CASIA OpenIR  > 中国科学院分子影像重点实验室
Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer
Guo, Pengyu1,2,3; Wang, Lu1,2; Shang, Wenting3; Chen, Jiuwei1,2; Chen, Ziyin1,2; Xiong, Feng1,2; Wang, Ziqi1,2; Tong, Zhichao1,2; Wang, Keliang1,2; Yang, Liming4; Tian, Jie3; Xu, Wanhai1,2
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
2020-12-09
Volume12Issue:49Pages:54367-54377
Corresponding AuthorTian, Jie(jie.tian@ia.ac.cn) ; Xu, Wanhai(xuwanhai@163.com)
AbstractBladder cancer displays multiple biological features aided in drug resistance; therefore, single therapy fails to induce complete tumor regression. To address this issue, various kinds of cell death of cancer cells as well as restoring tumor immune microenvironment need to be taken into consideration. Here, we introduce a gel system termed AuNRs&IONs@Gel, which target-delivers a combination of photothermal, ferroptotic, and immune therapy through intravesical instillation. AuNRs&IONs@Gel consists of a gel delivery platform, embedded gold nanorods (AuNRs), and iron oxide nanoparticles (IONs). The targeted delivery gel platform provides dextran aldehyde-selective adhesion with cancer collagen. In this condition, photothermal therapy can be performed by gold nanorods (AuNRs) under imaging-guided near-infrared radiation. Local high concentrations of IONs can be absorbed by cancer cell to induce ferroptosis. Moreover, tumor-associated macrophages which often display an immune-suppressive M2-like phenotype will be repolarized by IONs into the antitumor M1-like phenotype, exerting a direct antitumor effect and professional antigen presentation of dead cancer cells. This process triggers a potent immune response of innate and adapt immunities to protect tumor rechallenge in long terms. Our triple therapy strategy employs FDA-approved nanoparticles to inhibit bladder cancer which may possess great potential for clinical translation.
Keywordbladder cancer ferroptosis macrophage intravesical therapy PTT
DOI10.1021/acsami.0c15176
WOS KeywordNANOMEDICINE
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81771898] ; National Natural Science Foundation of China[51903069] ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University[HYDSYYXQN202001] ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University[HY-DSYYXQN202003] ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University[HYDSYYXQN202004] ; Fundamental Research Funds for the Provincial Universities[2019-KYYWF-0372] ; China Postdoctoral Science Foundation[2020M680047] ; Special project of Heilongjiang Postdoctoral Fund[LBH-TZ1017] ; Applied Technology Research and Development Project of Heilongjiang Province[GY2019YF0086]
Funding OrganizationNational Natural Science Foundation of China ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University ; Fundamental Research Funds for the Provincial Universities ; China Postdoctoral Science Foundation ; Special project of Heilongjiang Postdoctoral Fund ; Applied Technology Research and Development Project of Heilongjiang Province
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000599505200009
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/42735
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie; Xu, Wanhai
Affiliation1.Harbin Med Univ, Hosp 4, Urol Surg Dept, Heilongjiang Key Lab Sci Res Urol, Harbin 150081, Peoples R China
2.Harbin Med Univ, Hosp 4, NHC Key Lab Mol Probes & Targeted Diag & Therapy, Harbin 150081, Peoples R China
3.Chinese Acad Sci, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Inst Automat, Beijing 100190, Peoples R China
4.Harbin Med Univ, Dept Pathophysiol, Key Lab Cardiovasc Pathophysiol, Harbin 150081, Peoples R China
Recommended Citation
GB/T 7714
Guo, Pengyu,Wang, Lu,Shang, Wenting,et al. Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(49):54367-54377.
APA Guo, Pengyu.,Wang, Lu.,Shang, Wenting.,Chen, Jiuwei.,Chen, Ziyin.,...&Xu, Wanhai.(2020).Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer.ACS APPLIED MATERIALS & INTERFACES,12(49),54367-54377.
MLA Guo, Pengyu,et al."Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer".ACS APPLIED MATERIALS & INTERFACES 12.49(2020):54367-54377.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guo, Pengyu]'s Articles
[Wang, Lu]'s Articles
[Shang, Wenting]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guo, Pengyu]'s Articles
[Wang, Lu]'s Articles
[Shang, Wenting]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guo, Pengyu]'s Articles
[Wang, Lu]'s Articles
[Shang, Wenting]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.