Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer | |
Guo, Pengyu1,2,3; Wang, Lu1,2; Shang, Wenting3; Chen, Jiuwei1,2; Chen, Ziyin1,2; Xiong, Feng1,2; Wang, Ziqi1,2; Tong, Zhichao1,2; Wang, Keliang1,2; Yang, Liming4; Tian, Jie3; Xu, Wanhai1,2 | |
发表期刊 | ACS APPLIED MATERIALS & INTERFACES |
ISSN | 1944-8244 |
2020-12-09 | |
卷号 | 12期号:49页码:54367-54377 |
通讯作者 | Tian, Jie(jie.tian@ia.ac.cn) ; Xu, Wanhai(xuwanhai@163.com) |
摘要 | Bladder cancer displays multiple biological features aided in drug resistance; therefore, single therapy fails to induce complete tumor regression. To address this issue, various kinds of cell death of cancer cells as well as restoring tumor immune microenvironment need to be taken into consideration. Here, we introduce a gel system termed AuNRs&IONs@Gel, which target-delivers a combination of photothermal, ferroptotic, and immune therapy through intravesical instillation. AuNRs&IONs@Gel consists of a gel delivery platform, embedded gold nanorods (AuNRs), and iron oxide nanoparticles (IONs). The targeted delivery gel platform provides dextran aldehyde-selective adhesion with cancer collagen. In this condition, photothermal therapy can be performed by gold nanorods (AuNRs) under imaging-guided near-infrared radiation. Local high concentrations of IONs can be absorbed by cancer cell to induce ferroptosis. Moreover, tumor-associated macrophages which often display an immune-suppressive M2-like phenotype will be repolarized by IONs into the antitumor M1-like phenotype, exerting a direct antitumor effect and professional antigen presentation of dead cancer cells. This process triggers a potent immune response of innate and adapt immunities to protect tumor rechallenge in long terms. Our triple therapy strategy employs FDA-approved nanoparticles to inhibit bladder cancer which may possess great potential for clinical translation. |
关键词 | bladder cancer ferroptosis macrophage intravesical therapy PTT |
DOI | 10.1021/acsami.0c15176 |
关键词[WOS] | NANOMEDICINE |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[81771898] ; National Natural Science Foundation of China[51903069] ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University[HYDSYYXQN202001] ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University[HY-DSYYXQN202003] ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University[HYDSYYXQN202004] ; Fundamental Research Funds for the Provincial Universities[2019-KYYWF-0372] ; China Postdoctoral Science Foundation[2020M680047] ; Special project of Heilongjiang Postdoctoral Fund[LBH-TZ1017] ; Applied Technology Research and Development Project of Heilongjiang Province[GY2019YF0086] |
项目资助者 | National Natural Science Foundation of China ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University ; Fundamental Research Funds for the Provincial Universities ; China Postdoctoral Science Foundation ; Special project of Heilongjiang Postdoctoral Fund ; Applied Technology Research and Development Project of Heilongjiang Province |
WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
WOS记录号 | WOS:000599505200009 |
出版者 | AMER CHEMICAL SOC |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/42735 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Tian, Jie; Xu, Wanhai |
作者单位 | 1.Harbin Med Univ, Hosp 4, Urol Surg Dept, Heilongjiang Key Lab Sci Res Urol, Harbin 150081, Peoples R China 2.Harbin Med Univ, Hosp 4, NHC Key Lab Mol Probes & Targeted Diag & Therapy, Harbin 150081, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Inst Automat, Beijing 100190, Peoples R China 4.Harbin Med Univ, Dept Pathophysiol, Key Lab Cardiovasc Pathophysiol, Harbin 150081, Peoples R China |
推荐引用方式 GB/T 7714 | Guo, Pengyu,Wang, Lu,Shang, Wenting,et al. Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(49):54367-54377. |
APA | Guo, Pengyu.,Wang, Lu.,Shang, Wenting.,Chen, Jiuwei.,Chen, Ziyin.,...&Xu, Wanhai.(2020).Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer.ACS APPLIED MATERIALS & INTERFACES,12(49),54367-54377. |
MLA | Guo, Pengyu,et al."Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer".ACS APPLIED MATERIALS & INTERFACES 12.49(2020):54367-54377. |
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