An innovative method for screening and evaluating the degree of diabetic retinopathy and drug treatment based on artificial intelligence algorithms

doi:10.1016/j.phrs.2020.104986

	An innovative method for screening and evaluating the degree of diabetic retinopathy and drug treatment based on artificial intelligence algorithms
	Xie, Qiwei 1; Liu, Yanfei 2,3; Huang, Hui 4; Hong, Bei 5; Wang, Jinxin 4; Han, Hua6,7 ; Liu, Yue 2
发表期刊	PHARMACOLOGICAL RESEARCH
ISSN	1043-6618
	2020-09-01
卷号	159 页码:9
通讯作者	Han, Hua(hua.han@ia.ac.cn) ; Liu, Yue(liuyueheart@hotmail.com)
摘要	Current methods of evaluating the degree of diabetic retinopathy are highly subjective and have no quantitative standard. To objectively evaluate the slight changes in tissue structure during the early stage of retinal diseases, a subjective interpretation and qualitative analysis of the pathological sections of retinal HE in diabetic animals is required for screening and evaluating the degree of diabetic retinopathy and drug efficacy. To develop an innovative method for screening and evaluating the degree of diabetic retinopathy and drug treatment based on artificial intelligence algorithms. Based on the change law of the early nerve fiber layer and the ganglion cells, we get disparate characteristics of the microscopic image of diabetes animal retina HE slices. Using image recognition and deep learning methods on these HE slices, we can identify the changes in the ganglion cells and nerve fiber layer for diagnosing early retinopathy and evaluated the therapeutic effect of the potential drugs. We conduct quantitative calculation per unit length of the nerve fiber layer and total area of the nerve fiber layer to identify biology significance of edema. Additionally, we also perform quantitative calculation with the number of unit area ganglion cells to identify the section in biology cell hyperplasia. Finally, we get the significance of quantitative calculation on the unit cell area to identify ganglion cell shriveling in biology. In addition to the evaluation of the disease degree and changes, we also obtained retinal HE sections after different drug interventions and evaluated the therapeutic effect of the drugs. This study presents a novel quantitative method for screening and evaluating of diabetic retinopathy and drug efficacy.
关键词	Diabetic retinopathy Artificial intelligence Method Hematoxylin-eosin Chinese medicine
DOI	10.1016/j.phrs.2020.104986
关键词[WOS]	NERVE-FIBER LAYER ; DISEASE
收录类别	SCI
语种	英语
资助项目	Special Project for Outstanding Young Talents of China Academy of Chinese Medical Sciences[ZZ13-YQ-001] ; Beijing NOVA Program[Z171100001117027] ; National Natural Science Foundation of China[61673381] ; Special Program of Beijing Municipal Science & Technology Commission[Z181100003818001] ; Special Program of Beijing Municipal Science & Technology Commission[Z181100000118002] ; Strategic Priority Research Program, CAS[XDB32030200] ; Bureau of International Cooperation, CAS[153D31KYSB20170059]
项目资助者	Special Project for Outstanding Young Talents of China Academy of Chinese Medical Sciences ; Beijing NOVA Program ; National Natural Science Foundation of China ; Special Program of Beijing Municipal Science & Technology Commission ; Strategic Priority Research Program, CAS ; Bureau of International Cooperation, CAS
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
WOS记录号	WOS:000566435200004
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
七大方向——子方向分类	人工智能+医疗
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/41537
专题	脑图谱与类脑智能实验室_微观重建与智能分析
通讯作者	Han, Hua; Liu, Yue
作者单位	1.Beijing Univ Technol, Res Base Beijing Modern Mfg Dev, Beijing 100124, Peoples R China 2.China Acad Chinese Med Sci, Cardiovasc Dis Ctr, Xiyuan Hosp, Beijing 100091, Peoples R China 3.Beijing Univ Chinese Med, Grad Sch, Beijing 100029, Peoples R China 4.Beijing Duan Dian Pharmaceut Res & Dev Co Ltd, Beijing, Peoples R China 5.Chinese Acad Sci, Res Ctr Brain Inspired Intelligence, Inst Automat, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 7.Univ Chinese Acad Sci, Sch Future Technol, Beijing, Peoples R China
通讯作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Xie, Qiwei,Liu, Yanfei,Huang, Hui,et al. An innovative method for screening and evaluating the degree of diabetic retinopathy and drug treatment based on artificial intelligence algorithms[J]. PHARMACOLOGICAL RESEARCH,2020,159:9.
APA	Xie, Qiwei.,Liu, Yanfei.,Huang, Hui.,Hong, Bei.,Wang, Jinxin.,...&Liu, Yue.(2020).An innovative method for screening and evaluating the degree of diabetic retinopathy and drug treatment based on artificial intelligence algorithms.PHARMACOLOGICAL RESEARCH,159,9.
MLA	Xie, Qiwei,et al."An innovative method for screening and evaluating the degree of diabetic retinopathy and drug treatment based on artificial intelligence algorithms".PHARMACOLOGICAL RESEARCH 159(2020):9.