Altered functional brain networks in Prader-Willi syndrome

doi:10.1002/nbm.2900

	Altered functional brain networks in Prader-Willi syndrome
	Zhang, Yi 1,2; Zhao, Heng 1; Qiu, Siyou 1; Tian, Jie 1,3; Wen, Xiaotong 4; Miller, Jennifer L.5; von Deneen, Karen M.1,2; Zhou, Zhenyu 6; Gold, Mark S.2; Liu, Yijun 2,6
发表期刊	NMR IN BIOMEDICINE
	2013-06-01
卷号	26 期号:6 页码:622-629
文章类型	Article
摘要	PraderWilli syndrome (PWS) is a genetic imprinting disorder characterized mainly by hyperphagia and early childhood obesity. Previous functional neuroimaging studies used visual stimuli to examine abnormal activities in the eating-related neural circuitry of patients with PWS. It was found that patients with PWS exhibited both excessive hunger and hyperphagia consistently, even in situations without any food stimulation. In the present study, we employed resting-state functional MRI techniques to investigate abnormal brain networks related to eating disorders in children with PWS. First, we applied amplitude of low-frequency fluctuation analysis to define the regions of interest that showed significant alterations in resting-state brain activity levels in patients compared with their sibling control group. We then applied a functional connectivity (FC) analysis to these regions of interest in order to characterize interactions among the brain regions. Our results demonstrated that patients with PWS showed decreased FC strength in the medial prefrontal cortex (MPFC)/inferior parietal lobe (IPL), MPFC/precuneus, IPL/precuneus and IPL/hippocampus in the default mode network; decreased FC strength in the pre-/postcentral gyri and dorsolateral prefrontal cortex (DLPFC)/orbitofrontal cortex (OFC) in the motor sensory network and prefrontal cortex network, respectively; and increased FC strength in the anterior cingulate cortex/insula, ventrolateral prefrontal cortex (VLPFC)/OFC and DLPFC/VLPFC in the core network and prefrontal cortex network, respectively. These findings indicate that there are FC alterations among the brain regions implicated in eating as well as rewarding, even during the resting state, which may provide further evidence supporting the use of PWS as a model to study obesity and to provide information on potential neural targets for the medical treatment of overeating. Copyright (c) 2013 John Wiley & Sons, Ltd.
关键词	Prader-willi Syndrome Eating Disorder Obesity Amplitude Of Low-frequency Fluctuation Resting-state Networks Nctional Mri
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Technology
DOI	10.1002/nbm.2900
关键词[WOS]	RESTING-STATE NETWORKS ; POSITRON-EMISSION-TOMOGRAPHY ; ANTERIOR CINGULATE CORTEX ; TOP-DOWN CONTROL ; PREFRONTAL CORTEX ; FOOD ADDICTION ; NEURAL CIRCUITRY ; ANGELMAN-SYNDROMES ; OBESITY ; ACTIVATION
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(60901064 ; Fundamental Research Funds for the Central Universities ; Brain and Behavior Research Foundation (NARSAD) ; 81271549 ; 60903127 ; 61131003)
WOS研究方向	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS类目	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS记录号	WOS:000318231700004
引用统计	被引频次：34[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4097
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 2.Univ Florida, Dept Psychiat, Gainesville, FL 32610 USA 3.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 4.Univ Florida, J Crayton Pruitt Family Dept Biomed Engn, Gainesville, FL 32610 USA 5.Univ Florida, Coll Med, Dept Pediat, Gainesville, FL 32610 USA 6.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Zhang, Yi,Zhao, Heng,Qiu, Siyou,et al. Altered functional brain networks in Prader-Willi syndrome[J]. NMR IN BIOMEDICINE,2013,26(6):622-629.
APA	Zhang, Yi.,Zhao, Heng.,Qiu, Siyou.,Tian, Jie.,Wen, Xiaotong.,...&Liu, Yijun.(2013).Altered functional brain networks in Prader-Willi syndrome.NMR IN BIOMEDICINE,26(6),622-629.
MLA	Zhang, Yi,et al."Altered functional brain networks in Prader-Willi syndrome".NMR IN BIOMEDICINE 26.6(2013):622-629.

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