| A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network | |
Long, Haixia1,2; Liu, Bing1,2 ; Hou, Bing1,2; Wang, Chao3; Kendrick, Keith M.3; Yu, Chunshui4; Jiang, Tianzi1,2,3,5
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| 发表期刊 | CHINESE SCIENCE BULLETIN
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| 2014-05-01 | |
| 卷号 | 59期号:13页码:1355-1361 |
| 文章类型 | Article |
| 摘要 | The serotonin-transporter-linked polymorphic region (5-HTTLPR) is associated with mood disorders. This association is thought to be due to amygdala hyperresponsiveness to negative emotional stimuli as a result of reduced frontal cortical control. In Caucasians, the short form is associated with this effect, but in Han Chinese we recently found that the long form is involved. Serotonin receptors have rich expression in default mode network (DMN) regions and the recent studies have found an association between the short form of the 5-HTTLPR and DMN functional connectivity (FC) in Caucasians. The present study has investigated whether there may also be an ethnic difference in this influence of 5-HTTLPR on the DMN. We recruited 233 young Han Chinese subjects and calculated the resting-state default-network FC. Our study found that the L carriers had decreased FC in the bilateral medial prefrontal cortex, right parahippocampal gyrus, left middle temporal gyrus, and increased FC in left precuneus (Pcu) compared to SS. The PCC-Pcu FC in L carriers was significantly negatively correlated with the depression scores. Our findings, therefore, suggest that there is also a difference between Caucasian and Han Chinese subjects in the association between the different forms of the 5-HTTLPR and DMN functional connectivity. |
| 关键词 | 5-httlpr Default Mode Network Ethnic Difference Resting-state Functional Connectivity |
| WOS标题词 | Science & Technology |
| 关键词[WOS] | SEROTONIN TRANSPORTER GENE ; MAJOR DEPRESSIVE DISORDER ; ANXIETY-RELATED TRAITS ; FUNCTIONAL CONNECTIVITY ; ANTIDEPRESSANT RESPONSE ; REGULATORY REGION ; CINGULATE CORTEX ; HUMAN AMYGDALA ; STATE ; 1ST-EPISODE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000333613100002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/3192 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 4.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia |
| 第一作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Long, Haixia,Liu, Bing,Hou, Bing,et al. A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network[J]. CHINESE SCIENCE BULLETIN,2014,59(13):1355-1361. |
| APA | Long, Haixia.,Liu, Bing.,Hou, Bing.,Wang, Chao.,Kendrick, Keith M..,...&Jiang, Tianzi.(2014).A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network.CHINESE SCIENCE BULLETIN,59(13),1355-1361. |
| MLA | Long, Haixia,et al."A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network".CHINESE SCIENCE BULLETIN 59.13(2014):1355-1361. |
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