A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence

doi:10.1021/acsnano.0c01453

	A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence
	Zhou, Tianjun 1,2,3; Liang, Xiaolong 4; Wang, Peifeng 1,2,3; Hu, Yueyang 1,2,3; Qi, Yafei 2; Jin, Yushen5 ; Du, Yang2,6 ; Fang, Chihua 1; Tian, Jie 2,7
发表期刊	ACS NANO
ISSN	1936-0851
	2020-10-27
卷号	14 期号:10 页码:12679-12696
通讯作者	Du, Yang(yang.du@ia.ac.cn) ; Fang, Chihua(fangch_dr@163.com) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要	Hepatocellular carcinoma (HCC) is a common and highly malignant tumor that is prone to recurrence and metastasis and has no effective treatment. Unsurprisingly, its prognosis is quite poor; early detection methods and effective low toxicity treatments are urgently needed. To achieve these goals, we designed a multifunctional, U.S. Food and Drug Administration-approved Prussian blue (PB) nanoparticle (NP) with a porous metal organic frame loaded with sorafenib l (SF), conjugated with HCC-specific targeting peptide SP94 and the near-infrared dye cyanine (Cy)S.S. These NPs are amenable to multimodal imaging for dynamic monitoring of their biodistribution and tumor-targeting effects. The SP94-PB-SF-Cy5.5 NPs achieved targeted delivery and controlled SF release and exhibited good photothermal effects. In this strategy, photothermal therapy and SF treatment complement each other, reducing the side effects of SF and achieving a therapeutic effect without local tumor recurrence. In addition, the catalase-like ability of l the NPs alleviates tumor hypoxia, and their photothermal effects l induce immunogenic cell death, leading to the release of tumor-associated antigens. These effects combine to trigger an antitumor immune response; the NPs also displayed promising inhibitory effects on tumor metastasis and recurrence and produced an abscopal effect and long-term immunological memory when combined with antiprogrammed death-ligand I (PD-LI) immunotherapy. These safe, multifunctional NPs represent a valuable treatment option for HCC. In addition, this next-generation treatment model may provide some ideas for the management of HCC and other cancers.
关键词	hepatocellular carcinoma prussian blue photothermal therapy sorafenib hypoxia antiprogrammed death-ligand I immunotherapy
DOI	10.1021/acsnano.0c01453
关键词[WOS]	PRUSSIAN BLUE NANOPARTICLES ; CHECKPOINT BLOCKADE ; T-CELLS ; CANCER ; GENERATION ; IMMUNITY ; THERAPY ; SIGNALS
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81627805] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81822022] ; National Natural Science Foundation of China[81771846] ; National Key Research and Development Program of China[2 0 1 7YFAO 2 0 5 2 0 0] ; National Key Research and Development Program of China[2017YFA0700401] ; National Key Research and Development Program of China[2016YFA0100902] ; National Key Research and Development Program of China[2016YFC0106500] ; Science and Technology Plan Project of Guangzhou[201604020144] ; Science and Technology Plan Project of Guangzhou[201704020141] ; NSFC-GD Union Foundation[U1401254] ; Beijing Excellent Young Talents Training Support Program[2018000021223ZK48] ; Peking University Third Hospital[BYSYZD2019018] ; Peking University Third Hospital[jyzc2018-02] ; Peking University Third Hospital[BYSY2015023]
项目资助者	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Science and Technology Plan Project of Guangzhou ; NSFC-GD Union Foundation ; Beijing Excellent Young Talents Training Support Program ; Peking University Third Hospital
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000586793400026
出版者	AMER CHEMICAL SOC
七大方向——子方向分类	其他
引用统计	被引频次：108[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/42678
专题	中国科学院分子影像重点实验室
通讯作者	Du, Yang; Fang, Chihua; Tian, Jie
作者单位	1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 3.Prov Clin & Engn Ctr Digital Med, Guangzhou 510280, Peoples R China 4.Peking Univ Third Hosp, Dept Ultrasound, Beijing 100191, Peoples R China 5.Beijing Ctr Dis Control & Prevent, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Zhou, Tianjun,Liang, Xiaolong,Wang, Peifeng,et al. A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence[J]. ACS NANO,2020,14(10):12679-12696.
APA	Zhou, Tianjun.,Liang, Xiaolong.,Wang, Peifeng.,Hu, Yueyang.,Qi, Yafei.,...&Tian, Jie.(2020).A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence.ACS NANO,14(10),12679-12696.
MLA	Zhou, Tianjun,et al."A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence".ACS NANO 14.10(2020):12679-12696.