CASIA OpenIR
Noninvasive imaging in cancer immunotherapy: The way to precision medicine
Du, Yang1,2,3; Qi, Yafei4; Jin, Zhengyu4; Tian, Jie1,2,4,5,6
Source PublicationCANCER LETTERS
ISSN0304-3835
2019
Volume466Pages:13-22
Corresponding AuthorJin, Zhengyu(jinzy@pumch.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
AbstractMolecular medicine requires a more precise treatment directed at molecular aberrations detected in tumors on an individual patient level. Immunotherapies empower the body's own immune system to confront tumor cells; however, their efficacy is often affected by tumor heterogeneity. Numerous noninvasive imaging techniques are available to monitor changes in tumor function reflecting therapeutic response, including immunotherapy, and to realize personalized response evaluation. For immunotherapy, strategies for using noninvasive imaging as a prognostic biomarker to identify patients who could benefit from targeted immunotherapy and predict early responders/nonresponders may ultimately lead to improved clinical management, individualized therapy regimens, and better prediction of patient outcomes. Herein, we summarize the recent progress in noninvasive imaging of immunotherapeutic targets such as immune cells, immune checkpoint inhibitors, immune vaccines, and T-cell therapy with chimeric antigen receptor, and review the clinical application of noninvasive imaging in immunotherapy. Finally, we describe the application of multimodal/multispectral imaging and radiomics, which may offer future direction for precision imaging in immunotherapy. With further progress of noninvasive imaging, guiding cancer immunotherapy into the era of precision medicine would be a promising option.
KeywordPrecision medicine Cancer Immunotherapy Molecular imaging Immune checkpoint inhibitor
DOI10.1016/j.canlet.2019.08.009
WOS KeywordTUMOR-ASSOCIATED MACROPHAGES ; IMMUNE CHECKPOINT BLOCKADE ; DENDRITIC CELL-MIGRATION ; IN-VIVO TRACKING ; NATURAL-KILLER ; T-CELLS ; SUPPRESSOR-CELLS ; LUNG-CANCER ; ADJUVANT IMMUNOTHERAPY ; MAGNETIC NANOPARTICLES
Indexed BySCI
Language英语
Funding ProjectMinistry of Science and Technology of China[2017YFA0205] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[91859119] ; National Public Welfare Basic Scientific Research Program of Chinese Academy of Medical Sciences[2018PT32003] ; National Public Welfare Basic Scientific Research Program of Chinese Academy of Medical Sciences[2017PT32004] ; Ministry of Science and Technology of China[2017YFA0205] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[91859119] ; National Public Welfare Basic Scientific Research Program of Chinese Academy of Medical Sciences[2018PT32003] ; National Public Welfare Basic Scientific Research Program of Chinese Academy of Medical Sciences[2017PT32004]
Funding OrganizationMinistry of Science and Technology of China ; National Natural Science Foundation of China ; National Public Welfare Basic Scientific Research Program of Chinese Academy of Medical Sciences
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000491622800002
PublisherELSEVIER IRELAND LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/28899
Collection中国科学院自动化研究所
Corresponding AuthorJin, Zhengyu; Tian, Jie
Affiliation1.CAS Key Lab Mol Imaging, Stare Key Lab Management & Control Complex Syst, Inst Automat, Beijing 100190, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
4.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Radiol, 1 Shuaifuyuan, Beijing 100730, Peoples R China
5.Beihang Univ, Sch Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100191, Peoples R China
6.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710126, Shaanxi, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Du, Yang,Qi, Yafei,Jin, Zhengyu,et al. Noninvasive imaging in cancer immunotherapy: The way to precision medicine[J]. CANCER LETTERS,2019,466:13-22.
APA Du, Yang,Qi, Yafei,Jin, Zhengyu,&Tian, Jie.(2019).Noninvasive imaging in cancer immunotherapy: The way to precision medicine.CANCER LETTERS,466,13-22.
MLA Du, Yang,et al."Noninvasive imaging in cancer immunotherapy: The way to precision medicine".CANCER LETTERS 466(2019):13-22.
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