Spatial-Temporal Dependency Modeling and Network Hub Detection for Functional MRI Analysis via Convolutional-Recurrent Network | |
Wang, Mingliang1; Lian, Chunfeng2,3; Yao, Dongren4,5; Zhang, Daoqiang1; Liu, Mingxia2,3; Shen, Dinggang2,3,6 | |
发表期刊 | IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING |
ISSN | 0018-9294 |
2020-08-01 | |
卷号 | 67期号:8页码:2241-2252 |
摘要 | Early identification of dementia at the stage of mild cognitive impairment (MCI) is crucial for timely diagnosis and intervention of Alzheimer's disease (AD). Although several pioneering studies have been devoted to automated AD diagnosis based on resting-state functional magnetic resonance imaging (rs-fMRI), their performance is somewhat limited due to non-effective mining of spatial-temporal dependency. Besides, few of these existing approaches consider the explicit detection and modeling of discriminative brain regions (i.e., network hubs) that are sensitive to AD progression. In this paper, we propose a unique Spatial-Temporal convolutional-recurrent neural Network (STNet) for automated prediction of AD progression and network hub detection from rs-fMRI time series. Our STNet incorporates the spatial-temporal information mining and AD-related hub detection into an end-to-end deep learning model. Specifically, we first partition rs-fMRI time series into a sequence of overlapping sliding windows. A sequence of convolutional components are then designed to capture the local-to-global spatially-dependent patterns within each sliding window, based on which we are able to identify discriminative hubs and characterize their unique contributions to disease diagnosis. A recurrent component with long short-term memory (LSTM) units is further employed to model the whole-brain temporal dependency from the spatially-dependent pattern sequences, thus capturing the temporal dynamics along time. We evaluate the proposed method on 174 subjects with 563 rs-fMRI scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, with results suggesting the effectiveness of our method in both tasks of disease progression prediction and AD-related hub detection. |
关键词 | Spatial-temporal dependency neural network Alzheimer's disease hub detection resting-state functional MRI |
DOI | 10.1109/TBME.2019.2957921 |
关键词[WOS] | MILD COGNITIVE IMPAIRMENT ; CONNECTIVITY NETWORKS ; ALZHEIMERS ; PROGRESSION ; MCI |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[61732006] ; National Natural Science Foundation of China[61876082] ; National Natural Science Foundation of China[61861130366] ; National Natural Science Foundation of China[61703301] ; Royal Society-Academy of Medical Sciences Newton Advanced Fellowship[NAF\R1\180371] ; Fundamental Research Funds for the Central Universities[NP2018104] ; National Key R&D Program of China[2018YFC2001600] ; National Key R&D Program of China[2018YFC2001602] ; National Institutes of Health[AG041721] ; National Institutes of Health[EB022880] |
项目资助者 | National Natural Science Foundation of China ; Royal Society-Academy of Medical Sciences Newton Advanced Fellowship ; Fundamental Research Funds for the Central Universities ; National Key R&D Program of China ; National Institutes of Health |
WOS研究方向 | Engineering |
WOS类目 | Engineering, Biomedical |
WOS记录号 | WOS:000550653800010 |
出版者 | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/40207 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
通讯作者 | Zhang, Daoqiang; Liu, Mingxia; Shen, Dinggang |
作者单位 | 1.Nanjing Univ Aeronaut & Astronaut, Coll Comp Sci & Technol, MIIT Key Lab Pattern Anal & Machine Intelligence, Nanjing 211106, Peoples R China 2.Univ N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA 3.Univ N Carolina, BRIC, Chapel Hill, NC 27515 USA 4.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China 5.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China 6.Korea Univ, Dept Brain & Cognit Engn, Seoul 02841, South Korea |
推荐引用方式 GB/T 7714 | Wang, Mingliang,Lian, Chunfeng,Yao, Dongren,et al. Spatial-Temporal Dependency Modeling and Network Hub Detection for Functional MRI Analysis via Convolutional-Recurrent Network[J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,2020,67(8):2241-2252. |
APA | Wang, Mingliang,Lian, Chunfeng,Yao, Dongren,Zhang, Daoqiang,Liu, Mingxia,&Shen, Dinggang.(2020).Spatial-Temporal Dependency Modeling and Network Hub Detection for Functional MRI Analysis via Convolutional-Recurrent Network.IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,67(8),2241-2252. |
MLA | Wang, Mingliang,et al."Spatial-Temporal Dependency Modeling and Network Hub Detection for Functional MRI Analysis via Convolutional-Recurrent Network".IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 67.8(2020):2241-2252. |
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