Genome-Wide Analysis of Human SNPs at Long Intergenic Noncoding RNAs

	Genome-Wide Analysis of Human SNPs at Long Intergenic Noncoding RNAs
	Chen, Geng 1; Qiu, Chengxiang1,2 ; Zhang, Qipeng 1; Liu, Bing2 ; Cui, Qinghua 1,3,4
发表期刊	HUMAN MUTATION
	2013-02-01
卷号	34 期号:2 页码:338-344
文章类型	Article
摘要	Long intergenic noncoding RNAs (lincRNAs) represent a large portion of the noncoding genes in mammals and other eukaryotes but remains among the least well-understood of genetic factors to date. Here, we systematically analyzed the human SNPs of lincRNAs at a genome level. We found a significantly lower SNP density in lincRNA regions than both their upstream and downstream flanking regions. Functional regions show lower SNP density than other regions in lincRNAs. We revealed that lincRNAs with higher expression levels and broader expression spectrum have significantly lower SNP density. Moreover, we identified lincRNAs that are under recent positive selection and revealed that these lincRNAs show distinct SNP density, expression level, and tissue specificity. Importantly, we identified a genetic variant (rs7990916:T>C) under recent positive selection at a brain-specific lincRNA that significantly affects the structure of normal brain. Analysis of brain magnetic resonance images showed that individuals with CC genotype have significant bigger regional gray matter volume than individuals with TT genotype. Moreover, the genotype of this SNP shows different distribution in normal elders, mild cognitive impairment, and Alzheimer disease subjects, suggesting that this lincRNA may have a role in physiology and pathophysiology of human brain.
关键词	Long Intergenic Noncoding Rna Snp Alzheimer Disease Brain
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	MICRORNA TARGET SITES ; BIRTH-WEIGHT ; POLYMORPHISMS ; GENES ; IDENTIFICATION ; DATABASE ; H19 ; ASSOCIATION ; CANCER ; RISK
收录类别	SCI
语种	英语
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000314477700011
引用统计	被引频次：46[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3205
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Peking Univ, Sch Basic Med Sci, Dept Biomed Informat, Beijing 100191, Peoples R China 2.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 3.Peking Univ, Inst Syst Biomed, Beijing 100191, Peoples R China 4.Peking Univ, MOE Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Chen, Geng,Qiu, Chengxiang,Zhang, Qipeng,et al. Genome-Wide Analysis of Human SNPs at Long Intergenic Noncoding RNAs[J]. HUMAN MUTATION,2013,34(2):338-344.
APA	Chen, Geng,Qiu, Chengxiang,Zhang, Qipeng,Liu, Bing,&Cui, Qinghua.(2013).Genome-Wide Analysis of Human SNPs at Long Intergenic Noncoding RNAs.HUMAN MUTATION,34(2),338-344.
MLA	Chen, Geng,et al."Genome-Wide Analysis of Human SNPs at Long Intergenic Noncoding RNAs".HUMAN MUTATION 34.2(2013):338-344.

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