| KIBRA gene variants are associated with synchronization within the default-mode and executive control networks | |
Wang, Dawei1; Liu, Bing2 ; Qin, Wen1; Wang, Junping1; Zhang, Yunting1; Jiang, Tianzi2; Yu, Chunshui1,3
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| 发表期刊 | NEUROIMAGE
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| 2013-04-01 | |
| 卷号 | 69页码:213-222 |
| 文章类型 | Article |
| 摘要 | Genetic variation at the KIBRA rs17070145 polymorphism has been linked to episodic memory, executive function, and Alzheimer's disease (AD), which are related to the structural and functional integrity of the default-mode network (DMN) and executive control network (ECN). We hypothesize that the KIBRA polymorphism could modulate the structure and function of the DMN and ECN in healthy young subjects, which might underlie the association between this gene and cognitive function. To test our hypothesis, we analyzed the resting-state synchronization in the DMN and ECN in 288 young, healthy Chinese Han subjects. We found that carriers of the KIBRA C-allele demonstrated an increased synchronization in the posterior cingulate cortex (PCC) and medial prefrontal cortex (MPFC) of the DMN and in the right anterior insula, bilateral caudate nuclei, and bilateral dorsal anterior cingulate cortices (dACC) of the ECN compared to individuals with a TT genotype. Moreover, KIBRA C-allele carriers also showed a smaller gray matter volume (GMV) in the MPFC and bilateral dACCs than TT individuals. In contrast, there were no significant genotype differences in the synchronization of either the visual network or the sensorimotor network. These findings suggest that the polymorphism in the KIBRA gene affects GMV and the function of the DMN and ECN. This increased synchronization is likely a reflection of compensation for the regional gray matter deficits in these networks in young healthy subjects. The association between KIBRA polymorphisms and the DMN and ECN should be further explored in a healthy older population and in patients with AD. (C) 2013 Elsevier Inc. All rights reserved. |
| 关键词 | Kibra Episodic Memory Executive Function Resting State Network Mri |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 关键词[WOS] | ANTERIOR CINGULATE CORTEX ; RESTING-STATE NETWORKS ; INDEPENDENT COMPONENT ANALYSIS ; INFLUENCES EPISODIC MEMORY ; ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; MATTER HYPOMETABOLISM ; FMRI ; PERFORMANCE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS记录号 | WOS:000314627800020 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/3163 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 作者单位 | 1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 3.Tianjin Med Univ, Sch Med Imaging, Tianjin 300052, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Dawei,Liu, Bing,Qin, Wen,et al. KIBRA gene variants are associated with synchronization within the default-mode and executive control networks[J]. NEUROIMAGE,2013,69:213-222. |
| APA | Wang, Dawei.,Liu, Bing.,Qin, Wen.,Wang, Junping.,Zhang, Yunting.,...&Yu, Chunshui.(2013).KIBRA gene variants are associated with synchronization within the default-mode and executive control networks.NEUROIMAGE,69,213-222. |
| MLA | Wang, Dawei,et al."KIBRA gene variants are associated with synchronization within the default-mode and executive control networks".NEUROIMAGE 69(2013):213-222. |
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| Wang-2013-KIBRA gene（988KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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