Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models

	Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models
	Liu, Kai 1; Lu, Yujie 2; Tian, Jie 1,3; Qin, Chenghu 1; Yang, Xin1 ; Zhu, Shouping 3; Yang, Xiang1,3 ; Gao, Quansheng 4; Han, Dong 1
发表期刊	OPTICS EXPRESS
	2010-09-27
卷号	18 期号:20 页码:20988-21002
文章类型	Article
摘要	In vivo bioluminescence imaging (BLI) has played a more and more important role in biomedical research of small animals. Bioluminescence tomography (BLT) further translates the BLI optical information into three-dimensional bioluminescent source distribution, which could greatly facilitate applications in related studies. Although the diffusion approximation (DA) is one of the most widely-used forward models, higher-order approximations are still needed for in vivo small animal imaging. In this work, as a higher-order approximation theory, the performance of the simplified spherical harmonics approximation (SPN) in BLT is evaluated thoroughly on heterogeneous mouse models. In the numerical validations, the SPN based results demonstrate better imaging quality compared with diffusion approximation heterogeneously under various source locations over wide optical domain. In what follows, heterogeneous experimental BLT reconstructions using in vivo mouse further evaluate the capability of the higher-order method for practical biomedical applications. (C) 2010 Optical Society of America
关键词	Tomography Inverse Problem Light Propagation Spectroscopy Fluorescence Luminescence
WOS标题词	Science & Technology ; Physical Sciences
关键词[WOS]	DIFFUSE OPTICAL TOMOGRAPHY ; IMAGE-RECONSTRUCTION ; BIOLOGICAL TISSUE ; RADIATIVE-TRANSFER ; PHOTON MIGRATION ; LIGHT TRANSPORT ; SIMULATION ; EQUATIONS ; FEASIBILITY ; SYSTEM
收录类别	SCI
语种	英语
WOS研究方向	Optics
WOS类目	Optics
WOS记录号	WOS:000283679200045
引用统计	被引频次：56[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3933
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100190, Peoples R China 2.Univ Calif Los Angeles, David Geffen Sch Med, Crump Inst Mol Imaging, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA 3.Xidian Univ, Sch Life Sci & Technol, Life Sci Ctr, Xian 710071, Shaanxi, Peoples R China 4.Acad Mil Med Sci, Lab Anim Ctr, Beijing 100850, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Liu, Kai,Lu, Yujie,Tian, Jie,et al. Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models[J]. OPTICS EXPRESS,2010,18(20):20988-21002.
APA	Liu, Kai.,Lu, Yujie.,Tian, Jie.,Qin, Chenghu.,Yang, Xin.,...&Han, Dong.(2010).Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models.OPTICS EXPRESS,18(20),20988-21002.
MLA	Liu, Kai,et al."Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models".OPTICS EXPRESS 18.20(2010):20988-21002.

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