| Multiscale neurobiological correlates of human neuroticism | |
Xu, Qiang1,2; Liu, Feng1,2; Qin, Wen1,2; Jiang, Tianzi3,4 ; Yu, Chunshui1,2,4
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| 发表期刊 | HUMAN BRAIN MAPPING
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| ISSN | 1065-9471 |
| 2020-08-17 | |
| 页码 | 14 |
| 通讯作者 | Yu, Chunshui(chunshuiyu@tijmu.edu.cn) |
| 摘要 | Neuroticism is a heritable personality trait associated with negative emotionality; however, we know little regarding the association between the microscale and macroscale neurobiological substrates of human neuroticism. Cross-scale correlation analysis may provide such information. In this study, voxel-wise neuroimaging-neuroticism correlation analyses consistently showed a positive correlation between neuroticism and functional connectivity density (FCD) in the ventral striatum in 274 young Chinese adults. Partial least squares regression analysis showed that the FCD-neuroticism correlation map was significantly spatially correlated with gene expression profiles in each of six donated human brains. Neuroticism-related genes derived from the six donors consistently showed significant enrichment in the chemical synaptic transmission, circadian entrainment, long-term potentiation, inflammatory mediator regulation of transient receptor potential channels, and amphetamine addiction pathways. The protein-protein interaction analysis revealed four hub genes involved in the above pathways, including G protein subunit gamma 10, 5-hydroxytryptamine receptor 2C, prodynorphin, and calcium/calmodulin-dependent protein kinase II alpha. By combining multiscale correlation analyses and functional annotations, this study advances our understanding of the genetic and neural substrates of human neuroticism and emphasizes the importance of striatal functional properties in human neuroticism. |
| 关键词 | Allen human brain atlas functional connectivity density gene expression neuroticism ventral striatum |
| DOI | 10.1002/hbm.25153 |
| 关键词[WOS] | PARTIAL LEAST-SQUARES ; SEROTONIN 5-HT2C RECEPTORS ; FUNCTIONAL CONNECTIVITY ; BRAIN ; EXPRESSION ; ANXIETY ; MRI ; EXTROVERSION ; MECHANISMS ; NETWORKS |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Key Research and Development Program of China[2018YFC1314300] ; National Natural Science Foundation of China[81425013] ; National Natural Science Foundation of China[81501451] ; Natural Science Foundation of Tianjin[18JCQNJC10900] ; Natural Science Foundation of Tianjin[17JCZDJC36300] ; Research Fund for Young Scholars of Tianjin Medical University General Hospital[ZYYFY2018007] ; Tianjin Key Technology RD Program[17ZXMFSY00090] |
| 项目资助者 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Tianjin ; Research Fund for Young Scholars of Tianjin Medical University General Hospital ; Tianjin Key Technology RD Program |
| WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS记录号 | WOS:000560447600001 |
| 出版者 | WILEY |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/40423 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 通讯作者 | Yu, Chunshui |
| 作者单位 | 1.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin 300052, Peoples R China 2.Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Gen Hosp, Tianjin 300052, Peoples R China 3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Qiang,Liu, Feng,Qin, Wen,et al. Multiscale neurobiological correlates of human neuroticism[J]. HUMAN BRAIN MAPPING,2020:14. |
| APA | Xu, Qiang,Liu, Feng,Qin, Wen,Jiang, Tianzi,&Yu, Chunshui.(2020).Multiscale neurobiological correlates of human neuroticism.HUMAN BRAIN MAPPING,14. |
| MLA | Xu, Qiang,et al."Multiscale neurobiological correlates of human neuroticism".HUMAN BRAIN MAPPING (2020):14. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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