CASIA OpenIR  > 中国科学院分子影像重点实验室
Linear scheme for the direct reconstruction of noncontact time-domain fluorescence molecular lifetime tomography
Zhang, Peng1,2; Liu, Jie1; Hui, Hui2,3,4; An, Yu5; Wang, Kun2,3,4; Yang, Xin2,3,4; Tian, Jie2,3,4
Source PublicationAPPLIED OPTICS
ISSN1559-128X
2020-09-10
Volume59Issue:26Pages:7961-7967
Corresponding AuthorLiu, Jie()
AbstractDirect reconstruction of the noncontact time-domain fluorescence molecular lifetime tomography (TD-FMLT) with current nonlinear algorithms has suffered from complexity and heavy computation loads of the physical model for a large imaging area in TD-FMLT. In this work, we discretize the system matrix along time points and apply a linearized reconstruction algorithm using the fused least absolute shrinkage and selection operator method. The reconstructed yield map and object geometry are used as a priori information to mitigate the ill conditions. This approach is implemented on a fully noncontact TD-FMLT system equipped with a femtosecond pulse laser and a high-speed, time-gated camera. We validate the methodology using both numerical simulations and inhomogeneous phantom experiments. The results exhibit good localization accuracy for fluorescent targets and an efficient computation capability for the reconstruction of fluorescence lifetime in noncontact TD-FMLT. We envision that the proposed linear scheme for the direct reconstruction method in noncontact TD-FMLT has a significant potential for in vivo preclinical studies. (C) 2020 Optical Society of America
DOI10.1364/AO.398967
WOS KeywordSYSTEM
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFA0700401] ; National Key Research and Development Program of China[2016YFC0103803] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671851] ; National Natural Science Foundation of China[81827808] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81571836] ; National Natural Science Foundation of China[81227901] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDB32030200] ; Scientific Instrument R&D Program of Chinese Academy of Sciences[YJKYYQ20170075] ; Youth Innovation Promotion Association of the ChineseAcademy of Sciences[2018167]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Scientific Instrument R&D Program of Chinese Academy of Sciences ; Youth Innovation Promotion Association of the ChineseAcademy of Sciences
WOS Research AreaOptics
WOS SubjectOptics
WOS IDWOS:000571484700029
PublisherOPTICAL SOC AMER
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/42014
Collection中国科学院分子影像重点实验室
Corresponding AuthorLiu, Jie
Affiliation1.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Dept Biomed Engn, Beijing 100044, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Inst Automat, Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100083, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Peng,Liu, Jie,Hui, Hui,et al. Linear scheme for the direct reconstruction of noncontact time-domain fluorescence molecular lifetime tomography[J]. APPLIED OPTICS,2020,59(26):7961-7967.
APA Zhang, Peng.,Liu, Jie.,Hui, Hui.,An, Yu.,Wang, Kun.,...&Tian, Jie.(2020).Linear scheme for the direct reconstruction of noncontact time-domain fluorescence molecular lifetime tomography.APPLIED OPTICS,59(26),7961-7967.
MLA Zhang, Peng,et al."Linear scheme for the direct reconstruction of noncontact time-domain fluorescence molecular lifetime tomography".APPLIED OPTICS 59.26(2020):7961-7967.
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