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Food Addiction and Neuroimaging
Zhang, Yi1,2; von Deneen, Karen M.1,2; Tian, Jie2,3; Gold, Mark S.1; Liu, Yijun1
发表期刊CURRENT PHARMACEUTICAL DESIGN
2011-04-01
卷号17期号:12页码:1149-1157
文章类型Review
摘要Obesity has become a serious epidemic and one of the leading global health problems. However, much of the current debate has been fractious, and etiologies of obesity have been attributed to eating behavior (i.e. fast food consumption), personality, depression, addiction or genetics. One of the interesting new hypotheses for explaining the development of obesity involves a food addiction model, which suggests that food is not eaten as much for survival as pleasure and that hedonic overeating is relevant to both substance-related disorders and eating disorders. Accumulating evidence has shown that there are a number of shared neural and hormonal pathways as well as distinct differences in these pathways that may help researchers discover why certain individuals continue to overeat despite health and other consequences, and becomes more and more obese. Functional neuroimaging studies have further revealed that pleasant smelling, looking, and tasting food has reinforcing characteristics similar to drugs of abuse. Many of the brain changes reported for hedonic eating and obesity are also seen in various types of addictions. Most importantly, overeating and obesity may have an acquired drive similar to drug addiction with respect to motivation and incentive craving. In both cases, the desire and continued satisfaction occur after early and repeated exposure to stimuli. The acquired drive for eating food and relative weakness of the satiety signal would cause an imbalance between the drive and hunger/reward centers in the brain and their regulation. In the current paper, we first provide a summary of literature on food addition from eight different perspectives, and then we proposed a research paradigm that may allow screening of new pharmacological treatment on the basis of functional magnetic resonance imaging (fMRI).
关键词Obesity Overeating Dopamine Food Addiction Pharmacological Treatment Development Reinforcement Neuroimaging
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]PRADER-WILLI-SYNDROME ; ORBITOFRONTAL CORTEX ; BRAIN DOPAMINE ; HUMAN AMYGDALA ; APPETITIVE BEHAVIOR ; METABOLIC SYNDROME ; ANGELMAN-SYNDROMES ; FEEDING-BEHAVIOR ; DORSAL STRIATUM ; DRUG-ADDICTION
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Pharmacology & Pharmacy
WOS记录号WOS:000290950800007
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/3940
专题中国科学院分子影像重点实验室
通讯作者Liu, Yijun
作者单位1.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32610 USA
2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
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GB/T 7714
Zhang, Yi,von Deneen, Karen M.,Tian, Jie,et al. Food Addiction and Neuroimaging[J]. CURRENT PHARMACEUTICAL DESIGN,2011,17(12):1149-1157.
APA Zhang, Yi,von Deneen, Karen M.,Tian, Jie,Gold, Mark S.,&Liu, Yijun.(2011).Food Addiction and Neuroimaging.CURRENT PHARMACEUTICAL DESIGN,17(12),1149-1157.
MLA Zhang, Yi,et al."Food Addiction and Neuroimaging".CURRENT PHARMACEUTICAL DESIGN 17.12(2011):1149-1157.
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