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Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals
Yuan, Kai2; Qin, Wei2; Dong, Minghao2; Liu, Jixin2; Sun, Jinbo2; Liu, Peng2; Zhang, Yi2; Wang, Wei3; Wang, Yarong3; Li, Qiang3; Zhao, Liyan4; von Deneen, Karen M.5,6; Liu, Yijun5,6; Gold, Mark S.5,6; Tian, Jie1,2
AbstractPrevious neuroimaging studies have demonstrated both structural and functional damages in heroin-dependent individuals. However, few studies investigated gray matter deficits and abnormal resting-state networks together in heroin-dependent individuals. In the present study, voxel-based morphometry (VBM) was used to identify brain regions with gray matter density reduction. Resting-state fMRI connectivity analysis was employed to assess potential functional abnormalities during resting-state. All clinical significances were investigated by examining their association with duration of heroin use. Compared with healthy subjects, heroin-dependent individuals showed significant reduction in gray matter density in the right dorsolateral prefrontal cortex (DLPFC) and a decrease in resting-state functional connectivity between the right DLPFC and left inferior parietal lobe (IPL). The gray matter density of the right DLPFC and its resting-state functional connectivity with the left IPL both showed significantly negative correlation with duration of heroin use, which were likely to be related to the functional impairments in decision-making and cognitive control exhibited by heroin-dependent individuals. Our findings demonstrated that long heroin dependence impairs the right DLPFC in heroin-dependent individuals, including structural deficits and resting-state functional impairments. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
KeywordHeroin Voxel-based Morphometry Resting-state
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000281473000005
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Cited Times:63[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorTian, Jie
Affiliation1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Peoples R China
3.Fourth Mil Med Univ, Xian 710038, Shaanxi, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
5.Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL 32610 USA
6.Univ Florida, McKnight Brain Inst, Dept Neurosci, Gainesville, FL 32610 USA
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yuan, Kai,Qin, Wei,Dong, Minghao,et al. Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals[J]. NEUROSCIENCE LETTERS,2010,482(2):101-105.
APA Yuan, Kai.,Qin, Wei.,Dong, Minghao.,Liu, Jixin.,Sun, Jinbo.,...&Tian, Jie.(2010).Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals.NEUROSCIENCE LETTERS,482(2),101-105.
MLA Yuan, Kai,et al."Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals".NEUROSCIENCE LETTERS 482.2(2010):101-105.
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