Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI

	Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI
	Skup, Martha 3; Zhu, Hongtu 1,2; Wang, Yaping 1,2,4; Giovanello, Kelly S.2,5; Lin, Ja-an 1; Shen, Dinggang 2,6; Shi, Feng 2,6; Gao, Wei 7; Lin, Weili 2,6; Fan, Yong 8; Zhang, Heping3 ; Alzheimer's Dis Neuroimaging Initi
发表期刊	NEUROIMAGE
	2011-06-01
卷号	56 期号:3 页码:890-906
文章类型	Article
摘要	We used longitudinal magnetic resonance imaging (MRI) data to determine whether there are any gender differences in grey matter atrophy patterns over time in 197 individuals with probable Alzheimer's disease (AD) and 266 with amnestic mild cognitive impairment (aMCI), compared with 224 healthy controls participating in the Alzheimer's Disease Neuroimaging Initiative (ADNI). While previous research has differentiated probable AD and aMCI groups from controls in brain atrophy, it is unclear whether and how sex plays a role in patterns of change over time. Using regional volumetric maps, we fit longitudinal models to the grey matter data collected at repeated occasions, seeking differences in patterns of volume change over time by sex and diagnostic group in a voxel-wise analysis. Additionally, using a region-of-interest approach, we fit longitudinal models to the global volumetric data of predetermined brain regions to determine whether this more conventional approach is sufficient for determining sex and group differences in atrophy. Our longitudinal analyses revealed that, of the various grey matter regions investigated. males and females in the AD group and the aMCI group showed different patterns of decline over time compared to controls in the bilateral precuneus, bilateral caudate nucleus, right entorhinal gyrus, bilateral thalamus, bilateral middle temporal gyrus, left insula, and right amygdala. As one of the first investigation to model more than two time points of structural MRI data over time. our findings add insight into how AD and aMCI males and females differ from controls and from each other over time. (C) 2011 Elsevier Inc. All rights reserved.
关键词	Alzheimer's Disease Mild Cognitive Impairment Sex Differences Longitudinal Mri Gee
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	MILD COGNITIVE IMPAIRMENT ; VOXEL-BASED MORPHOMETRY ; QUANTITATIVE VOLUMETRIC-ANALYSIS ; NONSPATIAL WORKING-MEMORY ; MEDIAL TEMPORAL ATROPHY ; MINI-MENTAL STATE ; ADULT HUMAN BRAIN ; ALZHEIMERS-DISEASE ; GENDER-DIFFERENCES ; GRAY-MATTER
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000290649300006
引用统计	被引频次：72[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3138
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Univ N Carolina, Sch Publ Hlth, Dept Biostat, Chapel Hill, NC 27599 USA 2.Univ N Carolina, Biomed Res Imaging Ctr, Chapel Hill, NC 27599 USA 3.Yale Univ, Sch Publ Hlth, Div Biostat, New Haven, CT 06520 USA 4.NW Polytech Univ, Dept Automat, Xian 710072, Shaanxi Prov, Peoples R China 5.Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA 6.Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA 7.Univ N Carolina, Dept Biomed Engn, Chapel Hill, NC 27599 USA 8.Chinese Acad Sci, Inst Automat, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Skup, Martha,Zhu, Hongtu,Wang, Yaping,et al. Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI[J]. NEUROIMAGE,2011,56(3):890-906.
APA	Skup, Martha.,Zhu, Hongtu.,Wang, Yaping.,Giovanello, Kelly S..,Lin, Ja-an.,...&Alzheimer's Dis Neuroimaging Initi.(2011).Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI.NEUROIMAGE,56(3),890-906.
MLA	Skup, Martha,et al."Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI".NEUROIMAGE 56.3(2011):890-906.