ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment

	ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment
	Zhang, Zhengsheng 1,2,3; Deng, Linglong 1; Bai, Feng 1; Shi, Yongmei 1,2,3; Yu, Hui 1; Yuan, Yonggui 4; Jiang, Tianzi5 ; Jia, Jianping 6; Zhang, Zhijun 1,2,3
发表期刊	BEHAVIOURAL BRAIN RESEARCH
	2011-03-17
卷号	218 期号:1 页码:114-120
文章类型	Article
摘要	To characterize the correlates of cognitive function, serum concentrations of angiotensin converting enzyme (ACE) and brain structure with the ACE insertion or deletion (VD) polymorphism were analyzed in subjects with amnestic-mild cognitive impairment (aMCI). A group of 48 subjects meeting criteria for aMCI and 36 age-matched control subjects were assessed using a comprehensive battery of standardized neuropsychological tests and magnetic resonance imaging (MRI). The ACE gene's I/D polymorphism was analyzed by means of PCR, and serum ACE concentrations were measured using ultraviolet spectrophotometry. Genotype effects on neuropsychological domains and MRI gray matter volume (GMV) measurements (optimized voxel-based morphometry) were examined using general linear models. The D carriers among the aMCI subjects performed significantly worse on AVLT-delayed recall compared to the I homozygous group. The D carriers had higher serum ACE concentrations than did the I homozygous carriers, though this difference only reached statistical significance in the aMCI group. Compared with the I homozygous carriers, in the aMCI group, D carriers showed smaller GMV of the bilateral middle frontal gyrus, right cuneus, right precentral gyrus, right medial frontal gyrus, right superior frontal gyrus, and left postcentral gyrus. However, there was no significant difference in GMV between I homozygous and D carriers in the normal control group. The study suggests that ACE genotype has considerable effect on the cognitive performance of aMCI subjects, particularly episodic memory, serum activity of ACE, and the structure of specified brain regions. The ACE D allele may be a genetic risk factor for greater atrophy of gray matter in aMCI. (C) 2010 Elsevier B.V. All rights reserved.
关键词	Mild Cognitive Impairment Angiotensin Converting Enzyme I/d Polymorphism Cognitive Function Magnetic Resonance Imaging Voxel-based Morphometry
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	ANGIOTENSIN-CONVERTING ENZYME ; INSERTION-DELETION POLYMORPHISM ; VOXEL-BASED MORPHOMETRY ; ALZHEIMERS-DISEASE ; MEMORY IMPAIRMENT ; ENTORHINAL CORTEX ; GENETIC-VARIATION ; BRAIN ATROPHY ; CHINESE-HAN ; HIPPOCAMPUS
收录类别	SCI
语种	英语
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
WOS类目	Behavioral Sciences ; Neurosciences
WOS记录号	WOS:000289137200016
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3100
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Southeast Univ, Sch Clin Med, Nanjing 210009, Peoples R China 2.Nanjing Univ, Affiliated ZhongDa Hosp, Dept Neurol, Nanjing 210009, Peoples R China 3.Southeast Univ, Inst Neuropsychiat Res, Nanjing 210009, Peoples R China 4.Nanjing Med Univ, Affiliated Nanjing Brain Hosp, Dept Psychiat, Nanjing 210029, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China 6.Capital Med Univ, Xuan Wu Hosp, Dept Neurol, Beijing 100053, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zhengsheng,Deng, Linglong,Bai, Feng,et al. ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment[J]. BEHAVIOURAL BRAIN RESEARCH,2011,218(1):114-120.
APA	Zhang, Zhengsheng.,Deng, Linglong.,Bai, Feng.,Shi, Yongmei.,Yu, Hui.,...&Zhang, Zhijun.(2011).ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment.BEHAVIOURAL BRAIN RESEARCH,218(1),114-120.
MLA	Zhang, Zhengsheng,et al."ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment".BEHAVIOURAL BRAIN RESEARCH 218.1(2011):114-120.