CASIA OpenIR  > 综合信息系统研究中心
BUILDING AND EVALUATING AN ANIMAL MODEL FOR SYNDROME IN TRADITIONAL CHINESE MEDICINE IN THE CONTEXT OF UNSTABLE ANGINA (MYOCARDIAL ISCHEMIA) BY SUPERVISED DATA MINING APPROACHES
Guo, Shuzhen1; Chen, Jianxin1; Zhao, Huihui1; Wang, Wei1; Yi, Jianqiang2; Liu, Lei1; Qi, Qige1; Liu, Renquan1; Qiu, Qi1; Wang, Yong1
Source PublicationJOURNAL OF BIOLOGICAL SYSTEMS
2009-12-01
Volume17Issue:4Pages:531-546
SubtypeArticle
AbstractBuilding an animal model for a disease is a better avenue to understand the inner mechanism of it. Traditional Chinese Medicine accumulated much practical experience and a large amount of literature to heal diseases during the past 3000 years. However, as there is no available animal model for TCM research because syndrome, the core of TCM theory, it is hard to be diagnosed from animals. In this paper, we present a novel strategy to build and evaluate an animal model for syndrome in TCM in the context of a disease. We first carried out a clinical epidemiology survey for a syndrome ( Blood stasis syndrome, BSS) diagnosed by TCM experts in the context of a disease ( Unstable angina, UA). Meanwhile, the blood samples of patients included in the survey were collected and measured as physical and chemical specifications by laboratory examinations. Alternatively, we used supervised data mining methods to build association between the specifications and the syndrome in the context of UA. The accuracy of classification was used to evaluate performance of the association built. Finally, we built an animal model for myocardial ischemia and validated the model by established diagnosis criterion of myocardial ischemia. Furthermore, the built association was used to evaluate whether an animal is with BSS. The results indicated that the strategy successfully evaluates and separates the animal model for syndrome in TCM from the counterpart for myocardial ischemia. The novel strategy presented in the paper provides a better insight to understand the nature of syndrome in TCM and pave a basis for personalized therapies of UA.
KeywordUnstable Angina Blood Stasis Syndrome Traditional Chinese Medicine Data Mining Animal Model Myocardial Ischemia Classification Radial Basis Function Network
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordALGORITHM ; FAILURE ; DISEASE
Indexed BySCI
Language英语
WOS Research AreaLife Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
WOS SubjectBiology ; Mathematical & Computational Biology
WOS IDWOS:000273426400001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4142
Collection综合信息系统研究中心
Affiliation1.Beijing Univ Chinese Med, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Guo, Shuzhen,Chen, Jianxin,Zhao, Huihui,et al. BUILDING AND EVALUATING AN ANIMAL MODEL FOR SYNDROME IN TRADITIONAL CHINESE MEDICINE IN THE CONTEXT OF UNSTABLE ANGINA (MYOCARDIAL ISCHEMIA) BY SUPERVISED DATA MINING APPROACHES[J]. JOURNAL OF BIOLOGICAL SYSTEMS,2009,17(4):531-546.
APA Guo, Shuzhen.,Chen, Jianxin.,Zhao, Huihui.,Wang, Wei.,Yi, Jianqiang.,...&Wang, Yong.(2009).BUILDING AND EVALUATING AN ANIMAL MODEL FOR SYNDROME IN TRADITIONAL CHINESE MEDICINE IN THE CONTEXT OF UNSTABLE ANGINA (MYOCARDIAL ISCHEMIA) BY SUPERVISED DATA MINING APPROACHES.JOURNAL OF BIOLOGICAL SYSTEMS,17(4),531-546.
MLA Guo, Shuzhen,et al."BUILDING AND EVALUATING AN ANIMAL MODEL FOR SYNDROME IN TRADITIONAL CHINESE MEDICINE IN THE CONTEXT OF UNSTABLE ANGINA (MYOCARDIAL ISCHEMIA) BY SUPERVISED DATA MINING APPROACHES".JOURNAL OF BIOLOGICAL SYSTEMS 17.4(2009):531-546.
Files in This Item: Download All
File Name/Size DocType Version Access License
2009 JBS - Building (494KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guo, Shuzhen]'s Articles
[Chen, Jianxin]'s Articles
[Zhao, Huihui]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guo, Shuzhen]'s Articles
[Chen, Jianxin]'s Articles
[Zhao, Huihui]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guo, Shuzhen]'s Articles
[Chen, Jianxin]'s Articles
[Zhao, Huihui]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 2009 JBS - Building and Evaluating an Animal Model for Syndrome in Traditional Chinese Medicine in the Context of Unstable Angina.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.