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Acid-Induced In Vivo Assembly of Gold Nanoparticles for Enhanced Photoacoustic Imaging-Guided Photothermal Therapy of Tumors
Zhang, Ruili1; Wang, Linlin1; Wang, Xiaofei1; Jia, Qian1; Chen, Zhuang1; Yang, Zuo1; Ji, Renchuan1; Tian, Jie1,2,3; Wang, Zhongliang1
Source PublicationADVANCED HEALTHCARE MATERIALS
ISSN2192-2640
2020-06-16
Pages10
Corresponding AuthorWang, Zhongliang(wangzl@xidian.edu.cn)
AbstractThe complexity of biological systems poses a great challenge in the development of nanotheranostic agents with enhanced therapeutic efficacies. To systematically overcome a series of barriers during in vivo administration and achieve optimal antitumor activity, nanotheranostic agents that can self-adaptively change their properties in response to certain tumor-associated signals are highly preferable. Herein, gold nanoparticles with a mixed-charge zwitterionic surface (Au-MUA-TMA) is fabricated, which can undergo pH-triggered self-assembly for promoting tumor targeting and improving photoacoustic imaging (PAI)-guided photothermal tumor ablation. In blood and normal tissues, relatively small-sized Au-MUA-TMA can circulate stably, and upon arriving at the tumor sites, they quickly assemble into larger aggregates in an acidic tumor environment to ensure higher tumor accumulation and retention. Furthermore, the absorption band of Au-MUA-TMA can be remarkably shifted to the near-infrared (NIR) region, which effectively activates the photoacoustic (PA) signals of tumors and enhances photothermal therapy (PTT) with minimal side effects. This in vivo self-assembly strategy enables the nanotheranostic agents to better fulfill multiple requirements for in vivo application, thereby attaining advanced performances in cancer diagnosis and treatment.
Keywordcancer theranostics gold nanoparticles in vivo self-assembly photothermal therapy tumor microenvironments
DOI10.1002/adhm.202000394
WOS KeywordDRUG-DELIVERY ; RAMAN-SCATTERING ; CELLULAR UPTAKE ; PH ; NANOTHERANOSTICS ; RETENTION ; NANOCAGES ; MICELLES ; RELEASE ; POLYMER
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFC1309100] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671753] ; National Natural Science Foundation of China[91959124] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[21804104] ; National Natural Science Foundation of China[81501524] ; National 1000 Young Talents Program of China ; Natural Science Foundation of Shaanxi Province[2019JQ-139] ; Natural Science Foundation of Shaanxi Province[2018JM2041] ; Fundamental Research Funds for the Central Universities[JB191211] ; Fundamental Research Funds for the Central Universities[JB191207] ; Fundamental Research Funds for the Central Universities[JB191208]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; National 1000 Young Talents Program of China ; Natural Science Foundation of Shaanxi Province ; Fundamental Research Funds for the Central Universities
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Materials Science
WOS SubjectEngineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS IDWOS:000540291400001
PublisherWILEY
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/39805
Collection中国科学院分子影像重点实验室
Corresponding AuthorWang, Zhongliang
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol & Neuroimaging, Minist Educ, Xian 710126, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ruili,Wang, Linlin,Wang, Xiaofei,et al. Acid-Induced In Vivo Assembly of Gold Nanoparticles for Enhanced Photoacoustic Imaging-Guided Photothermal Therapy of Tumors[J]. ADVANCED HEALTHCARE MATERIALS,2020:10.
APA Zhang, Ruili.,Wang, Linlin.,Wang, Xiaofei.,Jia, Qian.,Chen, Zhuang.,...&Wang, Zhongliang.(2020).Acid-Induced In Vivo Assembly of Gold Nanoparticles for Enhanced Photoacoustic Imaging-Guided Photothermal Therapy of Tumors.ADVANCED HEALTHCARE MATERIALS,10.
MLA Zhang, Ruili,et al."Acid-Induced In Vivo Assembly of Gold Nanoparticles for Enhanced Photoacoustic Imaging-Guided Photothermal Therapy of Tumors".ADVANCED HEALTHCARE MATERIALS (2020):10.
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