Prefrontal-Related Functional Connectivities within the Default Network Are Modulated by COMT val(158)met in Healthy Young Adults

	Prefrontal-Related Functional Connectivities within the Default Network Are Modulated by COMT val(158)met in Healthy Young Adults
	Liu, Bing1 ; Song, Ming1 ; Li, Jun 1; Liu, Yong1 ; Li, Kuncheng 2; Yu, Chunshui 2; Jiang, Tianzi1,3
发表期刊	JOURNAL OF NEUROSCIENCE
	2010-01-06
卷号	30 期号:1 页码:64-69
文章类型	Article
摘要	Previous studies have supported the concept that the default network is an intrinsic brain system that participates in internal modes of cognition. Neural activity and connectivity within the default network, which are correlated with cognitive ability even at rest, may be plausible intermediate phenotypes that will enable us to understand the genetic mechanisms of individuals' cognitive function or the risk for genetic brain diseases. Using resting functional magnetic resonance imaging and imaging genetic paradigms, we investigated whether individual default network connectivity was modulated by COMT val(158)met in 57 healthy young subjects. Compared with COMT heterozygous individuals, homozygous val individuals showed significantly decreased prefrontal-related connectivities, which primarily occurred between prefrontal regions and the posterior cingulate/restrosplenial cortices. Further analyses of the topological characteristics of the default network showed homozygous val individuals had significantly fewer node degrees in the prefrontal regions. This finding may partially elucidate previous reports that the COMT val variant is associated with inefficient prefrontal information processing and poor cognitive performance. Our findings suggest that default network connectivity that involves the prefrontal cortex is modulated by COMT val(158)met through differential effects on prefrontal dopamine levels.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	CATECHOL-O-METHYLTRANSFERASE ; WORKING-MEMORY ; BRAIN ACTIVITY ; SCHIZOPHRENIA ; POLYMORPHISM ; EXPRESSION ; DOPAMINE ; GENOTYPE ; ARCHITECTURE ; ASSOCIATION
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000273347300007
引用统计	被引频次：79[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3131
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China 2.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Liu, Bing,Song, Ming,Li, Jun,et al. Prefrontal-Related Functional Connectivities within the Default Network Are Modulated by COMT val(158)met in Healthy Young Adults[J]. JOURNAL OF NEUROSCIENCE,2010,30(1):64-69.
APA	Liu, Bing.,Song, Ming.,Li, Jun.,Liu, Yong.,Li, Kuncheng.,...&Jiang, Tianzi.(2010).Prefrontal-Related Functional Connectivities within the Default Network Are Modulated by COMT val(158)met in Healthy Young Adults.JOURNAL OF NEUROSCIENCE,30(1),64-69.
MLA	Liu, Bing,et al."Prefrontal-Related Functional Connectivities within the Default Network Are Modulated by COMT val(158)met in Healthy Young Adults".JOURNAL OF NEUROSCIENCE 30.1(2010):64-69.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Liu-2010-Prefrontal-（696KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载