FOXO Transcriptional Factors and Long-Term Living

doi:10.1155/2017/3494289

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	FOXO Transcriptional Factors and Long-Term Living
	Murtaza, Ghulam 1,2,3; Khan, Abida Kalsoom 4; Rashid, Rehana 4; Muneer, Saiqa 5; Hasan, Syed Muhammad Farid 6; Chen, Jianxin 1
发表期刊	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
ISSN	1942-0900
	2017
页码	8
通讯作者	Murtaza, Ghulam(gmdogar356@gmail.com) ; Chen, Jianxin(cjx@bucm.edu.cn)
摘要	Several pathologies such as neurodegeneration and cancer are associated with aging, which is affected by many genetic and environmental factors. Healthy aging conceives human longevity, possibly due to carrying the defensive genes. For instance, FOXO (forkhead box O) genes determine human longevity. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. Only one FOXO gene (FOXO DAF-16) exists in invertebrates, while four FOXO genes, that is, FOXO1, FOXO3, FOXO4, and FOXO6 are found in mammals. These four transcription factors are involved in the multiple cellular pathways, which regulate growth, stress resistance, metabolism, cellular differentiation, and apoptosis in mammals. However, the accurate mode of longevity by FOXO factors is unclear until now. This article describes briefly the existing knowledge that is related to the role of FOXO factors in human longevity.
DOI	10.1155/2017/3494289
关键词[WOS]	EMBRYONIC STEM-CELLS ; HUMAN LONGEVITY ; LIFE-SPAN ; CAENORHABDITIS-ELEGANS ; OXIDATIVE STRESS ; CALORIC RESTRICTION ; PROTEASOME ACTIVITY ; INSULIN-RESISTANCE ; EXTREME LONGEVITY ; SIGNALING PATHWAY
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81522051] ; Beijing Nova Program[XX2013032] ; President's International Fellowship Initiative (PIFI), Chinese Academy of Sciences (CAS), China[2016PT009] ; National Natural Science Foundation of China[81522051] ; Beijing Nova Program[XX2013032] ; President's International Fellowship Initiative (PIFI), Chinese Academy of Sciences (CAS), China[2016PT009]
项目资助者	National Natural Science Foundation of China ; Beijing Nova Program ; President's International Fellowship Initiative (PIFI), Chinese Academy of Sciences (CAS), China
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000407889200001
出版者	HINDAWI LTD
引用统计	被引频次：128[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/28012
专题	离退休人员
通讯作者	Murtaza, Ghulam; Chen, Jianxin
作者单位	1.Beijing Univ Chinese Med, Beisanhuan East Rd, Beijing 100029, Peoples R China 2.COMSATS Inst Informat Technol, Dept Pharm, Abbottabad, Pakistan 3.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 4.COMSATS Inst Informat Technol, Dept Chem, Abbottabad, Pakistan 5.Univ Lahore, Dept Pharm, Lahore, Pakistan 6.Univ Karachi, Fac Pharm & Pharmaceut Sci, Dept Pharmaceut, Karachi, Pakistan
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Murtaza, Ghulam,Khan, Abida Kalsoom,Rashid, Rehana,et al. FOXO Transcriptional Factors and Long-Term Living[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2017:8.
APA	Murtaza, Ghulam,Khan, Abida Kalsoom,Rashid, Rehana,Muneer, Saiqa,Hasan, Syed Muhammad Farid,&Chen, Jianxin.(2017).FOXO Transcriptional Factors and Long-Term Living.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,8.
MLA	Murtaza, Ghulam,et al."FOXO Transcriptional Factors and Long-Term Living".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017):8.