A preliminary study of dual-band confocal laser endomicroscopy combined with image mosaic in the diagnosis of liver cancer

doi:10.1016/j.nano.2020.102250

	A preliminary study of dual-band confocal laser endomicroscopy combined with image mosaic in the diagnosis of liver cancer
	Zheng, Sheng 1,2,3,4; Zhang, Ying 2,5; Chen, Shujie 2,5; Zhang, Zeyu3,4 ; Chen, Fei 1,2; Zhang, Zizhen 1,2; Hu, Zhenhua3,4 ; Tian, Jie 3,4; Wang, Liangjing 1,2
发表期刊	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
ISSN	1549-9634
	2020-10-01
卷号	29 页码:9
通讯作者	Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Wang, Liangjing(wangljzju@zju.edu.cn)
摘要	Accurate identification of tumor tissues and their margins are still challenging for conventional clinical imaging methods during liver cancer surgery. In this study, dual-band confocal laser endomicroscopy (CLE) combined with image mosaic was used to guide liver cancer surgery. In the experiments with mice bearing orthotropic liver tumor, CLE can accurately detect the tumors and identify their margins with two excitation wavelengths of 488 nm and 660 nm by clinically available dyes fluorescein sodium (FS) or indocyanine green (ICG). The mosaic CLE images enlarged the imaging field and detected the liver tumor margins more accurately. Normal liver tissues fluorescence intensity of CLE images was significantly higher than that of tumor tissues in the same tumor-bearing mice (P < 0.0001). Overall, dual-band CLE imaging demonstrates to be a promising method to identify liver tumor tissues and margins, which has the prospect of clinical application and helps to achieve intraoperative radical resection. (C) 2020 Elsevier Inc. All rights reserved.
关键词	Confocal laser endomicroscopy Primary liver cancer Fluorescein sodium Indocyanine green Tumor margin Image mosaic
DOI	10.1016/j.nano.2020.102250
关键词[WOS]	FLUORESCENCE ; SURGERY ; MANAGEMENT ; BIOPSY
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0102600] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[81671759] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; Beijing Natural Science Foundation[JQ19027] ; Beijing Nova Program[Z181100006218046] ; innovative research team of high-level local universities in Shanghai ; Zhuhai High-level Health Personnel Team Project[Zhuhai HLHPTP201703]
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Scientific Instrument Developing Project of the Chinese Academy of Sciences ; Beijing Natural Science Foundation ; Beijing Nova Program ; innovative research team of high-level local universities in Shanghai ; Zhuhai High-level Health Personnel Team Project
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
WOS类目	Nanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS记录号	WOS:000573096200001
出版者	ELSEVIER
七大方向——子方向分类	医学影像处理与分析
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/42042
专题	中国科学院分子影像重点实验室
通讯作者	Hu, Zhenhua; Tian, Jie; Wang, Liangjing
作者单位	1.Zhejiang Univ, Dept Gastroenterol, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Peoples R China 2.Zhejiang Univ, Inst Gastroenterol, Hangzhou, Peoples R China 3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging,State Key Lab Managem, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Zhejiang Univ, Sir Run Shaw Hosp, Dept Gastroenterol, Hangzhou, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Zheng, Sheng,Zhang, Ying,Chen, Shujie,et al. A preliminary study of dual-band confocal laser endomicroscopy combined with image mosaic in the diagnosis of liver cancer[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2020,29:9.
APA	Zheng, Sheng.,Zhang, Ying.,Chen, Shujie.,Zhang, Zeyu.,Chen, Fei.,...&Wang, Liangjing.(2020).A preliminary study of dual-band confocal laser endomicroscopy combined with image mosaic in the diagnosis of liver cancer.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,29,9.
MLA	Zheng, Sheng,et al."A preliminary study of dual-band confocal laser endomicroscopy combined with image mosaic in the diagnosis of liver cancer".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 29(2020):9.