CASIA OpenIR  > 中国科学院分子影像重点实验室
A preliminary study of dual-band confocal laser endomicroscopy combined with image mosaic in the diagnosis of liver cancer
Zheng, Sheng1,2,3,4; Zhang, Ying2,5; Chen, Shujie2,5; Zhang, Zeyu3,4; Chen, Fei1,2; Zhang, Zizhen1,2; Hu, Zhenhua3,4; Tian, Jie3,4; Wang, Liangjing1,2
Source PublicationNANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
ISSN1549-9634
2020-10-01
Volume29Pages:9
Corresponding AuthorHu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Wang, Liangjing(wangljzju@zju.edu.cn)
AbstractAccurate identification of tumor tissues and their margins are still challenging for conventional clinical imaging methods during liver cancer surgery. In this study, dual-band confocal laser endomicroscopy (CLE) combined with image mosaic was used to guide liver cancer surgery. In the experiments with mice bearing orthotropic liver tumor, CLE can accurately detect the tumors and identify their margins with two excitation wavelengths of 488 nm and 660 nm by clinically available dyes fluorescein sodium (FS) or indocyanine green (ICG). The mosaic CLE images enlarged the imaging field and detected the liver tumor margins more accurately. Normal liver tissues fluorescence intensity of CLE images was significantly higher than that of tumor tissues in the same tumor-bearing mice (P < 0.0001). Overall, dual-band CLE imaging demonstrates to be a promising method to identify liver tumor tissues and margins, which has the prospect of clinical application and helps to achieve intraoperative radical resection. (C) 2020 Elsevier Inc. All rights reserved.
KeywordConfocal laser endomicroscopy Primary liver cancer Fluorescein sodium Indocyanine green Tumor margin Image mosaic
DOI10.1016/j.nano.2020.102250
WOS KeywordFLUORESCENCE ; SURGERY ; MANAGEMENT ; BIOPSY
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0102600] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[81671759] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; Beijing Natural Science Foundation[JQ19027] ; Beijing Nova Program[Z181100006218046] ; innovative research team of high-level local universities in Shanghai ; Zhuhai High-level Health Personnel Team Project[Zhuhai HLHPTP201703]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Scientific Instrument Developing Project of the Chinese Academy of Sciences ; Beijing Natural Science Foundation ; Beijing Nova Program ; innovative research team of high-level local universities in Shanghai ; Zhuhai High-level Health Personnel Team Project
WOS Research AreaScience & Technology - Other Topics ; Research & Experimental Medicine
WOS SubjectNanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS IDWOS:000573096200001
PublisherELSEVIER
Sub direction classification医学影像处理与分析
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/42042
Collection中国科学院分子影像重点实验室
Corresponding AuthorHu, Zhenhua; Tian, Jie; Wang, Liangjing
Affiliation1.Zhejiang Univ, Dept Gastroenterol, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Peoples R China
2.Zhejiang Univ, Inst Gastroenterol, Hangzhou, Peoples R China
3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging,State Key Lab Managem, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Zhejiang Univ, Sir Run Shaw Hosp, Dept Gastroenterol, Hangzhou, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zheng, Sheng,Zhang, Ying,Chen, Shujie,et al. A preliminary study of dual-band confocal laser endomicroscopy combined with image mosaic in the diagnosis of liver cancer[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2020,29:9.
APA Zheng, Sheng.,Zhang, Ying.,Chen, Shujie.,Zhang, Zeyu.,Chen, Fei.,...&Wang, Liangjing.(2020).A preliminary study of dual-band confocal laser endomicroscopy combined with image mosaic in the diagnosis of liver cancer.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,29,9.
MLA Zheng, Sheng,et al."A preliminary study of dual-band confocal laser endomicroscopy combined with image mosaic in the diagnosis of liver cancer".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 29(2020):9.
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