Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder | |
Liu, Yaou1,2,3,4; Dong, Di5,6; Zhang, Liwen5,6; Zang, Yali5,6; Duan, Yunyun1,2; Qiu, Xiaolu4; Huang, Jing4; Dong, Huiqing7; Barkhof, Frederik3,8; Hu, Chaoen5,6; Fang, Mengjie5,6; Tian, Jie5,6; Li, Kuncheng1,4 | |
发表期刊 | EUROPEAN RADIOLOGY |
ISSN | 0938-7994 |
2019-09-01 | |
卷号 | 29期号:9页码:4670-4677 |
摘要 | Objective To develop and validate an individual radiomics nomogram for differential diagnosis between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Methods We retrospectively collected 67 MS and 68 NMOSD with spinal cord lesions as a primary cohort and prospectively recruited 28 MS and 26 NMOSD patients as a validation cohort. Radiomic features were extracted from the spinal cord lesions. A prediction model for differentiating MS and NMOSD was built by combining the radiomic features with several clinical and routine MRI measurements. The performance of the model was assessed with respect to its calibration plot and clinical discrimination in the primary and validation cohorts. Results Nine radiomics features extracted from an initial set of 485, predominantly reflecting lesion heterogeneity, combined with lesion length, patient sex, and EDSS, were selected to build the model for differentiating MS and NMOSD. The areas under the ROC curves (AUC) for differentiating the two diseases were 0.8808 and 0.7115, for the primary and validation cohort, respectively. This model demonstrated good calibration (C-index was 0.906 and 0.802 in primary and validation cohort). Conclusions A validated nomogram that incorporates the radiomic signature of spinal cord lesions, as well as cord lesion length, sex, and EDSS score, can usefully differentiate MS and NMOSD. |
关键词 | Multiple sclerosis Neuromyelitis optica spectrum disorder Radiomics Nomogram Magnetic resonance imaging |
DOI | 10.1007/s00330-019-06026-w |
关键词[WOS] | SPINAL-CORD ; BRAIN ; MRI ; FEATURES ; NOMOGRAM ; IMAGES ; SEX |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period[2012BAI10B04] ; Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support[ZYLX201609] ; Beijing Nova Programme[xx2013045] ; Beijing Natural Science fund[7133244] ; National Basic Research Program of China[2013CB966900] ; National Science Foundation of China[81230028] ; National Science Foundation of China[81471221] ; National Science Foundation of China[81401377] ; National Science Foundation of China[61231004] ; National Science Foundation of China[81501736] ; National Science Foundation of China[81771924] ; National Science Foundation of China[81227901] ; National Science Foundation of China[81101038] ; ECTRIMS-MAGNMIS Fellowship from ECTRIMS ; National Key R&D Program of China[2017YFC1308701] ; National Key R&D Program of China[2017YFC1308700] ; Science and Technology Service Network Initiative of the Chinese Academy of Sciences[KFJ-SW-STS-160] ; National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2017YFA0205200] ; Science and Technology Service Network Initiative of the Chinese Academy of Sciences[KFJ-SW-STS-160] ; National Key R&D Program of China[2017YFC1308700] ; National Key R&D Program of China[2017YFC1308701] ; ECTRIMS-MAGNMIS Fellowship from ECTRIMS ; National Science Foundation of China[81101038] ; National Science Foundation of China[81227901] ; National Science Foundation of China[81771924] ; National Science Foundation of China[81501736] ; National Science Foundation of China[61231004] ; National Science Foundation of China[81401377] ; National Science Foundation of China[81471221] ; National Science Foundation of China[81230028] ; National Basic Research Program of China[2013CB966900] ; Beijing Natural Science fund[7133244] ; Beijing Nova Programme[xx2013045] ; Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support[ZYLX201609] ; Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period[2012BAI10B04] |
WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000478873300015 |
出版者 | SPRINGER |
七大方向——子方向分类 | 医学影像处理与分析 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/27584 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Liu, Yaou; Tian, Jie |
作者单位 | 1.Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R China 2.China Natl Clin Res Ctr Neurol Dis, Tiantan Image Res Ctr, Beijing 100050, Peoples R China 3.Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, Neurosci Campus Amsterdam, NL-1007 MB Amsterdam, Netherlands 4.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 5.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China 8.UCL, Inst Neurol & Healthcare Engn, London, England |
通讯作者单位 | 中国科学院自动化研究所 |
推荐引用方式 GB/T 7714 | Liu, Yaou,Dong, Di,Zhang, Liwen,et al. Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder[J]. EUROPEAN RADIOLOGY,2019,29(9):4670-4677. |
APA | Liu, Yaou.,Dong, Di.,Zhang, Liwen.,Zang, Yali.,Duan, Yunyun.,...&Li, Kuncheng.(2019).Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder.EUROPEAN RADIOLOGY,29(9),4670-4677. |
MLA | Liu, Yaou,et al."Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder".EUROPEAN RADIOLOGY 29.9(2019):4670-4677. |
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