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Altered functional brain networks in Prader-Willi syndrome
Zhang, Yi1,2; Zhao, Heng1; Qiu, Siyou1; Tian, Jie1,3; Wen, Xiaotong4; Miller, Jennifer L.5; von Deneen, Karen M.1,2; Zhou, Zhenyu6; Gold, Mark S.2; Liu, Yijun2,6
Source PublicationNMR IN BIOMEDICINE
AbstractPraderWilli syndrome (PWS) is a genetic imprinting disorder characterized mainly by hyperphagia and early childhood obesity. Previous functional neuroimaging studies used visual stimuli to examine abnormal activities in the eating-related neural circuitry of patients with PWS. It was found that patients with PWS exhibited both excessive hunger and hyperphagia consistently, even in situations without any food stimulation. In the present study, we employed resting-state functional MRI techniques to investigate abnormal brain networks related to eating disorders in children with PWS. First, we applied amplitude of low-frequency fluctuation analysis to define the regions of interest that showed significant alterations in resting-state brain activity levels in patients compared with their sibling control group. We then applied a functional connectivity (FC) analysis to these regions of interest in order to characterize interactions among the brain regions. Our results demonstrated that patients with PWS showed decreased FC strength in the medial prefrontal cortex (MPFC)/inferior parietal lobe (IPL), MPFC/precuneus, IPL/precuneus and IPL/hippocampus in the default mode network; decreased FC strength in the pre-/postcentral gyri and dorsolateral prefrontal cortex (DLPFC)/orbitofrontal cortex (OFC) in the motor sensory network and prefrontal cortex network, respectively; and increased FC strength in the anterior cingulate cortex/insula, ventrolateral prefrontal cortex (VLPFC)/OFC and DLPFC/VLPFC in the core network and prefrontal cortex network, respectively. These findings indicate that there are FC alterations among the brain regions implicated in eating as well as rewarding, even during the resting state, which may provide further evidence supporting the use of PWS as a model to study obesity and to provide information on potential neural targets for the medical treatment of overeating. Copyright (c) 2013 John Wiley & Sons, Ltd.
KeywordPrader-willi Syndrome Eating Disorder Obesity Amplitude Of Low-frequency Fluctuation Resting-state Networks Nctional Mri
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Technology
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(60901064 ; Fundamental Research Funds for the Central Universities ; Brain and Behavior Research Foundation (NARSAD) ; 81271549 ; 60903127 ; 61131003)
WOS Research AreaBiophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS SubjectBiophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS IDWOS:000318231700004
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Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorTian, Jie
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
2.Univ Florida, Dept Psychiat, Gainesville, FL 32610 USA
3.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
4.Univ Florida, J Crayton Pruitt Family Dept Biomed Engn, Gainesville, FL 32610 USA
5.Univ Florida, Coll Med, Dept Pediat, Gainesville, FL 32610 USA
6.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Yi,Zhao, Heng,Qiu, Siyou,et al. Altered functional brain networks in Prader-Willi syndrome[J]. NMR IN BIOMEDICINE,2013,26(6):622-629.
APA Zhang, Yi.,Zhao, Heng.,Qiu, Siyou.,Tian, Jie.,Wen, Xiaotong.,...&Liu, Yijun.(2013).Altered functional brain networks in Prader-Willi syndrome.NMR IN BIOMEDICINE,26(6),622-629.
MLA Zhang, Yi,et al."Altered functional brain networks in Prader-Willi syndrome".NMR IN BIOMEDICINE 26.6(2013):622-629.
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