Noninvasive imaging in cancer immunotherapy: The way to precision medicine

doi:10.1016/j.canlet.2019.08.009

	Noninvasive imaging in cancer immunotherapy: The way to precision medicine
	Du, Yang1,2,3 ; Qi, Yafei 4; Jin, Zhengyu 4; Tian, Jie 1,2,4,5,6
发表期刊	CANCER LETTERS
ISSN	0304-3835
	2019
卷号	466 页码:13-22
通讯作者	Jin, Zhengyu(jinzy@pumch.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要	Molecular medicine requires a more precise treatment directed at molecular aberrations detected in tumors on an individual patient level. Immunotherapies empower the body's own immune system to confront tumor cells; however, their efficacy is often affected by tumor heterogeneity. Numerous noninvasive imaging techniques are available to monitor changes in tumor function reflecting therapeutic response, including immunotherapy, and to realize personalized response evaluation. For immunotherapy, strategies for using noninvasive imaging as a prognostic biomarker to identify patients who could benefit from targeted immunotherapy and predict early responders/nonresponders may ultimately lead to improved clinical management, individualized therapy regimens, and better prediction of patient outcomes. Herein, we summarize the recent progress in noninvasive imaging of immunotherapeutic targets such as immune cells, immune checkpoint inhibitors, immune vaccines, and T-cell therapy with chimeric antigen receptor, and review the clinical application of noninvasive imaging in immunotherapy. Finally, we describe the application of multimodal/multispectral imaging and radiomics, which may offer future direction for precision imaging in immunotherapy. With further progress of noninvasive imaging, guiding cancer immunotherapy into the era of precision medicine would be a promising option.
关键词	Precision medicine Cancer Immunotherapy Molecular imaging Immune checkpoint inhibitor
DOI	10.1016/j.canlet.2019.08.009
关键词[WOS]	TUMOR-ASSOCIATED MACROPHAGES ; IMMUNE CHECKPOINT BLOCKADE ; DENDRITIC CELL-MIGRATION ; IN-VIVO TRACKING ; NATURAL-KILLER ; T-CELLS ; SUPPRESSOR-CELLS ; LUNG-CANCER ; ADJUVANT IMMUNOTHERAPY ; MAGNETIC NANOPARTICLES
收录类别	SCI
语种	英语
资助项目	Ministry of Science and Technology of China[2017YFA0205] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[91859119] ; National Public Welfare Basic Scientific Research Program of Chinese Academy of Medical Sciences[2018PT32003] ; National Public Welfare Basic Scientific Research Program of Chinese Academy of Medical Sciences[2017PT32004] ; Ministry of Science and Technology of China[2017YFA0205] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[91859119] ; National Public Welfare Basic Scientific Research Program of Chinese Academy of Medical Sciences[2018PT32003] ; National Public Welfare Basic Scientific Research Program of Chinese Academy of Medical Sciences[2017PT32004]
项目资助者	Ministry of Science and Technology of China ; National Natural Science Foundation of China ; National Public Welfare Basic Scientific Research Program of Chinese Academy of Medical Sciences
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000491622800002
出版者	ELSEVIER IRELAND LTD
七大方向——子方向分类	医学影像处理与分析
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/28899
专题	中国科学院分子影像重点实验室
通讯作者	Jin, Zhengyu; Tian, Jie
作者单位	1.CAS Key Lab Mol Imaging, Stare Key Lab Management & Control Complex Syst, Inst Automat, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 4.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Radiol, 1 Shuaifuyuan, Beijing 100730, Peoples R China 5.Beihang Univ, Sch Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100191, Peoples R China 6.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710126, Shaanxi, Peoples R China
第一作者单位	中国科学院分子影像重点实验室
通讯作者单位	中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Du, Yang,Qi, Yafei,Jin, Zhengyu,et al. Noninvasive imaging in cancer immunotherapy: The way to precision medicine[J]. CANCER LETTERS,2019,466:13-22.
APA	Du, Yang,Qi, Yafei,Jin, Zhengyu,&Tian, Jie.(2019).Noninvasive imaging in cancer immunotherapy: The way to precision medicine.CANCER LETTERS,466,13-22.
MLA	Du, Yang,et al."Noninvasive imaging in cancer immunotherapy: The way to precision medicine".CANCER LETTERS 466(2019):13-22.