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Inhibition-directed multimodal imaging fusion patterns in adults with ADHD and its potential underlying "gene-brain-cognition" relationship
Guo, Xiaojie1,2,3; Liu, Lu1,2,3; Li, Tiantian4,5,6; Zhao, Qihua1,2,3; Li, Hui1,2,3; Huang, Fang1,2,3; Wang, Yanfei1,2,3; Qian, Qiujin1,2,3; Cao, Qingjiu1,2,3; Wang, Yufeng1,2,3; Calhoun, Vince D.7; Sui, Jing4,5,6,8; Sun, Li1,2,3
发表期刊CNS NEUROSCIENCE & THERAPEUTICS
ISSN1755-5930
2021-03-16
页码10
通讯作者Sui, Jing(kittysj@gmail.com) ; Sun, Li(sunlioh@bjmu.edu.cn)
摘要Aims: Inhibition deficits have been suggested to be a core cognitive impairment in attention-deficit/hyperactivity disorder (ADHD). Exploring imaging patterns and the potential genetic components associated with inhibition deficits would definitely promote our understanding of the neuropathological mechanism of ADHD. This study aims to investigate the multimodal imaging fusion features related to inhibition deficits in adults with ADHD (aADHD) and to make an exploratory analysis of the role of inhibition-related gene, NOS1, on those brain alterations. Methods: Specifically, multisite canonical correlation analysis with reference plus joint independent component analysis (MCCAR + jICA) was conducted to identify the joint co-varying gray matter volume (GMV) and the functional connectivity (FC) features related to inhibition in 69 aADHD and 44 healthy controls. Then, mediation analysis was employed to detect the relationship among inhibition-related imaging features, NOS1 ex1f-VNTR genotypes, and inhibition. Results: Inhibition-directed multimodal imaging fusion patterns of aADHD were reduced GMV and FC in inhibition network and increased GMV and FC in default mode network. The results showed a significant indirect effect of NOS1 ex1f-VNTR on inhibition via FC component [effect size = -0.54 (SE = 0.29), 95% CI = -1.16 to -0.01]. In addition, the results indicated a significant indirect effect of GMV on the inhibition via FC component [effect size = 0.43 (SE = 0.23), 95% CI = 0.12 to 1.00]. Conclusion: The findings suggested that reduced GMV and FC in inhibition network and increased GMV and FC in default mode network were jointly responsible for inhibition deficits in aADHD. Both the NOS1 ex1f-VNTR genotypes and GMV might influence the inhibition through the mediation effect of the aforementioned FC (NOS1/GMV(-> FC ->)Inhibition).
关键词adults with attention-deficit/hyperactivity disorder inhibition multimodal MRI fusion NOS1 ex1f-VNTR
DOI10.1111/cns.13625
收录类别SCI
语种英语
资助项目National Natural Sciences Foundation of China[81771479] ; National Natural Sciences Foundation of China[81971284] ; National Natural Sciences Foundation of China[81873802] ; National Natural Sciences Foundation of China[81471382] ; National Natural Sciences Foundation of China[61773380] ; Beijing Municipal Science and Technology Program[Z181100001518005] ; Beijing Municipal Science and Technology Program[Z171100001017089] ; Beijing Municipal Science and Technology Program[Z171100000117004] ; Beijing Natural Science Foundation[7172245] ; Sanming Project of Medicine in Shenzhen The ADHD research group from Peking University Sixth Hospital[SZSM201612036]
项目资助者National Natural Sciences Foundation of China ; Beijing Municipal Science and Technology Program ; Beijing Natural Science Foundation ; Sanming Project of Medicine in Shenzhen The ADHD research group from Peking University Sixth Hospital
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy
WOS类目Neurosciences ; Pharmacology & Pharmacy
WOS记录号WOS:000629303800001
出版者WILEY
七大方向——子方向分类医学影像处理与分析
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/44068
专题脑网络组研究
通讯作者Sui, Jing; Sun, Li
作者单位1.Peking Univ Sixth Hosp, Inst Mental Hlth, Beijing, Peoples R China
2.Peking Univ, Minist Hlth, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Emory Univ, Georgia Inst Technol, Georgia State Univ, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30322 USA
8.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing, Peoples R China
通讯作者单位中国科学院自动化研究所;  模式识别国家重点实验室
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GB/T 7714
Guo, Xiaojie,Liu, Lu,Li, Tiantian,et al. Inhibition-directed multimodal imaging fusion patterns in adults with ADHD and its potential underlying "gene-brain-cognition" relationship[J]. CNS NEUROSCIENCE & THERAPEUTICS,2021:10.
APA Guo, Xiaojie.,Liu, Lu.,Li, Tiantian.,Zhao, Qihua.,Li, Hui.,...&Sun, Li.(2021).Inhibition-directed multimodal imaging fusion patterns in adults with ADHD and its potential underlying "gene-brain-cognition" relationship.CNS NEUROSCIENCE & THERAPEUTICS,10.
MLA Guo, Xiaojie,et al."Inhibition-directed multimodal imaging fusion patterns in adults with ADHD and its potential underlying "gene-brain-cognition" relationship".CNS NEUROSCIENCE & THERAPEUTICS (2021):10.
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