CASIA OpenIR  > 中国科学院分子影像重点实验室
Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification
Zhang, Jun1; Chen, Duofang1; Liang, Jimin1; Xue, Huadan2; Lei, Jing2; Wang, Qin2; Chen, Dongmei1; Meng, Ming2; Jin, Zhengyu2; Tian, Jie1,3
Source PublicationBIOMEDICAL OPTICS EXPRESS
2014-06-01
Volume5Issue:6Pages:1861-1876
SubtypeArticle
AbstractCombining two or more imaging modalities to provide complementary information has become commonplace in clinical practice and in preclinical and basic biomedical research. By incorporating the structural information provided by computed tomography (CT) or magnetic resonance imaging (MRI), the ill poseness nature of bioluminescence tomography (BLT) can be reduced significantly, thus improve the accuracies of reconstruction and in vivo quantification. In this paper, we present a small animal imaging system combining multi-view and multi-spectral BLT with MRI. The independent MRI-compatible optical device is placed at the end of the clinical MRI scanner. The small animal is transferred between the light tight chamber of the optical device and the animal coil of MRI via a guide rail during the experiment. After the optical imaging and MRI scanning procedures are finished, the optical images are mapped onto the MRI surface by interactive registration between boundary of optical images and silhouette of MRI. Then, incorporating the MRI structural information, a heterogeneous reconstruction algorithm based on finite element method (FEM) with L-1 normalization is used to reconstruct the position, power and region of the light source. In order to validate the feasibility of the system, we conducted experiments of nude mice model implanted with artificial light source and quantitative analysis of tumor inoculation model with MDA-231-GFP-luc. Preliminary results suggest the feasibility and effectiveness of the prototype system. (C) 2014 Optical Society of America
KeywordImaging Systems Medical And Biological Imaging Tomographic Imaging
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS KeywordDIFFUSE OPTICAL TOMOGRAPHY ; FLUORESCENCE TOMOGRAPHY ; IMAGE-RECONSTRUCTION ; RADIATIVE-TRANSFER ; MOUSE MODELS ; BREAST ; TISSUE ; SIMULATION ; ALGORITHM ; APPROXIMATION
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000337503900013
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Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4036
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Beijing Union Med Coll Hosp, Beijing 100730, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Jun,Chen, Duofang,Liang, Jimin,et al. Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification[J]. BIOMEDICAL OPTICS EXPRESS,2014,5(6):1861-1876.
APA Zhang, Jun.,Chen, Duofang.,Liang, Jimin.,Xue, Huadan.,Lei, Jing.,...&Tian, Jie.(2014).Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification.BIOMEDICAL OPTICS EXPRESS,5(6),1861-1876.
MLA Zhang, Jun,et al."Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification".BIOMEDICAL OPTICS EXPRESS 5.6(2014):1861-1876.
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