Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects

	Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects
	Wang, Junping 1; Qin, Wen 1; Liu, Bing2 ; Wang, Dawei 1; Zhang, Yunting 1; Jiang, Tianzi2 ; Yu, Chunshui 1
发表期刊	NEUROIMAGE
	2013-11-01
卷号	81 页码:199-204
文章类型	Article
摘要	The oxytocin receptor gene (OXTR) rs53576A has been associated with autism spectrum disorders (ASDs). A smaller hypothalamic volume has been reported in healthy male A-allele carriers than in male GG homozygotes and in patients with ASDs than in healthy controls. These findings prompt the hypothesis that male AA homozygotes may have weaker hypothalamic functional connectivity when compared to male G-allele carriers. We calculated local functional connectivity density (FCD) using a voxel-wise data-driven approach based on resting-state functional MRI data in 270 young healthy subjects. Both the main effect of genotype and the gender-by-genotype interaction were considered. Of the whole brain, only the local FCD of the hypothalamus exhibited the main effect of genotype. Post-hoc testing revealed significantly lower local FCD in male AA homozygotes compared to male G-allele carriers although there was only a trend of significance in the gender-by-genotype interaction. We further analyzed the resting-state functional connectivity (rsFC) of the hypothalamic region that demonstrating significant genotype differences in local FCD. We found a significant gender-by-genotype interaction in rsFC between the hypothalamic region and the left dorsolateral prefrontal cortex, but no significant main effect of genotype was found. Post-hoc testing revealed that this rsFC was significantly weaker in male AA homozygotes compared to male G-allele carriers. Our findings identify gender-dependent mechanisms of OXTR rs53576 gene variation impacting the functional connectivity of the hypothalamus in healthy individuals and suggest that these mechanisms are important for understanding ASDs. (C) 2013 Elsevier Inc. All rights reserved.
关键词	Oxytocin Receptor Single Nucleotide Polymorphism Autism Hypothalamus Functional Connectivity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	AUTISM SPECTRUM DISORDERS ; OXYTOCIN RECEPTOR OXTR ; VASOPRESSIN ; MRI ; THERAPEUTICS ; ASSOCIATION ; POPULATION ; BEHAVIOR ; MATTER ; MEMORY
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000322934400019
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3158
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Junping,Qin, Wen,Liu, Bing,et al. Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects[J]. NEUROIMAGE,2013,81:199-204.
APA	Wang, Junping.,Qin, Wen.,Liu, Bing.,Wang, Dawei.,Zhang, Yunting.,...&Yu, Chunshui.(2013).Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects.NEUROIMAGE,81,199-204.
MLA	Wang, Junping,et al."Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects".NEUROIMAGE 81(2013):199-204.