Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia

	Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia
	Wang, Kun 2; van Meer, Maurits P. A.1; van der Marel, Kajo 1; van der Toorn, Annette 1; Xu, Lijuan 2; Liu, Yingjun 2; Viergever, Max A.1; Jiang, Tianzi2 ; Dijkhuizen, Rick M.1
发表期刊	NMR IN BIOMEDICINE
	2011
卷号	24 期号:1 页码:61-67
文章类型	Article
摘要	Spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) MRI signal during the resting state are increasingly being studied in healthy and diseased brain in humans and animal models. Yet, the relationship between functional brain status and the characteristics of spontaneous BOLD fluctuations remains poorly understood. In order to obtain more insights into this relationship and, in particular, the effects of anesthesia thereupon, we investigated the spatial and temporal correlations of spontaneous BOLD fluctuations in somatosensory and motor regions of rat brain at different inhalation levels of the frequently applied anesthetic isoflurane. We found that the temporal scaling, characterized by the Hurst exponent (H), showed persistent behavior (H > 0.5) at 0.5-1.0% isoflurane. Furthermore, low-pass-filtered spontaneous BOLD oscillations were correlated significantly in bilateral somatosensory and bilateral motor cortices, reflective of interhemispheric functional connectivity. Under 2.9% isoflurane anesthesia, the temporal scaling characteristics approached those of Gaussian white noise (H = 0.5), the relative amplitude of BOLD low-frequency fluctuations declined, and cross-correlations of these oscillations between functionally connected regions decreased significantly. Loss of interhemispheric functional connectivity at 2.9% isoflurane anesthesia was stronger between bilateral motor regions than between bilateral somatosensory regions, which points to distinct effects of anesthesia on differentially organized neuronal networks. Although we cannot completely rule out a possible contribution from hemodynamic signals with a non-neuronal origin, our results emphasize that spatiotemporal characteristics of spontaneous BOLD fluctuations are related to the brain's specific functional status and network organization, and demonstrate that these are largely preserved under light to mild anesthesia with isoflurane. Copyright (C) 2010 John Wiley & Sons, Ltd.
关键词	Bold Signal Resting State Functional Mri Isoflurane Anesthesia Rat Brain Functional Connectivity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Technology
关键词[WOS]	FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; SEVOFLURANE ANESTHESIA ; GLUCOSE-UTILIZATION ; FMRI ; MRI ; ARCHITECTURE ; HALOTHANE ; DYNAMICS ; WAVELETS
收录类别	SCI
语种	英语
WOS研究方向	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS类目	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS记录号	WOS:000287110300007
引用统计	被引频次：54[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3140
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Univ Med Ctr Utrecht, Image Sci Inst, Biomed MR Imaging & Spect Grp, NL-3508 GA Utrecht, Netherlands 2.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing, Peoples R China
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Wang, Kun,van Meer, Maurits P. A.,van der Marel, Kajo,et al. Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia[J]. NMR IN BIOMEDICINE,2011,24(1):61-67.
APA	Wang, Kun.,van Meer, Maurits P. A..,van der Marel, Kajo.,van der Toorn, Annette.,Xu, Lijuan.,...&Dijkhuizen, Rick M..(2011).Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia.NMR IN BIOMEDICINE,24(1),61-67.
MLA	Wang, Kun,et al."Temporal scaling properties and spatial synchronization of spontaneous blood oxygenation level-dependent (BOLD) signal fluctuations in rat sensorimotor network at different levels of isoflurane anesthesia".NMR IN BIOMEDICINE 24.1(2011):61-67.