Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals | |
Yuan, Kai2; Qin, Wei2; Dong, Minghao2; Liu, Jixin2; Sun, Jinbo2; Liu, Peng2; Zhang, Yi2; Wang, Wei3; Wang, Yarong3; Li, Qiang3![]() | |
发表期刊 | NEUROSCIENCE LETTERS
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2010-09-27 | |
卷号 | 482期号:2页码:101-105 |
文章类型 | Article |
摘要 | Previous neuroimaging studies have demonstrated both structural and functional damages in heroin-dependent individuals. However, few studies investigated gray matter deficits and abnormal resting-state networks together in heroin-dependent individuals. In the present study, voxel-based morphometry (VBM) was used to identify brain regions with gray matter density reduction. Resting-state fMRI connectivity analysis was employed to assess potential functional abnormalities during resting-state. All clinical significances were investigated by examining their association with duration of heroin use. Compared with healthy subjects, heroin-dependent individuals showed significant reduction in gray matter density in the right dorsolateral prefrontal cortex (DLPFC) and a decrease in resting-state functional connectivity between the right DLPFC and left inferior parietal lobe (IPL). The gray matter density of the right DLPFC and its resting-state functional connectivity with the left IPL both showed significantly negative correlation with duration of heroin use, which were likely to be related to the functional impairments in decision-making and cognitive control exhibited by heroin-dependent individuals. Our findings demonstrated that long heroin dependence impairs the right DLPFC in heroin-dependent individuals, including structural deficits and resting-state functional impairments. (C) 2010 Elsevier Ireland Ltd. All rights reserved. |
关键词 | Heroin Voxel-based Morphometry Resting-state |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
关键词[WOS] | VOXEL-BASED MORPHOMETRY ; FUNCTIONAL CONNECTIVITY ; PREFRONTAL CORTEX ; OPIATE DEPENDENCE ; DEFAULT MODE ; FMRI ; BRAIN ; CUES ; NETWORKS ; COCAINE |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000281473000005 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/3946 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Tian, Jie |
作者单位 | 1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Peoples R China 3.Fourth Mil Med Univ, Xian 710038, Shaanxi, Peoples R China 4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China 5.Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL 32610 USA 6.Univ Florida, McKnight Brain Inst, Dept Neurosci, Gainesville, FL 32610 USA |
通讯作者单位 | 中国科学院自动化研究所 |
推荐引用方式 GB/T 7714 | Yuan, Kai,Qin, Wei,Dong, Minghao,et al. Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals[J]. NEUROSCIENCE LETTERS,2010,482(2):101-105. |
APA | Yuan, Kai.,Qin, Wei.,Dong, Minghao.,Liu, Jixin.,Sun, Jinbo.,...&Tian, Jie.(2010).Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals.NEUROSCIENCE LETTERS,482(2),101-105. |
MLA | Yuan, Kai,et al."Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals".NEUROSCIENCE LETTERS 482.2(2010):101-105. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
106.Neuroscience Let(240KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 |
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