Structural and functional abnormalities in migraine patients without aura

	Structural and functional abnormalities in migraine patients without aura
	Jin, Chenwang 1; Yuan, Kai 2; Zhao, Limei 2; Zhao, Ling 3; Yu, Dahua 2,4; von Deneen, Karen M.2; Zhang, Ming1 ; Qin, Wei 2; Sun, Weixin 5; Tian, Jie 2,6
发表期刊	NMR IN BIOMEDICINE
	2013
卷号	26 期号:1 页码:58-64
文章类型	Article
摘要	Migraine is a primary headache disorder characterized by recurrent attacks of throbbing pain associated with neurological, gastrointestinal and autonomic symptoms. Previous studies have detected structural deficits and functional impairments in migraine patients. However, researchers have failed to investigate the functional connectivity alterations of regions with structural deficits during the resting state. Twenty-one migraine patients without aura and 21 age-and gender-matched healthy controls participated in our study. Voxel-based morphometric (VBM) analysis and functional connectivity were employed to investigate the abnormal structural and resting-state properties, respectively, in migraine patients without aura. Relative to healthy comparison subjects, migraine patients showed significantly decreased gray matter volume in five brain regions: the left medial prefrontal cortex (MPFC), dorsal anterior cingulate cortex (dACC), right occipital lobe, cerebellum and brainstem. The gray matter volume of the dACC was correlated with the duration of disease in migraine patients, and thus we chose this region as the seeding area for resting-state analysis. We found that migraine patients showed increased functional connectivity between several regions and the left dACC, i.e. the bilateral middle temporal lobe, orbitofrontal cortex (OFC) and left dorsolateral prefrontal cortex (DLPFC). Furthermore, the functional connectivity between the dACC and two regions (i.e. DLPFC and OFC) was correlated with the duration of disease in migraine patients. We suggest that frequent nociceptive input has modified the structural and functional patterns of the frontal cortex, and these changes may explain the functional impairments in migraine patients. Copyright (C) 2012 John Wiley & Sons, Ltd.
关键词	Migraine Voxel-based Morphometric (Vbm) Resting State Functional Connectivity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Technology
关键词[WOS]	VOXEL-BASED MORPHOMETRY ; HEROIN-DEPENDENT INDIVIDUALS ; BRAIN-STEM ACTIVATION ; GREY-MATTER CHANGES ; RESTING-STATE FMRI ; GRAY-MATTER ; ALZHEIMERS-DISEASE ; ANTERIOR CINGULATE ; NEURAL ACTIVITY ; MR-IMAGES
收录类别	SCI
语种	英语
WOS研究方向	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS类目	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS记录号	WOS:000313886200007
引用统计	被引频次：142[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4099
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Xi An Jiao Tong Univ, Dept Med Imaging, Affiliated Hosp 1, Xian 710049, Shaanxi, Peoples R China 2.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 3.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Sichuan, Peoples R China 4.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Informat Proc Lab, Baotou, Inner Mongolia, Peoples R China 5.Xi An Jiao Tong Univ, Inst Biomed Engn, Key Lab Biomed Informat Engn, Minist Educ,Med Coll,Med Sch,Affiliated Hosp 1, Xian 710049, Shaanxi, Peoples R China 6.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Jin, Chenwang,Yuan, Kai,Zhao, Limei,et al. Structural and functional abnormalities in migraine patients without aura[J]. NMR IN BIOMEDICINE,2013,26(1):58-64.
APA	Jin, Chenwang.,Yuan, Kai.,Zhao, Limei.,Zhao, Ling.,Yu, Dahua.,...&Tian, Jie.(2013).Structural and functional abnormalities in migraine patients without aura.NMR IN BIOMEDICINE,26(1),58-64.
MLA	Jin, Chenwang,et al."Structural and functional abnormalities in migraine patients without aura".NMR IN BIOMEDICINE 26.1(2013):58-64.

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