A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma

doi:10.21037/atm-20-5341

	A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma
	Zhang, Weiqi 1,2; Hu, Zhenhua2,3 ; Tian, Jie 2,3,4,5; Fang, Chihua 1
发表期刊	ANNALS OF TRANSLATIONAL MEDICINE
ISSN	2305-5839
	2021
卷号	9 期号:2 页码:15
通讯作者	Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(tian@ieee.org) ; Fang, Chihua(fangch_dr@163.com)
摘要	Hepatectomy is a main therapeutic strategy for hepatocellular carcinoma (HCC), which requires removal of primary and disseminated tumors and maximum preservation of normal liver tissue. However, in a clinical operation, it is difficult to recognize the tumor tissue and its boundary with the naked eye and palpation, which often leads to insufficient or excessive resection. Near-infrared fluorescence (NIRF) imaging, a non-invasive, real-time, low-cost, and highly sensitive imaging technique has been extensively studied in surgical navigation. With the development of fluorescence imaging system and fluorescent probe, intraoperative tumor detection and margin definition can be achieved, making the operation more accurate. Advances in fluorescence imaging of HCC in the NIR region have focused on the traditional first NIR window (NIR-I, 700-900 nm), and have recently been extended to the second NIR window (NIR-II, 1,000- 1,700 nm). Compared with NIR-I imaging, fluorescence imaging in the NIR-II exhibits great advantages, including higher spatial resolution, deeper penetration depth, and lower optical absorption and scattering from biological substrates with minimal tissue autofluorescence. There is no doubt that developing novel NIRF probes for in vivo imaging of HCC has high significance and direct impact on the field of liver surgery. In this article, the development of various NIRF probes for fluorescence image guided HCC hepatectomy is reviewed, and current challenges and potential opportunities of these imaging probes are discussed.
关键词	Near-infrared fluorescence imaging (NIRF imaging) fluorescent probe hepatectomy hepatocellular carcinoma (HCC) NIR-I NIR-II
DOI	10.21037/atm-20-5341
关键词[WOS]	CLINICAL-PRACTICE GUIDELINES ; INDOCYANINE-GREEN ; IN-VIVO ; PHOTOACOUSTIC TOMOGRAPHY ; NAVIGATION SYSTEM ; GUIDED SURGERY ; LIVER-TUMORS ; MANAGEMENT ; RESECTION ; LIGHT
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2016YFC0106500] ; National Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[81627805] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[81671759] ; NSFC-GD Union Foundation, China[U1401254] ; National High Technology Research and Development Program of China (863 program)[2006AA02Z346] ; National High Technology Research and Development Program of China (863 program)[2012AA021105] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; Beijing Natural Science Foundation[JQ19027] ; Beijing Nova Program[Z181100006218046] ; innovative research team of high-level local universities in Shanghai
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; NSFC-GD Union Foundation, China ; National High Technology Research and Development Program of China (863 program) ; Scientific Instrument Developing Project of the Chinese Academy of Sciences ; Beijing Natural Science Foundation ; Beijing Nova Program ; innovative research team of high-level local universities in Shanghai
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS类目	Oncology ; Medicine, Research & Experimental
WOS记录号	WOS:000617883200023
出版者	AME PUBL CO
七大方向——子方向分类	医学影像处理与分析
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/43357
专题	中国科学院分子影像重点实验室
通讯作者	Hu, Zhenhua; Tian, Jie; Fang, Chihua
作者单位	1.Southern Med Univ, Guangdong Prov Clin & Engn Ctr Digital Med, Zhujiang Hosp, Dept Hepatobiliary Surg 1, Guangzhou, Peoples R China 2.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing Key Lab Mol Imaging, CAS Key Lab Mol Imaging,Inst Automat, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China 5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Zhang, Weiqi,Hu, Zhenhua,Tian, Jie,et al. A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma[J]. ANNALS OF TRANSLATIONAL MEDICINE,2021,9(2):15.
APA	Zhang, Weiqi,Hu, Zhenhua,Tian, Jie,&Fang, Chihua.(2021).A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma.ANNALS OF TRANSLATIONAL MEDICINE,9(2),15.
MLA	Zhang, Weiqi,et al."A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma".ANNALS OF TRANSLATIONAL MEDICINE 9.2(2021):15.