Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats

doi:10.3389/fnins.2020.586321

	Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats
	Wang, Wenzhu 1,2; Liu, Xu3 ; Yang, Zhengyi4 ; Shen, Hui 5; Liu, Lixu 3,6; Yu, Yan 1,2,7; Zhang, Tong 1,2,4
发表期刊	FRONTIERS IN NEUROSCIENCE
	2020-11-30
卷号	14 页码:16
通讯作者	Wang, Wenzhu(wzhwang11@163.com)
摘要	The cognitive impairment caused by cerebral ischemia/reperfusion is an unsolved problem in the field of international neural rehabilitation. Not only ameliorates the consciousness level of certain patients who suffered from ischemia-reperfusion injury and were comatose for a long time period after cerebral resuscitation treatment, but levodopa also improves the symptoms of neurological deficits in rats with global cerebral ischemia-reperfusion injury. However, Levodopa has not been widely used as a brain protection drug after cardiopulmonary resuscitation, because of its unclear repair mechanism. Levodopa was used to study the neuroplasticity in the hippocampus of global cerebral ischemia/reperfusion injury rat model, established by Pulsinelli's four-vessel occlusion method. Levodopa was injected intraperitoneally at 50 mg/kg/d for 7 consecutive days after 1st day of surgery. The modified neurological function score, Morris water maze, magnetic resonance imaging, Nissl and TH staining, electron microscopy and western blot were used in the present study. The results showed that levodopa improved the neurological function and learning and memory of rats after global cerebral ischemia/reperfusion injury, improved the integrity of white matter, and density of gray matter in the hippocampus, increased the number of synapses, reduced the delayed neuronal death, and increased the expression of synaptic plasticity-related proteins (BDNF, TrkB, PSD95, and Drebrin) in the hippocampus. In conclusion, levodopa can improve cognitive function after global cerebral ischemia/reperfusion injury by enhancing the synaptic plasticity in the hippocampus.
关键词	levodopa hippocampus global cerebral ischemia reperfusion injury structural synaptic plasticity cognitive function
DOI	10.3389/fnins.2020.586321
关键词[WOS]	HOSPITAL CARDIAC-ARREST ; DENDRITIC SPINE LOSS ; MOTOR RECOVERY ; HEART-DISEASE ; DOPAMINE ; STROKE ; MEMORY ; MATTER ; REPERFUSION ; DORSAL
收录类别	SCI
语种	英语
资助项目	Special Fund for the Fundamental Research Funds for Central Public Welfare Research Institutes[2018CZ-5] ; Special Fund for the Fundamental Research Funds for Central Public Welfare Research Institutes[2019CZ-7]
项目资助者	Special Fund for the Fundamental Research Funds for Central Public Welfare Research Institutes
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000598158900001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/42711
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Wang, Wenzhu
作者单位	1.China Rehabil Sci Inst, Chinese Inst Rehabil Sci, Beijing, Peoples R China 2.China Rehabil Res Ctr, Beijing Key Lab Neural Injury & Rehabil, Beijing, Peoples R China 3.Capital Med Univ, Sch Rehabil Med, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 5.Tianjin Med Univ, Sch Biomed Engn, Tianjin, Peoples R China 6.Beijing Boai Hosp, China Rehabil Res Ctr, Beijing, Peoples R China 7.Beijing Inst Brain Disorders, Ctr Neural Injury & Repair, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wenzhu,Liu, Xu,Yang, Zhengyi,et al. Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats[J]. FRONTIERS IN NEUROSCIENCE,2020,14:16.
APA	Wang, Wenzhu.,Liu, Xu.,Yang, Zhengyi.,Shen, Hui.,Liu, Lixu.,...&Zhang, Tong.(2020).Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats.FRONTIERS IN NEUROSCIENCE,14,16.
MLA	Wang, Wenzhu,et al."Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats".FRONTIERS IN NEUROSCIENCE 14(2020):16.