| Multiscale neurobiological correlates of human neuroticism | |
Xu, Qiang1,2; Liu, Feng1,2; Qin, Wen1,2; Jiang, Tianzi3,4 ; Yu, Chunshui1,2,4
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| Source Publication | HUMAN BRAIN MAPPING
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| ISSN | 1065-9471 |
| 2020-08-17 | |
| Pages | 14 |
| Corresponding Author | Yu, Chunshui(chunshuiyu@tijmu.edu.cn) |
| Abstract | Neuroticism is a heritable personality trait associated with negative emotionality; however, we know little regarding the association between the microscale and macroscale neurobiological substrates of human neuroticism. Cross-scale correlation analysis may provide such information. In this study, voxel-wise neuroimaging-neuroticism correlation analyses consistently showed a positive correlation between neuroticism and functional connectivity density (FCD) in the ventral striatum in 274 young Chinese adults. Partial least squares regression analysis showed that the FCD-neuroticism correlation map was significantly spatially correlated with gene expression profiles in each of six donated human brains. Neuroticism-related genes derived from the six donors consistently showed significant enrichment in the chemical synaptic transmission, circadian entrainment, long-term potentiation, inflammatory mediator regulation of transient receptor potential channels, and amphetamine addiction pathways. The protein-protein interaction analysis revealed four hub genes involved in the above pathways, including G protein subunit gamma 10, 5-hydroxytryptamine receptor 2C, prodynorphin, and calcium/calmodulin-dependent protein kinase II alpha. By combining multiscale correlation analyses and functional annotations, this study advances our understanding of the genetic and neural substrates of human neuroticism and emphasizes the importance of striatal functional properties in human neuroticism. |
| Keyword | Allen human brain atlas functional connectivity density gene expression neuroticism ventral striatum |
| DOI | 10.1002/hbm.25153 |
| WOS Keyword | PARTIAL LEAST-SQUARES ; SEROTONIN 5-HT2C RECEPTORS ; FUNCTIONAL CONNECTIVITY ; BRAIN ; EXPRESSION ; ANXIETY ; MRI ; EXTROVERSION ; MECHANISMS ; NETWORKS |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2018YFC1314300] ; National Natural Science Foundation of China[81425013] ; National Natural Science Foundation of China[81501451] ; Natural Science Foundation of Tianjin[18JCQNJC10900] ; Natural Science Foundation of Tianjin[17JCZDJC36300] ; Research Fund for Young Scholars of Tianjin Medical University General Hospital[ZYYFY2018007] ; Tianjin Key Technology RD Program[17ZXMFSY00090] |
| Funding Organization | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Tianjin ; Research Fund for Young Scholars of Tianjin Medical University General Hospital ; Tianjin Key Technology RD Program |
| WOS Research Area | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS Subject | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS ID | WOS:000560447600001 |
| Publisher | WILEY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/40423 |
| Collection | 脑网络组研究 |
| Corresponding Author | Yu, Chunshui |
| Affiliation | 1.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin 300052, Peoples R China 2.Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Gen Hosp, Tianjin 300052, Peoples R China 3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China |
| Recommended Citation GB/T 7714 | Xu, Qiang,Liu, Feng,Qin, Wen,et al. Multiscale neurobiological correlates of human neuroticism[J]. HUMAN BRAIN MAPPING,2020:14. |
| APA | Xu, Qiang,Liu, Feng,Qin, Wen,Jiang, Tianzi,&Yu, Chunshui.(2020).Multiscale neurobiological correlates of human neuroticism.HUMAN BRAIN MAPPING,14. |
| MLA | Xu, Qiang,et al."Multiscale neurobiological correlates of human neuroticism".HUMAN BRAIN MAPPING (2020):14. |
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