Single photon emission computed tomography-guided Cerenkov luminescence tomography

	Single photon emission computed tomography-guided Cerenkov luminescence tomography
	Hu, Zhenhua1 ; Chen, Xueli 1; Liang, Jimin 1; Qu, Xiaochao 1; Chen, Duofang 1; Yang, Weidong 3; Wang, Jing 3; Cao, Feng 4; Tian, Jie 1,2
发表期刊	JOURNAL OF APPLIED PHYSICS
	2012-07-15
卷号	112 期号:2 页码:-
文章类型	Article
摘要	Cerenkov luminescence tomography (CLT) has become a valuable tool for preclinical imaging because of its ability of reconstructing the three-dimensional distribution and activity of the radiopharmaceuticals. However, it is still far from a mature technology and suffers from relatively low spatial resolution due to the ill-posed inverse problem for the tomographic reconstruction. In this paper, we presented a single photon emission computed tomography (SPECT)-guided reconstruction method for CLT, in which a priori information of the permissible source region (PSR) from SPECT imaging results was incorporated to effectively reduce the ill-posedness of the inverse reconstruction problem. The performance of the method was first validated with the experimental reconstruction of an adult athymic nude mouse implanted with a (NaI)-I-131 radioactive source and an adult athymic nude mouse received an intravenous tail injection of (NaI)-I-131. A tissue-mimic phantom based experiment was then conducted to illustrate the ability of the proposed method in resolving double sources. Compared with the traditional PSR strategy in which the PSR was determined by the surface flux distribution, the proposed method obtained much more accurate and encouraging localization and resolution results. Preliminary results showed that the proposed SPECT-guided reconstruction method was insensitive to the regularization methods and ignored the heterogeneity of tissues which can avoid the segmentation procedure of the organs. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4739266]
关键词	-
WOS标题词	Science & Technology ; Physical Sciences
关键词[WOS]	BIOLUMINESCENCE TOMOGRAPHY ; RECONSTRUCTION ; RADIATION ; FEASIBILITY ; SIMULATION ; MODEL ; PET
收录类别	SCI
语种	英语
WOS研究方向	Physics
WOS类目	Physics, Applied
WOS记录号	WOS:000308424500136
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4071
专题	中国科学院分子影像重点实验室
通讯作者	Liang, Jimin; Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 3.Fourth Mil Med Univ, Dept Nucl Med, Xijing Hosp, Xian 710032, Peoples R China 4.Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Hu, Zhenhua,Chen, Xueli,Liang, Jimin,et al. Single photon emission computed tomography-guided Cerenkov luminescence tomography[J]. JOURNAL OF APPLIED PHYSICS,2012,112(2):-.
APA	Hu, Zhenhua.,Chen, Xueli.,Liang, Jimin.,Qu, Xiaochao.,Chen, Duofang.,...&Tian, Jie.(2012).Single photon emission computed tomography-guided Cerenkov luminescence tomography.JOURNAL OF APPLIED PHYSICS,112(2),-.
MLA	Hu, Zhenhua,et al."Single photon emission computed tomography-guided Cerenkov luminescence tomography".JOURNAL OF APPLIED PHYSICS 112.2(2012):-.

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