Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Noninvasive Imaging for Assessment of the Efficacy of Therapeutic Agents for Hepatocellular Carcinoma | |
Liang, Qian1,2,3![]() ![]() ![]() | |
发表期刊 | Molecular Imaging and Biology
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ISSN | 1536-1632 |
2019-12 | |
期号 | 10.1007/s11307-019-01431-5页码:1-14 |
通讯作者 | Zhu, Xu(drzhuxu@163.com) ; Du, Yang(yang.du@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) |
文章类型 | Article |
摘要 | Morphological imaging techniques are typically used in the anti-cancer drug efficacy evaluation process. However, these techniques can evaluate the therapeutic efficacy only when the tumor shows anatomic changes—usually at later stages, when the therapeutic effects are poor. In contrast, molecular imaging allows noninvasive monitoring of tumor growth, assessment of drug metabolism, and evaluation of therapeutic efficacy at the molecular and cellular levels. Multimodality molecular imaging, which combines the advantages of various imaging modalities, provides even more comprehensive therapeutic efficacy assessment in preclinical and clinical studies. This review provides an overview of molecular imaging evaluation of therapeutic efficacy of the anti-tumor drugs in hepatocellular carcinoma (HCC) both in preclinical and clinical research, which holds great promise in guiding HCC treatment into the era of precision medicine. |
关键词 | Hepatocellular carcinoma Molecular imaging Preclinical drug evaluation Clinical trial Therapeutics |
DOI | 10.1007/s11307-019-01431-5 |
关键词[WOS] | CONTRAST-ENHANCED CT ; IN-VIVO ; TRANSARTERIAL CHEMOEMBOLIZATION ; QUANTITATIVE ASSESSMENT ; TUMOR RESPONSE ; SORAFENIB ; DOXORUBICIN ; MODEL ; MRI ; COMBINATION |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Ministry of Science and Technology of China[2017YFA0205] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[91859119] ; National Public Welfare Basic Scientific Research Program of the Chinese Academy of Medical Sciences[2018PT32003] ; National Public Welfare Basic Scientific Research Program of the Chinese Academy of Medical Sciences[2017PT32004] |
项目资助者 | Ministry of Science and Technology of China ; National Natural Science Foundation of China ; National Public Welfare Basic Scientific Research Program of the Chinese Academy of Medical Sciences |
WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000575628700001 |
出版者 | SPRINGER |
七大方向——子方向分类 | 医学影像处理与分析 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/39020 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Zhu, Xu; Du, Yang; Tian, Jie |
作者单位 | 1.中国科学院自动化研究所 2.中国科学院大学 3.分子影像重点实验室 4.癌症和转化医学介入治疗重点实验室 5.北航大数据精准医疗创新研究中心 6.教育部分子和神经影像工程研究中心 |
第一作者单位 | 中国科学院自动化研究所 |
通讯作者单位 | 中国科学院自动化研究所 |
推荐引用方式 GB/T 7714 | Liang, Qian,Kong, Lingxin,Zhu, Xu,et al. Noninvasive Imaging for Assessment of the Efficacy of Therapeutic Agents for Hepatocellular Carcinoma[J]. Molecular Imaging and Biology,2019(10.1007/s11307-019-01431-5):1-14. |
APA | Liang, Qian,Kong, Lingxin,Zhu, Xu,Du, Yang,&Tian, Jie.(2019).Noninvasive Imaging for Assessment of the Efficacy of Therapeutic Agents for Hepatocellular Carcinoma.Molecular Imaging and Biology(10.1007/s11307-019-01431-5),1-14. |
MLA | Liang, Qian,et al."Noninvasive Imaging for Assessment of the Efficacy of Therapeutic Agents for Hepatocellular Carcinoma".Molecular Imaging and Biology .10.1007/s11307-019-01431-5(2019):1-14. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
10.1007@s11307-019-0(3951KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
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