTON-UPCONVERTING NANOPARTICLES ; PHOTODYNAMIC THERAPY ; ENERGY-TRANSFER ; IN-VIVO ; SINGLE ; NANOCRYSTALS ; STRATEGY ; NANOSTRUCTURES ; EXCITATION
收录类别	SCI
语种	英语
资助项目	Fundamental Research Funds for the Central Universities[JBX181202] ; Fundamental Research Funds for the Central Universities[XJS17011] ; National Key R&D Program of China[2017YFA0205202] ; Natural Science Foundation of China[81227901] ; Natural Science Foundation of China[NSFC 81801744] ; Natural Science Foundation of China[NSFC 81801744] ; Natural Science Foundation of China[81227901] ; National Key R&D Program of China[2017YFA0205202] ; Fundamental Research Funds for the Central Universities[XJS17011] ; Fundamental Research Funds for the Central Universities[JBX181202]
项目资助者	Natural Science Foundation of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central Universities
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:000485210900048
出版者	AMER CHEMICAL SOC
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/27287
通讯作者	Lv, Ruichan; Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Lv, Ruichan,Feng, Miao,Liu, Jun,et al. Improved Red Emission and Short-Wavelength Infrared Luminescence under 808 nm Laser for Tumor Theranostics[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2019,5(9):4683-4691.
APA	Lv, Ruichan.,Feng, Miao.,Liu, Jun.,Jiang, Xue.,Yuan, Huijuan.,...&Tian, Jie.(2019).Improved Red Emission and Short-Wavelength Infrared Luminescence under 808 nm Laser for Tumor Theranostics.ACS BIOMATERIALS SCIENCE & ENGINEERING,5(9),4683-4691.
MLA	Lv, Ruichan,et al."Improved Red Emission and Short-Wavelength Infrared Luminescence under 808 nm Laser for Tumor Theranostics".ACS BIOMATERIALS SCIENCE & ENGINEERING 5.9(2019):4683-4691.