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KIBRA gene variants are associated with synchronization within the default-mode and executive control networks
Wang, Dawei1; Liu, Bing2; Qin, Wen1; Wang, Junping1; Zhang, Yunting1; Jiang, Tianzi2; Yu, Chunshui1,3
Source PublicationNEUROIMAGE
2013-04-01
Volume69Pages:213-222
SubtypeArticle
AbstractGenetic variation at the KIBRA rs17070145 polymorphism has been linked to episodic memory, executive function, and Alzheimer's disease (AD), which are related to the structural and functional integrity of the default-mode network (DMN) and executive control network (ECN). We hypothesize that the KIBRA polymorphism could modulate the structure and function of the DMN and ECN in healthy young subjects, which might underlie the association between this gene and cognitive function. To test our hypothesis, we analyzed the resting-state synchronization in the DMN and ECN in 288 young, healthy Chinese Han subjects. We found that carriers of the KIBRA C-allele demonstrated an increased synchronization in the posterior cingulate cortex (PCC) and medial prefrontal cortex (MPFC) of the DMN and in the right anterior insula, bilateral caudate nuclei, and bilateral dorsal anterior cingulate cortices (dACC) of the ECN compared to individuals with a TT genotype. Moreover, KIBRA C-allele carriers also showed a smaller gray matter volume (GMV) in the MPFC and bilateral dACCs than TT individuals. In contrast, there were no significant genotype differences in the synchronization of either the visual network or the sensorimotor network. These findings suggest that the polymorphism in the KIBRA gene affects GMV and the function of the DMN and ECN. This increased synchronization is likely a reflection of compensation for the regional gray matter deficits in these networks in young healthy subjects. The association between KIBRA polymorphisms and the DMN and ECN should be further explored in a healthy older population and in patients with AD. (C) 2013 Elsevier Inc. All rights reserved.
KeywordKibra Episodic Memory Executive Function Resting State Network Mri
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordANTERIOR CINGULATE CORTEX ; RESTING-STATE NETWORKS ; INDEPENDENT COMPONENT ANALYSIS ; INFLUENCES EPISODIC MEMORY ; ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; MATTER HYPOMETABOLISM ; FMRI ; PERFORMANCE
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000314627800020
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3163
Collection脑网络组研究中心
Affiliation1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
2.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China
3.Tianjin Med Univ, Sch Med Imaging, Tianjin 300052, Peoples R China
Recommended Citation
GB/T 7714
Wang, Dawei,Liu, Bing,Qin, Wen,et al. KIBRA gene variants are associated with synchronization within the default-mode and executive control networks[J]. NEUROIMAGE,2013,69:213-222.
APA Wang, Dawei.,Liu, Bing.,Qin, Wen.,Wang, Junping.,Zhang, Yunting.,...&Yu, Chunshui.(2013).KIBRA gene variants are associated with synchronization within the default-mode and executive control networks.NEUROIMAGE,69,213-222.
MLA Wang, Dawei,et al."KIBRA gene variants are associated with synchronization within the default-mode and executive control networks".NEUROIMAGE 69(2013):213-222.
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