The Efficacy of COGnitive tRaining in patiEnts with Amnestic mild coGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial

doi:10.3233/JAD-191314

	The Efficacy of COGnitive tRaining in patiEnts with Amnestic mild coGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial
	Xing, Yi 1,2; Zhu, Zude 3; Du, Yifeng 4; Zhang, Junjian 5; Qu, Qiumin 6; Sun, Li 7,8; Li, Yang 9; Guo, Yanjun 10; Peng, Guoping 11; Liu, Yong12 ; Yu, Yueyi 1,2; Qiao, Yuchen 1,2; Xie, Beijia 1,2; Shi, Xinrui 1,2; Lu, Jie 13; Jia, Jianping 1,2; Tang, Yi 1,2
发表期刊	JOURNAL OF ALZHEIMERS DISEASE
ISSN	1387-2877
	2020
卷号	75 期号:3 页码:779-787
通讯作者	Tang, Yi(tangyi@xwhosp.org)
摘要	Background: Amnestic mild cognitive impairment (aMCI) is often the prodromal stage of Alzheimer's disease (AD). Although previous studies have suggested that computerized cognitive training is an effective non-pharmacological intervention for aMCI, large-sample, randomized controlled studies are warranted to provide a high level of evidence. Objective: To identify the efficacy of computerized cognitive training for aMCI. Methods: This study will include 260 patients diagnosed with aMCI from 8 centers in China. A computerized multi-domain adaptive training program will be used in this study, and the targeted cognitive domains include memory, attention, language, and executive function. The patients will be randomized into either a cognitive-training group or an active-control group. The intervention is a 12-week internet-based cognitive training performed for 40 minutes per day, 4 days a week. Neuropsychological assessments and structural and functional MRI will be obtained at baseline, at the end of the intervention, and 6 months after randomization. The primary outcome will be the global cognitive function score assessed by Montreal Cognitive Assessment. The secondary outcomes include changes in other neuropsychological assessments and neuroplasticity changes measured by structural and functional MRI. Results: The trial is currently ongoing, and it is anticipated that recruitment will be completed in December 2020. Conclusion: This multi-center, large-sample, randomized controlled trial will investigate the short and long-term effects of computerized cognitive training in patients with aMCI. Furthermore, the combination of functional and structural MRI results will also reveal the underlying mechanisms of the effect of intervention.
关键词	Cognitive training mild cognitive impairment non-pharmacological intervention randomized controlled clinical trial
DOI	10.3233/JAD-191314
关键词[WOS]	DEMENTIA ; PREVALENCE ; SHANGHAI ; SCALE
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2017YFC1310102] ; National Key R&D Program of China[2019YFC0118200] ; National Natural Science Foundation of China[81671040] ; National Natural Science Foundation of China[81970996] ; National Natural Science Foundation of China[81701044] ; Beijing Natural Science Foundation[JQ19024]
项目资助者	National Key R&D Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000541120800009
出版者	IOS PRESS
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/39910
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Tang, Yi
作者单位	1.Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Disorders, Innovat Ctr Neurol Disorders,Dept Neurol, Beijing, Peoples R China 2.Minist Educ Peoples Republ China, Key Lab Neurodegenerat Dis, Beijing, Peoples R China 3.Jiangsu Normal Univ, Collaborat Innovat Ctr Language Abil, Xuzhou, Jiangsu, Peoples R China 4.Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan, Peoples R China 5.Wuhan Univ, Zhongnan Hosp, Dept Neurol, Wuhan, Peoples R China 6.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Neurol, Xian, Peoples R China 7.First Hosp Jilin Univ, Dept Neurol, Changchun, Peoples R China 8.First Hosp Jilin Univ, Neurosci Ctr, Changchun, Peoples R China 9.Shanxi Med Univ, Hosp 1, Dept Neurol, Taiyuan, Peoples R China 10.Beijing Friendship Hosp, Dept Neurol, Beijing, Peoples R China 11.Zhejiang Univ, Affiliated Hosp 1, Dept Neurol, Hangzhou, Peoples R China 12.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 13.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xing, Yi,Zhu, Zude,Du, Yifeng,et al. The Efficacy of COGnitive tRaining in patiEnts with Amnestic mild coGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial[J]. JOURNAL OF ALZHEIMERS DISEASE,2020,75(3):779-787.
APA	Xing, Yi.,Zhu, Zude.,Du, Yifeng.,Zhang, Junjian.,Qu, Qiumin.,...&Tang, Yi.(2020).The Efficacy of COGnitive tRaining in patiEnts with Amnestic mild coGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial.JOURNAL OF ALZHEIMERS DISEASE,75(3),779-787.
MLA	Xing, Yi,et al."The Efficacy of COGnitive tRaining in patiEnts with Amnestic mild coGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial".JOURNAL OF ALZHEIMERS DISEASE 75.3(2020):779-787.