CASIA OpenIR  > 中国科学院分子影像重点实验室
Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies
Cao, Xin1; Chen, Xueli1; Kang, Fei2; Lin, Yenan1; Liu, Muhan1; Hu, Hao3; Nie, Yongzhan3; Wu, Kaichun3; Wang, Jing2; Liang, Jimin1; Tian, Jie1,4
Source PublicationBIOMEDICAL OPTICS EXPRESS
2014-10-01
Volume5Issue:10Pages:3660-3670
SubtypeArticle
AbstractBy integrating the clinically used endoscope with the emerging Cerenkov luminescence imaging (CLI) technology, a new endoscopic Cerenkov luminescence imaging (ECLI) system was developed. The aim is to demonstrate the potential of translating CLI to clinical studies of gastrointestinal (GI) tract diseases. We systematically evaluated the feasibility and performance of the developed ECLI system with a series of in vitro and pseudotumor experiments. The ECLI system is comprised of an electron multiplying charge coupled device (EMCCD) camera coupled with a clinically used endoscope via an optical adapter. A 1951-USAF test board was used to measure the white-light lateral resolution, while a homemade test chart filled with Ga-68 was employed to measure the CL lateral resolution. Both in vitro and pseudotumor experiments were conducted to obtain the sensitivity of the ECLI system. The results were validated with that of CLI using EMCCD only, and the relative attenuation ratio of the ECLI system was calculated. Results showed that The white-light lateral resolution of the ECLI system was 198 mu m, and the luminescent lateral resolution was better than 1 mm. Sensitivity experiments showed a theoretical sensitivity of 0.186 KBq / mu l (5.033x10(-3) mu Ci / mu l) and 1.218 KBq / mu l (32.922x10(-3) mu Ci / mu l) for the in vitro and pseudotumor studies, respectively. The relative attenuation ratio of ECLI to CLI was about 96%. The luminescent lateral resolution of the ECLI system was comparable with that of positron emission tomography (PET). The pseudotumor study illustrated the feasibility and applicability of the ECLI system in living organisms, indicating the potential for translating the CLI technology to the clinic. (C)2014 Optical Society of America
KeywordLight Propagation In Tissues Turbid Media Tissue Characterization
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS KeywordGASTROINTESTINAL STROMAL TUMORS ; CANCER STATISTICS ; RADIATION ; F-18-FDG ; PET/CT ; CT
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000343135200032
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4034
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Xidian Univ, Engn Res Ctr Mol & Neuroimaging, Sch Life Sci & Technol, Minist Educ, Xian 710071, Shaanxi, Peoples R China
2.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Shaanxi, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Dept Digest Dis, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Cao, Xin,Chen, Xueli,Kang, Fei,et al. Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies[J]. BIOMEDICAL OPTICS EXPRESS,2014,5(10):3660-3670.
APA Cao, Xin.,Chen, Xueli.,Kang, Fei.,Lin, Yenan.,Liu, Muhan.,...&Tian, Jie.(2014).Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies.BIOMEDICAL OPTICS EXPRESS,5(10),3660-3670.
MLA Cao, Xin,et al."Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies".BIOMEDICAL OPTICS EXPRESS 5.10(2014):3660-3670.
Files in This Item: Download All
File Name/Size DocType Version Access License
boe-5-10-3660.pdf(2689KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cao, Xin]'s Articles
[Chen, Xueli]'s Articles
[Kang, Fei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cao, Xin]'s Articles
[Chen, Xueli]'s Articles
[Kang, Fei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cao, Xin]'s Articles
[Chen, Xueli]'s Articles
[Kang, Fei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: boe-5-10-3660.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.