Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies | |
Cao, Xin1; Chen, Xueli1; Kang, Fei2; Lin, Yenan1; Liu, Muhan1; Hu, Hao3; Nie, Yongzhan3; Wu, Kaichun3; Wang, Jing2; Liang, Jimin1; Tian, Jie1,4 | |
发表期刊 | BIOMEDICAL OPTICS EXPRESS |
2014-10-01 | |
卷号 | 5期号:10页码:3660-3670 |
文章类型 | Article |
摘要 | By integrating the clinically used endoscope with the emerging Cerenkov luminescence imaging (CLI) technology, a new endoscopic Cerenkov luminescence imaging (ECLI) system was developed. The aim is to demonstrate the potential of translating CLI to clinical studies of gastrointestinal (GI) tract diseases. We systematically evaluated the feasibility and performance of the developed ECLI system with a series of in vitro and pseudotumor experiments. The ECLI system is comprised of an electron multiplying charge coupled device (EMCCD) camera coupled with a clinically used endoscope via an optical adapter. A 1951-USAF test board was used to measure the white-light lateral resolution, while a homemade test chart filled with Ga-68 was employed to measure the CL lateral resolution. Both in vitro and pseudotumor experiments were conducted to obtain the sensitivity of the ECLI system. The results were validated with that of CLI using EMCCD only, and the relative attenuation ratio of the ECLI system was calculated. Results showed that The white-light lateral resolution of the ECLI system was 198 mu m, and the luminescent lateral resolution was better than 1 mm. Sensitivity experiments showed a theoretical sensitivity of 0.186 KBq / mu l (5.033x10(-3) mu Ci / mu l) and 1.218 KBq / mu l (32.922x10(-3) mu Ci / mu l) for the in vitro and pseudotumor studies, respectively. The relative attenuation ratio of ECLI to CLI was about 96%. The luminescent lateral resolution of the ECLI system was comparable with that of positron emission tomography (PET). The pseudotumor study illustrated the feasibility and applicability of the ECLI system in living organisms, indicating the potential for translating the CLI technology to the clinic. (C)2014 Optical Society of America |
关键词 | Light Propagation In Tissues Turbid Media Tissue Characterization |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
关键词[WOS] | GASTROINTESTINAL STROMAL TUMORS ; CANCER STATISTICS ; RADIATION ; F-18-FDG ; PET/CT ; CT |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000343135200032 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/4034 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Tian, Jie |
作者单位 | 1.Xidian Univ, Engn Res Ctr Mol & Neuroimaging, Sch Life Sci & Technol, Minist Educ, Xian 710071, Shaanxi, Peoples R China 2.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Shaanxi, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Dept Digest Dis, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China |
通讯作者单位 | 中国科学院自动化研究所 |
推荐引用方式 GB/T 7714 | Cao, Xin,Chen, Xueli,Kang, Fei,et al. Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies[J]. BIOMEDICAL OPTICS EXPRESS,2014,5(10):3660-3670. |
APA | Cao, Xin.,Chen, Xueli.,Kang, Fei.,Lin, Yenan.,Liu, Muhan.,...&Tian, Jie.(2014).Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies.BIOMEDICAL OPTICS EXPRESS,5(10),3660-3670. |
MLA | Cao, Xin,et al."Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies".BIOMEDICAL OPTICS EXPRESS 5.10(2014):3660-3670. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
boe-5-10-3660.pdf(2689KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论